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ThromboGenics N.V. - Business Update
Date:5/13/2008

eye diseases such as retinal detachment, diabetic vitreous hemorrhage and macular hole. It is estimated that 600,000 vitrectomies are carried out annually worldwide.

Vitrectomy is used to induce a posterior vitreous detachment (PVD), which involves removing the vitreous from the eye. As microplasmin is a proteolytic enzyme, it is able to cleave the molecular structures which link the vitreous to the retina, meaning that it could facilitate, and in some cases even avoid, vitrectomy and therefore induce PVD without the risks inherent in the current surgical procedure.

The MIVI III trial, which has recruited a total of 125 patients, is designed to assess the safety and efficacy of administering microplasmin intravitreal injection 7 days prior to vitrectomy.

- ThromboGenics completed patient enrolment for its Phase II MITI IV trial

Microplasmin is also being studied for the treatment of acute ischemic stroke. In this indication, the fact that it is a direct-acting thrombolytic agent (breaks down blood clots) and is independent of plasminogen means that it could restore blood flow efficiently for a longer period after the stroke event, and with potentially fewer side-effects than other thrombolytic agents. The MITI IV study is placebo controlled and is evaluating the safety and preliminary efficacy of microplasmin in three different doses when administered intravenously to acute stroke patients between four and twelve hours after the onset of the stroke. This trial has recruited a total of 40 patients.

- In January, ThromboGenics announced that its novel anti-cancer antibody TB-403 had begun its initial Phase I clinical trial in Denmark.

TB-403 (Anti-PIGF) is a potential breakthrough in the treatment of cancer. It is a humanized monoclonal antibody that blocks the formation of the new blood vessels that are needed by solid tumours to support their growth. TB-403 therefore has the potential to minimise the growth and spread of ca
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Related biology technology :

1. ThromboGenics - Business Update and Interim Results for the Seven Month Period Ending 30 June 2007
2. ThromboGenics Announces Successful Completion of Technology Transfer to Bharat Biotech for Production of Novel Thrombolytic Agent
3. ThromboGenics and BioInvent Announce Successful Completion of Phase I Clinical Trial of the Anticoagulant TB-402
4. ThromboGenics and BioInvent Announce Publication of Exciting Data on a Novel Class of Angiogenesis Inhibitors in Cell
5. ThromboGenics Presents Results of the Vitreomacular Traction Trial (MIVI IIT) at the American Society of Retina Specialists Annual Meeting
6. ThromboGenics Presents Results of the Phase I Trial of TB-402 at the Prestigious American Society of Hematology Annual Meeting
7. ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer
8. ThromboGenics Announces 2007 Full Year Results
9. ThromboGenics Completes Patient Enrolment of MITI IV Trial, a Phase II Study Evaluating the Safety and Preliminary Efficacy of Microplasmin in the Treatment of Acute Stroke
10. Boston Scientific to Explore Sale of Cardiac Surgery and Vascular Surgery Businesses
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