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Three Nephrology TreatmentTrends Publications from BioTrends Provide a Comprehensive View of Bone and Mineral Metabolism Practice Patterns Around the Globe
Date:1/16/2010

increase as Renvela becomes more widely available in the EU markets. In the US market, the conversion from Renagel to Renvela has already been quite strong with over 90% of Nephrologists now prescribing the product and sevelamer share division favoring Renvela over Renagel.

In the PTH modifier market, there are a number of regional variations. The availability and use of active vitamin D brands, for example, differs, with Abbott's Zemplar holding the market leader position among hemodialysis patients in the US and Spain, whereas in Canada calcitriol holds the market leader position in both dialysis and CKD-ND. Alfacalcidiol leads the market in the UK, whereas in Germany, calcitriol and alfacalcidiol almost evenly divide the market. There are also differences by region in terms of when active vitamin D should be used - only when PTH is elevated or in low doses, regardless of PTH. There are however, some market similarities. In both the US and Europe, the use of nutritional vitamin D is projected to increase. In all markets, use of Amgen's Sensipar / Mimpara tends to be limited to dialysis patients. Use of Sensipar / Mimpara is, however, higher in the US than in Europe overall, but use in the US has been relatively flat while use in Europe has been growing. There are significant differences though in uptake of the product within Europe from a low of 9% market share in the UK to more than one-third of patients on the product in Spain. It will be interesting to see the bone and mineral metabolism market continue to evolve, particularly with the release of the KDIGO CKD-MBD guideline, which a number of Nephrologists believe will positively impact their use of phosphate binders, active vitamin D and cinacalcet.

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