PHILADELPHIA, July 26, 2012 /PRNewswire/ -- The Intellectual Property & Science business of Thomson Reuters, the world's leading source of intelligent information for businesses and professionals, today announced a partnership with CHDI Foundation, Inc. to develop systems biology tools for Huntington's disease (HD) research. HD is a devastating neurodegenerative disorder that affects muscle coordination and leads to gradual cognitive decline and dementia; there are currently no effective treatments available. The collaboration will include reconstruction and analysis of causal networks underlying HD mechanisms and building a comprehensive collection of HD pathology pathway maps to assist researchers worldwide.
"Building a clearer, more detailed understanding of Huntington's disease that leads to the development of therapies is CHDI's top priority," said Keith Elliston, vice president of systems biology at CHDI. "We are very pleased to be collaborating with Thomson Reuters to provide the whole HD research community with valuable tools that will further our knowledge of the disease and bring us closer to effective therapeutic options for patients."
One of the central goals of the MetaMiner Partnership will be to identify disease mechanisms through network analysis of gene expression data in HD patients with different numbers of CAG repeats in the huntingtin (HTT) gene. The number of CAG repeats is a predictor of the age of disease onset.
A second objective of the collaboration will be to build pathology pathway maps for disease mechanisms, continuing the work of MetaMiner™ for HD, a program that focuses on HD pathway reconstruction. This project, a collaborative effort between Thomson Reuters, as well as selected pharmaceutical companies and universities, has generated 15 specific HD pathway maps. Thomson Reuters builds causal networks and p
|SOURCE Thomson Reuters|
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