Navigation Links
Time of day crucial to accurately test for diseases, new research finds
Date:7/10/2014

A new study published today in the journal PNAS (Proceedings of the National Academy of Sciences), has found that time of day and sleep deprivation have a significant effect on our metabolism. The finding could be crucial when looking at the best time of day to test for diseases such as cancer and heart disease, and for administering medicines effectively.

Researchers from the University of Surrey and The Institute of Cancer Research, London, investigated the links between sleep deprivation, body clock disruption and metabolism, and discovered a clear variation in metabolism according to the time of day.

Healthy male volunteers were put in an environment where light, sleep, meals and posture were controlled. Researchers collected blood samples every two hours to show how metabolic biomarkers change during the day. For the first 24 hours, the participants experienced a normal wake/sleep cycle. This was followed by 24 hours of wakefulness, to investigate the effect of sleep deprivation on metabolic rhythms. The results showed that metabolic processes are significantly increased during sleep deprivation. 27 metabolites, including serotonin, were found at higher levels in periods of sleep deprivation compared to levels during sleep.

Lead author Professor Debra Skene from the University of Surrey, said: "Our results show that if we want to develop a diagnostic test for a disease, it is imperative to take the time of day when taking blood samples into account, since this has a significant effect on metabolism. This is also key for administering medicines and determining when they will be at their most effective. Of course, this will have to be considered on a case-by-case basis, since many people such as shift workers will have a different sleep/wake cycle and timings will need to be adapted to their body clocks."

Co-Senior author, Dr Florence Raynaud, a group leader at The Institute of Cancer Research, London, said: "The study made accurate measurements of a large number of metabolites as they varied by time of day and under different sleep patterns. Our findings are likely to be important in interpreting the results of blood tests, and in understanding why some individuals respond differently to medication. They also set reference points for future studies looking at the connection between metabolic processes and diseases such as cancer."

The research was funded by a grant from the BBSRC awarded to a large team of researchers, and was conducted at the University of Surrey's Faculty of Health and Medical Sciences and at The Institute of Cancer Research, London.

Media enquiries: Peter La, Media Relations Office at the University of Surrey, Tel: 01483 689191 or E-mail: p.la@surrey.ac.uk

Notes to Editors:

About the University of Surrey

The University of Surrey is one of the UK's leading professional, scientific and technological universities with a world class research profile and a reputation for excellence in teaching and research. Ground-breaking research at the University is bringing direct benefit to all spheres of life helping industry to maintain its competitive edge and creating improvements in the areas of health, medicine, space science, the environment, communications, defence and social policy. Programmes in science and technology have gained widespread recognition and it also boasts flourishing programmes in dance and music, social sciences, management and languages and law. In addition to the campus on 150 hectares just outside Guildford, Surrey, the University also owns and runs the Surrey Research Park, which provides facilities for 110 companies employing 2,750 staff.


'/>"/>

Contact: Peter La
p.la@surrey.ac.uk
0044-148-368-9191
University of Surrey
Source:Eurekalert

Related biology technology :

1. Farm weeds have crucial role in sustainable agriculture
2. Botanical compound could prove crucial to healing influenza
3. Lucintel's Analysis of Global Catalysts Industry: Chemical and Automobile Industries Play Crucial Role in Growth
4. Study In Prenatal Diagnosis Finds Sequenom CMMs MaterniT21™ PLUS Lab-developed Test Accurately Detects Fetal Trisomies In Pregnant Women Carrying Twins Or Triplets
5. Blue Brain Project accurately predicts connections between neurons
6. Peer Reviewed Clinical Study Shows New Blood Test More Accurately Predicts Risk Of A Heart Attack
7. Wolters Kluwer Research Now Available via Bloomberg Tradebook
8. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
9. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
10. Researching graphene nanoelectronics for a post-silicon world
11. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Leading CEOs from biotech, pharmaceutical, ... and June 1st at The Four Seasons Hotel Boston. , The Boston CEO ... offering exclusive access to key decision makers who influence deal making and investment. ...
(Date:5/3/2016)... NY (PRWEB) , ... May 03, 2016 , ... ... NeuroTech NYC , the sensor and data driven conferences, will take place on June ... UnitedHealth's Vidya Raman-Tangella on incorporating technology -- including AR/VR, machine ...
(Date:5/3/2016)... New York, NY (PRWEB) , ... May 03, 2016 , ... ... Lenox Hill Hospital , for definitive prostate cancer treatment, patients traditionally had two main ... an appropriate treatment plan would be made. , New technology has enabled doctors ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... with its clients in mind, the fresh look and added functionality give the ... “Recent years have seen a dynamic shift in agriculture – from precision farming ...
Breaking Biology Technology:
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
(Date:3/10/2016)... 10, 2016   Unisys Corporation (NYSE: UIS ... (CBP) is testing its biometric identity solution at the ... to help identify certain non-U.S. citizens leaving the country. ... designed to help determine the efficiency and accuracy of using ... and will run until May 2016. --> ...
(Date:3/3/2016)... MONTEREY, Calif. , March 3, 2016  FlexTech, ... in the categories of Innovation, Research & Development, Leadership ... Industry Leadership. This is the 9 th year ... select group of companies and individuals from past ... nominations based on a pre-described set of criteria, by ...
Breaking Biology News(10 mins):