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ThromboGenics Announces Business Update and 2008 Full Year Results
Date:3/12/2009

ed that the most effective dose of microplasmin studied (125 ÿ¼g) was able to resolve the underlying disease in approximately 30% of patients within 1 week of treatment, removing the need for surgical intervention in these patients.

Microplasmin - Eye Disease: Phase III clinical program to evaluate non surgical treatment of patients with vitreomacular adhesion. In January 2009, ThromboGenics announced the start of the Phase III clinical program of microplasmin for the non-surgical treatment of back of the eye disease. The Phase III program comprises two clinical trials, taking place in the United States (TG-MV-006 trial) and combined Europe and US (TG-MV-007 trial). The initial indication for both of the Phase III microplasmin trials is the non-surgical treatment of focal vitreomacular adhesion. Both of these trials will use the 125ÿ¼g dose of microplasmin and include 320 patients each. Microplasmin for Vascular Disease - Encouraging Phase II results in acute ischemic stroke. In September, Professor Vincent Thijs, KULeuven, presented the results from this 40 patient study at the World Stroke Congress in Vienna, Austria. It remains ThromboGenics' intention that it will only move forward with the development of microplasmin for the treatment of stroke in conjunction with a partner.

TB-402 - Anti-coagulant: Begins Phase II trial in patients undergoing orthopaedic surgery. In February 2009, ThomboGenics announced that the first patient had been enrolled in the Phase II trial with their long-acting anticoagulant TB-402 for the prophylaxis of Deep Vein Thrombosis (DVT) following orthopaedic surgery. TB-402, which is given as a single injection post surgery, could overcome the major drawbacks such as bleeding and the need for extensive patient monitoring associated with current anti-coagulant therapy.

TB-403 - Anti-cancer: Positive results announced in Phase Ia study with TB-403 and start of Phase Ib st
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Related biology technology :

1. ThromboGenics and BioInvent Start Phase II Trial of TB-402, a Novel, Long Acting Anticoagulant for Deep Vein Thrombosis (DVT) Prophylaxis
2. ThromboGenics N.V.: Business Update
3. ThromboGenics Announces Half Year Results 2008
4. ThromboGenics Appoints Dr. Patrik De Haes as Chief Executive Officer
5. ThromboGenics Announces Private Investors Acquire 8% Stake in the Company
6. ThromboGenics and BioInvent Announce a Strategic Alliance With Roche for TB-403, a Novel Anti-Cancer Antibody
7. ThromboGenics N.V. - Business Update
8. ThromboGenics Completes Patient Enrolment of MITI IV Trial, a Phase II Study Evaluating the Safety and Preliminary Efficacy of Microplasmin in the Treatment of Acute Stroke
9. ThromboGenics Announces 2007 Full Year Results
10. ThromboGenics and BioInvent Receive Approval to Begin Clinical Trials of TB-403 for the Treatment of Cancer
11. ThromboGenics Presents Results of the Phase I Trial of TB-402 at the Prestigious American Society of Hematology Annual Meeting
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