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Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting
Date:4/30/2009

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AFP464 is nearing completion of Phase I clinical testing at Jules Bordet Institute in Belgium, Institut Gustav Roussy in Paris, Mayo Clinic in Rochester, Minnesota, Karmanos Cancer Institute in Detroit and University of Maryland Marlene and Stewart Greenebaum Cancer Center in Baltimore. Tigris Pharmaceuticals expects to soon move to Phase II clinical studies, including studies in triple-negative breast cancer patients with the drug alone or in combination with vorinostat, depending on the molecular gene profile subtypes of the patients. Triple-negative breast cancer afflicts mostly young women under the age of 40 and is more prevalent in the African-American and Hispanic community. About 182,460 women in the United States were diagnosed with invasive breast cancer in 2008, approximately 15-18% of which are triple negative, and about 40,480 will die from the disease, according to the American Cancer Society.

"Patients with triple negative breast cancer do not benefit from endocrine therapy or molecularly targeted therapy such as trastuzumab because they lack the targets for these drugs," said Dr. Binh Nguyen, M.D., Ph.D., Chief Medical Officer of Tigris. "The potential of using molecular gene profile to target the appropriate patient population that most likely could benefit from the treatment with AFP-464 is the right direction in the clinical development of this difficult to treat disease."

About AFP-464

AFP-464, a Lysol prodrug of aminoflavone (AF), undergoes rapid conversion to AF by nonspecific plasma esterases. It has shown a unique pattern of growth inhibitory activity in the NCI's 60 tumor cell line screen, with breast, ovarian, lung and renal lines exhibiting particular sensitivity. The mechanism of action of AF is believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus,
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SOURCE Tigris Pharmaceuticals, Inc.
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