Navigation Links
Tigris Pharmaceuticals Files IND Application for GGTI-2418
Date:2/6/2009

BONITA SPRINGS, Fla., Feb. 6 /PRNewswire/ -- Tigris Pharmaceuticals, Inc., a privately held drug development company, announced today that it has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for GGTI-2418, a novel anticancer compound. GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways.

"The filing of this IND ahead of the scheduled date represents a major corporate achievement for the entire Tigris team," said Edmundo Muniz, M.D., Ph.D., President and Chief Executive Officer of Tigris. "Pending acceptance by the FDA, we plan to initiate a Phase 1 study of GGTI-2418 in two top Phase I cancer research centers in the first half of 2009. This will be the first geranylgeranyltransferase inhibitor in human clinical trials in this well-validated pathway and represents an important advancement in identifying novel approaches to treat cancer."

"The submission of this IND marks an extremely important and exciting time in the field of geranylgeranylation inhibitors. I look forward to the fruitful translation of our preclinical work to target patients whose tumors harbor aberrant signal transduction pathways most likely to respond to GGTI-2418," stated Said M. Sebti, Ph.D., Director of the Drug Discovery Program at the Moffitt Cancer Center and co-inventor of GGTI-2418. "This is a most important and gratifying step in the development of GGTI-2418 as a novel treatment for the devastating effects of cancer," noted Andrew Hamilton, Ph.D., Professor of Chemistry at Yale University and co-inventor of GGTI-2418.

Tigris in-licensed the exclusive worldwide rights to GGTI-2418 from Yale University and the University of South Florida.

About GGTI-2418

GGTI-2418 is
'/>"/>

SOURCE Tigris Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Corrected: XTL Biopharmaceuticals to Convene Extraordinary Shareholders Meetings after Receipt of Shareholder Letter
2. XTL Biopharmaceuticals to Convene Extraordinary Shareholders Meetings after Receipt of Shareholder Letter
3. Transcept Pharmaceuticals to Present at 11th Annual BIO CEO & Investor Conference
4. Peregrine Pharmaceuticals Bavituximab Achieves Primary Endpoint in First Stage of Phase II Lung Cancer Study
5. Poniard Pharmaceuticals to Present at the BIO CEO & Investor Conference
6. Amylin Pharmaceuticals Confirms Receipt of Director Nomination Notices
7. Endo Pharmaceuticals to Announce Fourth Quarter and 2008 Full-Year Financial Results on February 27, 2009
8. XTL Biopharmaceuticals Announces Receipt of NASDAQ Notice of Delisting
9. XTL Biopharmaceuticals Provides Update on Potential Strategic Alternatives
10. Indevus Pharmaceuticals Announces Release of 2008 Annual Report
11. Amylin Pharmaceuticals Appoints Vincent Mihalik Senior Vice President, Sales and Marketing and Chief Commercial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... August 29, 2014 Local veterinarian, Dr. ... Hospital are seeking candidates to participate in an investigational ... The ultimate goal of this study is to ... into one or two arthritically affected joints can help ... , Candidates for the current investigational study must be ...
(Date:8/29/2014)... 29, 2014 Intrinsic Imaging, an ... GAMP® 5 compliant imaging core lab, announced today ... II clinical trial to assess a new treatment ... trial, Intrinsic Imaging will provide comprehensive imaging core ... and charter development, site qualification, site training and ...
(Date:8/28/2014)... 2014 “This kit has an improved extraction ... 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin Product ... to plant owners and USDA-GIPSA inspection agencies that have a ... can take place in a matter of minutes with nothing ... test the feed and grain before accepting it, but they ...
(Date:8/28/2014)... PA (PRWEB) August 28, 2014 The ... create a culture that will allow individuals to perform ... becoming increasingly important for employers looking to compete in ... industries are embracing this trend, as the sector increasingly ... of a company, which will have real results on ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3
... Calif., Feb. 4 NeurogesX, Inc. (Nasdaq: ... commercializing novel pain management therapies, announced today that Anthony ... present at the 11th Annual BIO CEO & Investor ... 2009. Mr. DiTonno and Stephen Ghiglieri, Chief Financial Officer, ...
... Texcel,s custom medical device development and manufacturing ... the commercialization of their surgical, interventional, and implantable ... full array of services and technologies at the ... booth # 314.Texcel provides the manufacturing infrastructure and ...
... Art,s Way Manufacturing, Inc. (Nasdaq: ARTW ... Scientific, Inc. - Buildings For Science - has ... The new site, reflective of the company,s ... more user-friendly.Art,s Way Scientific ( http://www.buildingsforscience.com ) is ...
Cached Biology Technology:NeurogesX to Present at 11th Annual BIO CEO & Investor Conference 2NeurogesX to Present at 11th Annual BIO CEO & Investor Conference 3Texcel Highlights Medical Device Development & Manufacturing Solutions at MD&M West, booth 314 2Art's Way Manufacturing Announces Launch of New Web Site For Art's Way Scientific - Buildings For Science 2Art's Way Manufacturing Announces Launch of New Web Site For Art's Way Scientific - Buildings For Science 3
(Date:8/28/2014)... A unique method for delivering compounds that ... HIV and AIDS may be possible, thanks ... Agricultural Sciences., A semi-soft vaginal suppository made ... loaded with the antiviral drug Tenofovir provides ... against the spread of sexually transmitted infections ...
(Date:8/28/2014)... new roads will be built worldwide by 2050. Many ... where they bring an influx of destructive loggers, hunters ... has created a ,global roadmap, for prioritising road building ... demands of development and environmental protection. , The map ... natural importance of ecosystems and a ,road-benefits, layer that ...
(Date:8/28/2014)... more action is needed to ensure safeguards are in ... in PLOS ONE , researchers from Monash University, ... - combining results from different studies - to look ... areas, to determine whether they actually protect biodiversity. ... protecting an area from human exploitation made common sense, ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Protected areas proven to protect biodiversity 2
... 26 October 2008 Arpida (SWX: ARPN) today ... III clinical trials at the 48th Interscience Conference ... of America (IDSA) 46th annual meeting in Washington, ... antibiotic, showed high clinical cure rates which were ...
... 2008 -- The Soil Science Society of America (SSSA) recognized ... special Awards Ceremony during their Annual Meeting on Oct. 5-9 ... colleagues based on their professional achievements and meritorious service. Only ... be elected Fellow. The 2008 class of SSSA Fellows are: ...
... Berlin, Germany Current research suggests that stress may ... skin disease. The related report by Joachim et ... Cells towards Maturation and Migration: Key role of ICAM-1/LFA-1 ... American Journal of Pathology . Skin provides the ...
Cached Biology News:Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections 2Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections 3Soil Science Society of America presents 2008 fellows 2Soil Science Society of America presents 2008 fellows 3Soil Science Society of America presents 2008 fellows 4Soil Science Society of America presents 2008 fellows 5Stress may make you itch 2
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
D-biotin *50 mM aqueous solution* Secondary Detection Biotin–Avidin Detection Reagents Other...
Endothelin-converting enzyme 1 (EC 3.4.24.71) (ECE-1). [Source:Uniprot/SWISSPROT;Acc:P42892] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: