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Therapeutic Revolution in Dermatology
Date:4/29/2010

Can several PDT sessions be applied if lesions recur?

Professor Lasse Braathen: Yes, because phototherapy involves no ionizing toxicity. When lesions reappear, the patient can again be offered treatment by PDT, and the treatment can be repeated as many times as necessary. In rare cases of failure, all therapeutic options are available because of the absence of local or general toxicity from PDT, with no loss of the patient's chances. When skin lesions are extensive, treatment by PDT makes it possible to pinpoint the "PDT-resistant" lesions that require some other therapeutic approach.

Are there other possible uses of PDT?

Professor Lasse Braathen: Yes, but they have not been validated by the AMM; some skin lymphomas can benefit from it, with remarkable effectiveness. PDT can also be used preventively in transplant patients, in whom skin cancer appears in 15% of cases after the transplant.

Cosmetic use of PDT is also practiced outside AMM for its "rejuvenating" effect. Patients presenting an actinic keratosis also benefit from this positive secondary effect of PDT.

The relatively recent concept of "field cancerization" could become an indication for PDT. A field cancerization around actinic keratosis lesions forms an area with pre-neoplastic anomalies and infra-clinical and multifocal genetic mutations that can evolve into primitive new tumours and local recurrences. It seems logical to treat all of this area preventively rather than to treat an isolated lesion. Applying Metvix makes it possible to more easily see the non-visible lesions, which glow under black light. This method is very much appreciated by patients, who can use it to see their skin risk and easily understand the need for treatme
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SOURCE European Society for Photodynamic Therapy (Euro PDT)
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