Navigation Links
Three PDX (Pralatrexate) Studies Presented at the 2007 AACR-NCI-EORTC Conference
Date:10/25/2007

MTD in NSCLC Identified; Phase 2 Study Planned

WESTMINSTER, Colo., Oct. 25 /PRNewswire-FirstCall/ -- Allos Therapeutics, Inc. (Nasdaq: ALTH), a biopharmaceutical company focused on the development and commercialization of small molecule therapeutics for the treatment of cancer, today announced that results from three PDX studies were presented as posters during the 2007 AACR-NCI-EORTC conference held October 22-26, 2007 in San Francisco, California. The posters described the effects of PDX (pralatrexate) in patients with non-small cell lung cancer (NSCLC), in patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) and Hodgkin's disease, and in human cancer models in vivo and in vitro.

PDX in NSCLC (Phase 1)

The poster entitled "Phase 1 study of the antifolate pralatrexate when given with vitamin B12 and folic acid supplementation in patients with advanced non-small cell lung cancer (NSCLC)" presented results of this Phase 1 dose ranging study. In the study, a total of 22 patients with relapsed or refractory NSCLC were treated at doses of 150 to 325 mg/m2 of PDX. The maximum tolerated dose (MTD) was determined to be 270 mg/m2, which is twice that observed in a previous Phase 1 study in which PDX was administered without vitamin supplementation. Clinically significant radiologic responses were observed. Greater than 50% of patients (13/22) received two or more prior treatment regimens. Based on PDX clinical experience to date, the Company plans to initiate a randomized Phase 2 study of PDX in patients with NSCLC.

PDX in NHL (Phase 1/2)

The poster entitled "A Phase '2-1-2' Study of Two Different Doses and Schedules of Pralatrexate, A High Affinity Substrate for the Redu
'/>"/>

SOURCE Allos Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. The TripleMaster PCR System for three different amplifications
2. Cloning Based on Efficient Three-Fragment Assembly DNA Ligation
3. Three Micron TSK-GEL ODS-100V Columns for High Throughput LCMS
4. Three finalists named for UW-Madison CIO
5. Three state businesses receive technology grants
6. Leading cancer institute to install three TomoTherapy systems
7. Waukesha considers wireless bids from three firms
8. Computerworld top 100 includes three Wisconsin CIOs
9. 30 days to success: Three simple steps to create your own international startup
10. Three firms get state tech development grants
11. Three more Wisconsin firms to present at venture forum

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2009)... -- DSM Pharmaceutical Products today announced th...ix, Saint Jean D,Illac, France, where DSM will be ...er for Galenix commercial products on a global bas...ness development opportunities co-marketing Galeni...h of Galenix in drug product development and clini...
(Date:11/5/2009)...swire-FirstCall/ -- ThermoGenesis Corp. (Nasdaq: ...for processing and storing adult stem cells, today...2010. ,, For the quarter ended September 30, 20... a 15 percent increase over revenues of $4.5 milli...id the key contributors to the growth in revenues ...
(Date:11/5/2009)...Call/ -- Transgenomic, Inc. (OTC Bulletin Board: T...rter ended September 30, 2009. The Company,s finan...ow. ,, Third Quarter 2009 ,, The Company r...for the third quarter of 2009 as compared to a net... quarter of 2008. ,, Net sales were $5.0 milli...
(Date:11/5/2009)...-FirstCall/ -- Cepheid (Nasdaq: CPHD ) today anno...following investor conferences, and invited invest... Credit Suisse Healthcare Conference, Phoenix, AZ...0 a.m. Mountain Time, NASDAQ OMX ... Tuesday, 1 December, 2009 at 10.45 a.m. Gree...
Breaking Biology Technology:DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 2DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 3ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 2ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 3ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 4ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 5ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 6ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 7ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 8Transgenomic, Inc. Reports Third Quarter 2009 Results 2Transgenomic, Inc. Reports Third Quarter 2009 Results 3Transgenomic, Inc. Reports Third Quarter 2009 Results 4Transgenomic, Inc. Reports Third Quarter 2009 Results 5Transgenomic, Inc. Reports Third Quarter 2009 Results 6Transgenomic, Inc. Reports Third Quarter 2009 Results 7Cepheid to Webcast Upcoming Financial Presentations 2
...rd Wave Technologies this week reported the best ...story, wrapping up a year in which it met or excee...d Wave reported total revenues of $46.5 million an...cember 31, compared to total revenues of $36.3 mil...The company reported total revenues of $8.1 millio...
...r community when power stands still? , ,A. Things... wag; its always someone elses fault. , ,C. Young...wn initiative. , ,If you answered "C," you might ...r for the first time in our companys seven year hi.... Unwilling to wait for their communitys tradition...
...usiness. Whoa! Put down those pitchforks and torc...start some kind of technology for technology,s sak... people who are in the business of building and se...er, in the last twenty or so years as wave after w...orld, it became easy, accepted and even fashionabl...
Other Biology Technology:Third Wave boosts numbers in latest report 2Third Wave boosts numbers in latest report 3Third Wave boosts numbers in latest report 4Lead, follow or get out of the way 2Stay in the driver's seat, but don't ditch technology 2Stay in the driver's seat, but don't ditch technology 3
(Date:11/8/2009)...earchers at Purdue University have discovered a ne...pinal cord injuries using nano-spheres that could ...nt. , The synthetic "copolymer micelles" are dru..., or roughly 100 times smaller than the diameter o...ying how to deliver drugs for cancer treatment and...
(Date:11/8/2009)... FOR ADULTS WITH INTELLECTUAL DISABILITIES: AN OPP...rsity study involving adults with intellectual dis...rsonal health knowledge after taking a semi-weekly...ernationally accepted term for mental retardation,...nactivity and preventable chronic diseases compare...
(Date:11/6/2009)...rsary this month of the publication of On the Orig...l Sciences (AIBS) is publishing open access two pe...historic insights into evolution. , The two artic...ornia, Berkeley, and James T. Costa of Western Car...ut Charles Darwin," appeared in the October issue ...
Breaking Biology News(10 mins):Findings show nanomedicine promising for treating spinal cord injuries 2Findings show nanomedicine promising for treating spinal cord injuries 3Indiana U. at APHA: Studies about health education for people with ID, stability balls at work 2Indiana U. at APHA: Studies about health education for people with ID, stability balls at work 3Many Childhood Cancer Survivors Never Marry 59131 1Many Childhood Cancer Survivors Never Marry 59131 2Swine Flu 28H1N1 29 Virus Destroyed by Innovative Air Treatment Technology 59127 1Swine Flu 28H1N1 29 Virus Destroyed by Innovative Air Treatment Technology 59127 2ABAXIS Announces Launch of the First Fully Automated Canine Wellness Profile That Includes a Canine Heartworm Antigen Test 5321 1ABAXIS Announces Launch of the First Fully Automated Canine Wellness Profile That Includes a Canine Heartworm Antigen Test 5321 2ABAXIS Announces Launch of the First Fully Automated Canine Wellness Profile That Includes a Canine Heartworm Antigen Test 5321 3ABAXIS Announces Launch of the First Fully Automated Canine Wellness Profile That Includes a Canine Heartworm Antigen Test 5321 4
...ientists has used gene therapy in two separate stu...ents in monkeys and rats with a drug-induced form ...online in the scientific publications Brain and Th...ne strategy to halt Parkinson,s disease at its ons...ide effects that occur when treating the disease i...
... reveal how an,evolutionary innovation involving t...ven rise to a deep-seated dependency between them ...new work illustrates how genetic exchange through ... a system of interdependence at a,high level of bi...on of,worker ants for both species. , Millions,of ...
...he journal Nature that the "missing" genes for tRN...ogether sequences in distant parts of the DNA geno...n the Department of Molecular Biophysics and Bioch...sm with a known genome sequence. Nanoarchaeum equi... the Archaea containing organisms that are primiti...
Other Biology News:Gene Therapy For Parkinson's Disease Moves Forward In Animals 2Gene Therapy For Parkinson's Disease Moves Forward In Animals 3Gene Therapy For Parkinson's Disease Moves Forward In Animals 4Ants Genetic Engineering Leads To Species Interdependency 2Researchers find missing genes of ancient organism 2
...rs combine high durability and capacity with unequ...nced heavy-duty mechanism prevents vibration, allo...alance loads. Every other part, from the large rub...chined aluminum platform is designed to last throu...
RapidStak 2 (requires 4 staks, not included) from Thermo Scientific
Small bottle, 150 x 35mm from Thermo Scientific
Extra large bottle, 300 x 70mm from Thermo Scientific
Biology Products: