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About Vitreomacular Traction
Numerous conditions are associated with vitreomacular traction which may lead to decreased vision and/or complications. These include macular hole, macular edema (ME) associated with vitreomacular traction, and vitreomacular traction syndrome (VTMS). The only available treatment for these conditions is surgical vitrectomy, in order to induce a posterior vitreous detachment (PVD) and thereby alleviate the vitreomacular traction. Therefore, a pharmacological agent that could relieve vitreomacular traction nonsurgically would be a dramatic advance for the treatment of these conditions, preventing the need for surgery and its associated cost, inconvenience and risk of complications. Macular hole prevalence is approximately 0.14% of general population, leading to estimates of approximately 400,000 cases in the US and of up to 1 million in the industrialized world.
Other potential nonsurgical applications for microplasmin include treatment of macular edema and diabetic retinopathy. Diabetic retinopathy is the leading cause of blindness among working-age adults while diabetic macular edema (DME) is the leading cause of decreased vision in patients with diabetic retinopathy. Around 750,000 patients suffer from DME in the United States alone.
About ThromboGenics
ThromboGenics is a biotechnology company focused on discovery and
development of biopharmaceuticals for the treatment of a range of vascular
and eye diseases. The Company has several programs in Phase II clinical
development including microplasmin, which is being evaluated as a treatment
for vitreoretinal disorders and as a thrombolytic agent for vascular
occlusive diseases, including acute stroke. ThromboGenics is also
developing novel antibody therapeutics in collaboration with BioInvent
International; these include TB-402 (Anti-Factor VIII), scheduled to enter
Phase II clinical development in 2008, and TB-403 (Anti-PlGF), which is
expected to
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| SOURCE ThromboGenics NV Copyright©2007 PR Newswire. All rights reserved |
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