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ThromboGenics N.V.: Business Update
Date:11/6/2008

enics announced that a group of

private investors based in Belgium had together acquired an 8% stake in

the Company. This stake was purchased from Biggar Limited, a charitable

foundation that is ThromboGenics' largest single shareholder. Biggar

now holds a 9.8% stake in ThromboGenics, and has informed the Company

that it intends to remain an important shareholder in ThromboGenics for

the long term.

- ThromboGenics shares entered the Bel Mid Index on 1 October

2008, following the quarterly review of the Belgian indices by

Euronext. The elevation of ThromboGenics to the Bel Mid Index reflects

the significant progress that the Company has made since its IPO in

2006.

Corporate Update

- On 1 September, Patrik De Haes, MD, formerly the Company's

Chief Operating Officer, was appointed to succeed Professor Desire

Collen as the Company's new Chief Executive Officer. Dr. De Haes will

be proposed to become a member of the Board of Directors of

ThromboGenics at the next General Meeting. In the meantime, he will be

invited to participate in Board meetings.

ThromboGenics will continue to benefit from Professor Collen's significant scientific and drug discovery knowledge. Professor Collen will remain Chairman of ThromboGenics' Board of Directors.

Pipeline Update

Microplasmin in Eye Disease

ThromboGenics is working to finalise its Phase III clinical trial program for microplasmin in the treatment of back of the eye disease, following a successful End of Phase II meeting with the FDA. The initial indication planned for the program is the nonsurgical resolution of vitreomacular adhesion. Two placebo controlled trials are planned, one in the U.S. and one combined European and North American trial. Together it is anticipated that the two trials will recruit a total of approximately 640 patients, with the first trial ex
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SOURCE ThromboGenics NV
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5. ThromboGenics N.V. - Business Update
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