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ThromboGenics - Positive Microplasmin Phase II Data Published in Ophthalmology
Date:2/9/2010

LEUVEN, Belgium, February 9 /PRNewswire-FirstCall/ --

- Paper Examines the Potential of Microplasmin to Improve the Treatment of a Range of Back of the Eye Diseases

ThromboGenics NV (Euronext Brussels: THR), a biopharmaceutical company focused on the discovery and development of innovative treatments for eye disease, vascular disease and cancer, announces today that the positive microplasmin Phase II trial results, evaluating the product's efficacy and safety in patients who require vitrectomy, have been published in the prestigious American Academy of Ophthalmology's Journal, Ophthalmology, the leading journal for the vitreoretinal community.

A paper entitled "A Placebo-Controlled Trial of Microplasmin Intravitreous Injection to Facilitate Posterior Vitreous Detachment Before Vitrectomy" has been published online ahead of print in Ophthalmology. This publication covers the Phase II trial (MIVI III) with microplasmin, with the objective of evaluating the efficacy and safety of intravitreal microplasmin in facilitating the separation of the vitreous from the retina. The separation of the vitreous from the retina is used to treat a range of back of the eye disorders and is achieved currently via a surgical procedure called a vitrectomy.

The paper showed that the highest dose of microplasmin (125microg) led to a greater likelihood of induction and progression of PVD than placebo injection. Moreover, patients in this dose group had a statistically significant improvement in visual acuity at the 35-day timepoint when compared to placebo. Also, the trial showed that patients receiving microplasmin were significantly more likely not to require vitrectomy surgery to resolve their underlying disease.

The results outlined in the article highlight that microplasmin could be a pot
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SOURCE ThromboGenics NV
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