Navigation Links
Therapeutic Cells Derived From Reprogrammed (iPS) Stem Cells Display Early Aging
Date:2/10/2010

WORCESTER, Mass., Feb. 11 /PRNewswire-FirstCall/ -- Advanced Cell Technology, Inc. (OTCBB: ACTC) reported that a range of therapeutic cell types obtained from induced pluripotent stem (iPS) cells exhibit abnormal expansion and early cellular aging.  The research, which appears online (published-ahead-of- print) in the journal STEM CELLS by ACT and its collaborators at Stem International (SCRMI), Harvard Medical School, and the University of Illinois, compares a variety of replacement cell types derived from human iPS cells to their embryonic stem (ES) cell counterparts. 

The research shows that human iPS cells can generate blood, vascular and retinal cells with characteristics similar to those derived from ES cells, but with a dramatic decreased efficiency.  However, in distinct contrast to the ES cell derivatives, major differences were observed in cells derived from iPS cells, including significantly increased cell death (apoptosis), severely limited growth and expansion capability, as well as a substantially decreased capacity to generate blood progenitors.  After further differentiation into red blood cells, over a thousand-fold difference in expansion capability was observed in iPS cells versus ES cell progenitors.  Although vascular cells derived from iPS cells were capable of forming capillary-like structures, the cells also demonstrated early cell aging (senescence). Similarly, retinal cells derived from iPS cells also displayed early signs of aging.  

"Before clinical application, it will be necessary to determine the cause and extent of such abnormalities, and whether they also occur in stem cells generated using different reprogramming methods" said Robert Lanza, M.D., Chief Scientific Officer at ACT, and senior author of t
'/>"/>

SOURCE Advanced Cell Technology, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. United Therapeutics Corporation to Announce Fourth Quarter and Annual 2009 Financial Results Before Market Open on Tuesday, February 16, 2010
2. Corgenix and Tulane Announce Award of Additional NIH Contract to Expand Lassa Fever Research Towards Development of Vaccines and Improved Therapeutic Agents
3. Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board
4. Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference
5. Aegera Therapeutics Initiates a Randomized Phase 2 Study with AEG35156 for the Treatment of Hepatocellular Carcinoma
6. Oxygen Biotherapeutics, Inc. Outlines Plans for New Products During Investor Conference Presentation
7. The Honorable Tommy G. Thompson Joins the United Therapeutics Corporation Board of Directors
8. Cell Therapeutics Commits to PhRMAs Code on Interactions With Healthcare Professionals
9. WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities
10. Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement
11. Dennis Winger Joins Nektar Therapeutics Board of Directors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company ... Images such as the Fonz in a lab coat and Large Marge have been ... spectroscopy field. , FireflySci is proud to be the only cuvette manufacturer is ...
(Date:8/27/2015)... Aug. 27, 2015 /PRNewswire/ - Portage Biotech Inc. ... and Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced ... I study of BHV-0223, a glutamate modulating agent. ... BHV-0223 and recently obtained clearance from the U.S. ... human testing. Portage holds 54% equity interest in ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience International ... of the Japan Society of HTLV-1, held this week ... The purpose of the Society is to promote research ... development of medical technology and research related to these ... "HUYA is proud to support this prestigious ...
(Date:8/27/2015)... , Aug. 27, 2015 In ... by FedEx, UPS and The US Postal Service ... specimens classified as ,select agents, by the CDC, ... of handling these sensitive shipments. Marken ... transportation regulations, trained and certified personnel to ensure ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... 2009 (BRONX, NY) An innovative drug-delivery system ... shows promise for topical treatment of erectile dysfunction (ED), ... Einstein College of Medicine of Yeshiva University. ... of animals, could potentially prevent side effects associated with ...
... , , MENLO PARK, Calif., Sept. ... announced today that John J. Young, Jr. has been elected to ... become the SRI Board,s tenth member, joining a group that includes ... "Throughout his career, John has been a champion of ...
... 18 London Genetics Limited, which,expedites pharmacogenetic partnerships ... in genetics research, announces today,several prestigious appointments to ... include Dr Barrie Ward as Chairman, will drive ... importance of pharmacogenetics in drug,development increases. They bring ...
Cached Biology Technology:Topical erectile dysfunction therapy shows promise 2Topical erectile dysfunction therapy shows promise 3John J. Young, Jr. Joins SRI Board of Directors 2John J. Young, Jr. Joins SRI Board of Directors 3New Appointments at London Genetics to Drive Strategy Forward 2New Appointments at London Genetics to Drive Strategy Forward 3New Appointments at London Genetics to Drive Strategy Forward 4
(Date:8/18/2015)... , Aug. 18, 2015  Navitas today ... contributor to the Submission Content Management webinar ... a non-profit forum. Dedicated to the Implementation of ... neutral platform for industry, vendors, health authorities, ... and work towards a standard method of ...
(Date:8/12/2015)... SPRINGS, Florida , August 12, 2015 ... the pace of mobile payment innovation and advanced biometrics ... to replace the way consumers rely on using their ... ahead with reinventing the future for payment services led ... (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
(Date:8/10/2015)... Germany , August 10, 2015 ... in Eye Tracking Technology for more than two decades, ... Platform for integration into all consumer display formats. The ... seamless integration of eye tracking into consumer tablets, laptops, ... reality smart glasses. Omnivision,s leading sensor technology contributes to ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... mantle of summer pest, cicadas are perhaps the most curious. They ... they taste good in chocolate, but as the drowning din of ... less if they emerged more often. Cicadas are unique among ... why would anyone actually want to replicate theses sounds? A ...
... rhythms can boost the body,s ability to fight intestinal ... suggests that targeted treatments may be particularly effective for ... strong immune system response governed by circadian genes. It ... pattern as experienced by, say, night-shift workers or ...
... a human gene for schizophrenia and exposed to lead ... their brains consistent with schizophrenia. Scientists at Columbia University,s ... University School of Medicine say their findings suggest a ... factor, and open an avenue to better understanding the ...
Cached Biology News:Secrets of the cicada's sound 2Secrets of the cicada's sound 3Circadian rhythms control body's response to intestinal infections, UCI-led study finds 2Lead acts to trigger schizophrenia 2