Navigation Links
This week in Molecular Biology and Evolution: A step ahead of influenza, honeybee sex
Date:10/29/2013

Staying a step ahead of influenza

Every fall, the latest batch of flu vaccines attempts to keep society a step ahead of the evolution of the flu virus. Heroic worldwide surveillance efforts have avoided a repeat of the 1918 flu pandemic, but as shown in the recent H1N1 outbreak, viruses can still outwit even the best public health efforts.

During the H1N1 outbreak, antiviral drugs offered the only hope against emergent flu strains. Two drug classes: adamantanes (FDA approved in 1966) and neuraminidase inhibitors (oseltamivir, FDA approved in 1999) represent two classes of drugs that target viral an ion channel and a cell surface antigen, respectively, hereby preventing or treating infection.

In an ambitious study, the authors attempt to trace drug resistance against all strains of the flu by using an extensive influenza virus database containing all known genetic sequence information (70,000 complete nucleotide sequences) for influenza strains. Using a phylogenetic approach, authors Vanessa Garcia and Stphane Aris-Brosou examined the evolutionary history of antiviral drug resistance. "Although the approaches employed in our study are not novel in themselves, the scale of the analyses is unprecedented and allowed us to track in public databases the dynamics of all known mutations involved in drug resistance", reported the senior author.

How does the virus outwit two leading antiviral therapies? Widespread use of these drugs has led to the emergence of drug resistance. Most disconcerting, recent "dual resistance" viruses dodge both drugs, leaving us defenseless against the virus. While adamantane resistance mutations appeared readily, it took 15-38 years after FDA approval to emerge, but emerged 3 times, whereas, the less spontaneous oseltamivir mutations took at most 7 years, serving as a public health cautionary tail. The authors support the judicious use of antiviral drugs as a last line of defense against influenza
'/>"/>

Contact: Joe Caspemeyer
MBEpress@gmail.com
480-258-8972
Molecular Biology and Evolution (Oxford University Press)
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. EU sponsors fabrication of molecular electronic components on the sub-nanometer scale
2. Personal Genome Diagnostics and MolecularMD Collaborate to Provide Advanced Genomic Testing Services to Cancer Drug Developers
3. This week in Molecular Biology and Evolution
4. Molecular Diagnostics in Genetic Testing - 2013 Study Analyzes the Size and Growth of the Molecular Diagnostics in Genetic Testing Market
5. Biotech Industry Executives Summit (10/8) to Advance the Supply Chain with Focus on Serialization, Strategic Sourcing, Clinical Supply and Molecular Diagnostics
6. Rising Interest in Molecular Biology Research Drives Demand for qPCR and dPCR Instrumentation, According to a Soon to be Released Report by Global Industry Analysts, Inc.
7. MRIGlobal Engages Industry Expert in Expansion of Molecular Diagnostic Division
8. Reproducing natures chemistry: Researchers alter molecular properties in a new way
9. Curemark Enters into Research Collaboration with The Molecular Sciences Institute (VTT/MSI)
10. Molecular Cytogenetics Market is Expected to Reach USD 1.97 Billion Globally in 2019: Transparency Market Research
11. Molecular Diagnostics: Technologies, Markets and Companies - 2013 Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 A study presented ... safety and efficacy of CSL Behring,s C1 Inhibitor ... transplants in highly sensitized patients. C1-INH is a ... complement system. The study shows that ... in the levels of complement components 3 and ...
(Date:7/30/2014)... Canada (PRWEB) July 30, 2014 ... available in health services research for a relatively ... upswing in interest regarding the use of these ... practice conditions. , By combining today’s powerful computer ... the digital era, ‘big data’ holds significant promise ...
(Date:7/30/2014)... July 30, 2014   Wyle has ... Integrated Lifecycle Mission Support Services (FILMSS) contract awarded ... Under the terms of the contract, Wyle will ... Moffett Field, Calif. In particular, Wyle will provide ... development projects on the International Space Station and ...
(Date:7/30/2014)... 2014 BCC Research ( http://www.bccresearch.com ) ... Enzymes in Industrial Applications , the global market for ... billion by 2018, registering a five-year compound annual growth ... be recorded in the detergent enzyme segment with a ... technology has influenced almost every sector of industrial activity, ...
Breaking Biology Technology:Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3
... 10, 2011 PAREXEL International Corporation (Nasdaq: PRXL ... on Monday, January 31, 2011 after the close of the ... at www.PAREXEL.com and on the PR Newswire website ... conference call and live webcast at 10:00 a.m. EST on ...
... Wash., Jan. 10, 2011 BioLife Solutions, Inc. (OTC Bulletin ... update today by its Chairman and Chief Executive Officer Mike ... 2010 on a number of strategic growth initiatives.   ... to report preliminary record revenue of $575,000 for the fourth ...
... DD ) has entered into a definitive ... and specialty food ingredients company, for $5.8 billion in ... debt.  Upon closing, this transaction would establish DuPont as ... that address global challenges in food production and reduced ...
Cached Biology Technology:PAREXEL Announces Date of Second Quarter Fiscal Year 2011 Earnings Release and Conference Call 2BioLife Solutions CEO Issues 2010 Corporate Update 2BioLife Solutions CEO Issues 2010 Corporate Update 3DuPont to Acquire Danisco for $6.3 Billion 2DuPont to Acquire Danisco for $6.3 Billion 3DuPont to Acquire Danisco for $6.3 Billion 4
(Date:7/31/2014)... , July 31, 2014 Biometrics ... and innovative smart technologies; companies turn towards digital currency: ... EBAY ), Amazon.com Inc. (NASDAQ: AMZN ), ... (NASDAQ: GOOG ) and Microsoft Corporation (NASDAQ: ... focused on the growing m-commerce market, announces a video ...
(Date:7/30/2014)... paving the way for a breakthrough that may ... exposed to poisonous chemicalsparticularly those in pesticides and ... current issue of the journal ChemBioChem ... compounds commonly used in pesticides and warfare agents. ... of Engineering Associate Professor of Chemical and Biological ...
(Date:7/30/2014)... that David L. Kaplan, Ph.D., will head the brand-new, ... as editor-in-chief. With the first issue slated for publication ... research in the rapidly burgeoning field of biomaterials, the ... with living or biological systems. , "This new journal ... the field of biomaterials over the past decade and ...
Breaking Biology News(10 mins):Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6Engineering a protein to prevent brain damage from toxic agents 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... brain study finds major differences between women with serious ... crucial to stress and emotions. , The study ... specific alterations within the brain -- specifically in the ... the brain's natural pain and stress-reduction system. The findings ...
... at Harvard University have developed a computer model ... and predict how small proteins fold into three-dimensional, ... better understand the abnormal protein aggregation underlying some ... evolved and how proteins recognize correct biochemical partners ...
... The golden age of dinosaur discovery is yet upon us, ... In a forthcoming issue of the Proceedings of the National ... the diversity of discoverable dinosaurs upward by 50%, offering a ... found. His findings also add evidence that dinosaur populations ...
Cached Biology News:New brain-chemistry differences found in depressed women 2New brain-chemistry differences found in depressed women 3Comprehensive model is first to map protein folding at atomic level 2Good times ahead for dinosaur hunters, according to U of Penn scientist's dinosaur census 2Good times ahead for dinosaur hunters, according to U of Penn scientist's dinosaur census 3
... Experion HighSens analysis kit for 25 chips ... perform high-sensitivity RNA analysis (at picogram levels) ... kit includes 25 RNA HighSens microfluidic chips, ... x 20 microliters RNA HighSens stain, 20 ...
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... The Experion StdSens analysis kit for ... required to perform standard-sensitivity RNA analysis (at ... system. This kit includes 25 RNA StdSens ... gel, 2 x 20 microliters RNA StdSens ...
... 2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one White ... GAS. A brain-permeable and water soluble pyrimidinone ... NAD + -competitive inhibitor of PARP (IC ... nM for rhPARP1 and rmPARP2, respectively) with ...
Biology Products: