Navigation Links
ThromboGenics and BioInvent Announce Publication of Exciting Data on a Novel Class of Angiogenesis Inhibitors in Cell

LEUVEN, Belgium and LUND, Sweden, November 2 /PRNewswire/ --

- Novel Anti-PlGF Antibody, TB-403, Being Developed by ThromboGenics and BioInvent for Cancer Expected to Enter the Clinic Later This Year

ThromboGenics NV (Euronext Brussels: THR), a biotechnology company focused on vascular disease, and co-development partner, BioInvent International (Nordic Exchange: BINV), announce today the publication of data in Cell(1) that highlight for the first time the therapeutic potential of anti-PlGF agents to treat cancer based on research performed at the University of Leuven, Belgium and the Flanders Institute for Biotechnology (VIB). The data published in Cell show that antibodies against PlGF (placental growth factor) can inhibit cancer tumour growth and the development of metastases in preclinical models, without affecting healthy tissues. These attractive properties are due to PIGF inhibitors acting by blocking the formation of new blood vessels only in the cancer tissue.

ThromboGenics and BioInvent have made the decision to advance their lead anti-PIGF monoclonal antibody, TB-403, into the clinic, and expect to start the first Phase I clinical trial by the end of 2007.

In particular, preclinical data showed that anti-PlGF antibodies could:

- Inhibit tumour growth and the development occurrence of tumour metastases

- Inhibit tumour growth with a distinct but complementary mechanism to currently available anti-angiogenic therapy

- Not induce resistance because it does not evoke an "angiogenic rescue" by the tumour, in contrast to current angiogenesis inhibitors

- Enhance the sensitivity of tumours to anti-VEGF

- Amplify anti-tumour effect of chemotherapy

- Not cause or aggravate the typical side effects of anti-angiogenic antibodies when given as combination therapy.

Therefore, anti-PlGF antibodies, such as TB-403, potentially have an improved efficacy/toxicity profile that would be expected to inh

SOURCE ThromboGenics NV
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Speaker announces business members of IT Task Force
2. Doyle announces technology tax credits for Berbee
3. Doyle announces new energy, global warming policies
4. Doyle, WARF announce partnership to lure stem cell companies
5. Doyle announces $80M renewable energy strategy
6. GE announces first installation of Discovery VCT
7. UWM announces winners of RGI awards
8. Third Wave announces two senior management appointments
9. Mirus announces new method for making antibodies
10. Merge announces sofware updates, upcoming acquisition
11. Small Tree announces ethernet solution for Apple Xserv G5
Post Your Comments:
(Date:7/28/2014)... DUBLIN , July 28, 2014 Research ... "Global Particle Size Analysis Market 2014-2018" report to their ... Particle size analysis is a technique used to determine ... powder or liquid. It is crucial to analyze the size ... material. Therefore, particle size analysis is performed to determine the ...
(Date:7/25/2014)... live in each person,s digestive tract. Scientists believe that ... off harmful infections, but their role in human health ... on the role of these bacteria, a team of ... tracked fluctuations in the bacterial populations of two research ... the July 25 issue of the journal Genome ...
(Date:7/25/2014)... July 25, 2014 The Conferee Networking ... Topics for Conferee Networking. These two-hour sessions provide a ... meet and resolve problems, discuss new techniques, or brainstorm ... to submit a topic for consideration is August 31, ... . The Conferee Networking committee will review the topics, ...
(Date:7/25/2014)... Biotech Ltd. (Nasdaq: SVA ), a leading provider ... announced that it will release its unaudited financial results for ... on Thursday, August 14, 2014 EDT. The Company will host ... August 15, 2014, at 8:00 a.m. EDT (Friday, August 15, ... Company,s financial results and provide an update on recent corporate ...
Breaking Biology Technology:Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... MINNEAPOLIS and ST. PAUL, Minn., Dec. 11 The ... diabetes research from the,Richard M. Schulze Family Foundation. Goals ... capitalize on the University,s strength in diabetes,research and to accelerate ... with type 1 diabetes. , ...
... Seed Companies to Introduce New Products, Brands. , ... ... Hi-Bred today unveiled a new business strategy to bring its ... of partnerships and new brands. , , , , ,The strategy, ...
... THOUSAND OAKS, Calif., Dec. 11 Ceres, Inc. announced ... seed under its,Blade Energy Crops label. The highly anticipated ... developed specifically as raw materials,for biofuels and biopower. The ... , The company ...
Cached Biology Technology:University of Minnesota Receives $40 Million for Type 1 Diabetes Research 2University of Minnesota Receives $40 Million for Type 1 Diabetes Research 3University of Minnesota Receives $40 Million for Type 1 Diabetes Research 4DuPont Unveils New Strategy to Expand its Seed Business 2DuPont Unveils New Strategy to Expand its Seed Business 3DuPont Unveils New Strategy to Expand its Seed Business 4First Seed Sales of Dedicated Energy Crops Begin 2First Seed Sales of Dedicated Energy Crops Begin 3
(Date:7/25/2014)... of biomedical engineering at the University of Houston, ... and artificial organ development., "Introduction to Tissue Engineering: ... entering into the field of artificial organ development. ... engineering at UH, served as a series editor ... are other published books on the subject of ...
(Date:7/25/2014)... of Adelaide has opened the way for the development of ... In Australia, annual barley production is second only to wheat ... of the most important diseases of barley. , Senior Research ... of special growths on the cell walls of barley plants ... , The research, by the ARC Centre of Excellence in ...
(Date:7/25/2014)... complex congenital central nervous system disease that is ... tubes during the embryonic phase. Many patients have ... and neurocognitive retardation. Such problems decrease the patients, ... at Ankara Physical Medicine and Rehabilitation Education and ... children with SB, using the Pediatric Evaluation of ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2New hope for powdery mildew resistant barley 2
... hospital gowns and bed sheets to match a patient,s skin ... and other health-related skin color changes, according to a new ... a patient, and then sees the patient again later, the ... skin has changed color," said neurobiologist and study leader Mark ...
... The U.S. Environmental Protection Agency (EPA) is making ... releasing a database, called ToxRefDB, which allows scientists and ... toxicity testing results on hundreds of chemicals. ToxRefDB captures ... "Tens of thousands of chemicals are in commerce and ...
... available in German . 48 healthy males participated ... start of the experiment, the other half a placebo. The researchers ... the form of a crying child, a girl hugging her cat, ... express the depth of feeling they experienced for the persons shown. ...
Cached Biology News:Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms 2US Environmental Protection Agency opens access to chemical information 2Hormone spray improves male sensitivity 2
Convenient 10X buffer concentrate used to maximize binding to the solid phase in microwell ELISA. Formulated to provide optimal pH and ionic strength for binding of antibodies and some antigens. Co...
... can be used to label ... covalently bound acridinium NHS ester ... presence of hydrogen peroxide. Acridinium ... used as a detection method ...
A trigger solution for Flashlight labeled materials....
... mobility shift assay (EMSA) is a powerful ... to as gel shift or gel retardation, ... that when subjected to electrophoresis, free DNA ... The Pierce LightShift Chemiluminescent EMSA Kit is ...
Biology Products: