Navigation Links
The most natural drug
Date:4/30/2008

In the fight against infection, the human immune system isnt ready for a war.

Vaccines push the immune system to create defenses against illness, but they take time to work. A new process developed by scientists at the Oklahoma Medical Research Foundation (OMRF) and Emory University stands to revolutionize the process.

In an advance online publication in Nature, the researchers describe a method that can identify and clone human antibodies specifically tailored to fight infections. The new technology holds the potential to quickly and effectively create new treatments for influenza and a variety of other communicable diseases.

When an infection invades, the immune system goes to work manufacturing antibodies to fight it. Most of the antibodies created will have no effect, but a very few will bond to the invader and replicate to neutralize the enemy.

The new process develops a smart bomb for the immune system, using fully human monoclonal antibodies specifically designed to fight the infection without doing any harm to the body. The work was led by OMRFs Patrick Wilson, Ph.D., and J. Donald Capra, M.D., and Emorys Rafi Ahmed, Ph.D., and Jens Wrammert, Ph.D.

In the past, it took years of work and great expense to create what are known as monoclonal antibodieslab-produced antibodies derived from a single line of cells. It was kind of the needle in a haystack approach, said OMRFs Wilson, senior author on the paper. The problem is they couldnt pick the cells that made the antibodies against the pathogens that you wanted to fight.

A second method, making hybrid antibodies from mouse B cells (white blood cells that produce infection-fighting antibodies), is faster but more dangerous. If the proteins in the hybrid antibodies werent compatible, the body could reject the antibodies or react with them in unforeseen ways.

The new process doesnt use traditional antibody derivation methods or human-mouse hybrids. Instead, the OMRF and Emory researchers isolated antibody-secreting cells (plasma cells) from people who had received the influenza vaccine, then cloned the antibody genes from these cells.

We can recognize which cells are made and then make antibodies from them directly, Wilson said. Its a rapid and efficient way to make fully human antibodies.

While the research is aimed at combating influenza, it can be used to create treatments for any conditionsuch as anthrax or smallpoxfor which there is already a vaccine. Antibodies might also be produced from the immune responses of people with active or chronic infections. This technology has the potential to serve as therapy for someone who is already infected or provide passive immunity to protect against future infection.

Vaccines can activate the immune system, but they need time to take effect, and many offer less than 100 percent protection and carry risks of side effects, OMRF President Stephen Prescott, M.D., said. With further research and testing, this new method might allow a nurse going into the center of an outbreak to receive a shot to keep her safe from infection. Soldiers in the field could keep a shot of anti-anthrax in their packs in case of a biological attack.

With more research, this new technology could also be key to fighting diseases such as multiple sclerosis and cancer, Prescott said.

Wilson and his clinical collaborator, OMRFs Judith James, M.D., Ph.D., are currently working to make more antibodies from other infectionsincluding hepatitis C, pneumococcal pneumonia, and anthrax. Theyre also seeking a partner to help produce large quantities of the influenza antibodies.

We now have an outstanding opportunity to create antibodies against a host of diseases, James said. This discovery has great clinical potential.


'/>"/>

Contact: Adam Cohen
adam-cohen@omrf.org
405-271-7159
Oklahoma Medical Research Foundation
Source:Eurekalert

Related biology technology :

1. FDA Clears First Medical Product Made From Yulex(R) Natural Rubber
2. AGI Dermatics Clinical Data Identifies L-Ergothioneine as Part of Skins Natural Antioxidant System
3. Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief
4. Human Pheromone Sciences Enters Into Agreement to Reposition and Promote its Natural Attraction(R) Brand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... and READING, England , May ... http://www.indegene.com ), a leading global provider of clinical, ... and healthcare organisations and TranScrip ( http://www.transcrip-partners.com ), ... throughout the product lifecycle, today announced the extension ... IntraScience.      (Logo: http://photos.prnewswire.com/prnh/20141208/720248 ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... cuvettes are used in leading laboratories all over the globe. Their cute firefly ... addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never require ...
(Date:5/25/2016)... ... May 25, 2016 , ... The ... by the Office of the National Coordinator for Health IT (ONC) outlining a ... clinically relevant data were available when and where it was needed. The organization ...
(Date:5/24/2016)... ... May 24, 2016 , ... Cell therapies ... will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded a ... and tissue regeneration. , The novel method, developed by WPI faculty members Raymond ...
Breaking Biology Technology:
(Date:3/22/2016)... , PROVO and ... Newborn Screening Ontario (NSO), which operates the highest sample ... molecular testing, and Tute Genomics and UNIConnect, leaders in ... respectively, today announced the launch of a project to ... (NGS) testing panel. NSO has been ...
(Date:3/15/2016)... 2016 Yissum Research Development Company of ... of the Hebrew University, announced today the formation of ... of various human biological indicators. Neteera Technologies has completed ... private investors. ... of electromagnetic emissions from sweat ducts, enables reliable and ...
(Date:3/10/2016)... 2016 --> ... "Identity and Access Management Market by Component (Provisioning, Directory ... by Organization Size, by Deployment, by Vertical, and by ... The market is estimated to grow from USD 7.20 ... at a Compound Annual Growth Rate (CAGR) of 12.2% ...
Breaking Biology News(10 mins):