Navigation Links
The closest look ever at native human tissue
Date:12/5/2007

Seeing proteins in their natural environment and interactions inside cells has been a long-standing goal. Using an advanced microscopy technique called cryo-electron tomography, researchers from the European Molecular Biology Laboratory [EMBL] have visualised proteins responsible for cell-cell contacts for the first time. In this weeks issue of Nature they publish the first 3D image of human skin at molecular resolution and reveal the molecular Velcro-like organisation that interlinks cells.

This is a real breakthrough in two respects, says Achilleas Frangakis, group leader at EMBL. Never before has it been possible to look in three dimensions at a tissue so close to its native state at such a high resolution. We can now see details at the scale of a few millionths of a millimetre. In this way we have gained a new view on the interactions of molecules that underlie cell adhesion in tissues a mechanism that has been disputed over decades.

So far, the only information available about a proteins position and interactions in a cell was based on either light microscopy images at poor resolution or techniques that remove proteins from their natural context. Frangakis and his group have been developing a technique called cryo-electron tomography, with which a cell or tissue is instantly frozen in its natural state and then examined with an electron micro-scope. Electron microscopy normally requires tissue to be treated with chemicals or coated in metal, a procedure that disturbs the natural state of a sample. With cyro-electron tomography, images are taken of the untreated sample from different directions and assembled into an accurate 3D image by a computer.

The researchers applied this technique to observe proteins that are crucial for the integrity of tissues and organs like the skin and the heart, but also play an important role in cell proliferation. These proteins, called cadherins, are anchored in cell membranes and interact w
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
0049-622-138-7452
European Molecular Biology Laboratory  
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Viragen Internationals Subsidiary, ViraNative AB, Files to Seek Bankruptcy Protection in Sweden
2. Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers
3. Expiry of Hart-Scott-Rodino Waiting Period for JUVISTA(R) (Human TGF BETA 3)
4. New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human
5. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
6. Human Genome Sciences Announces $40 Million Milestone Payment Related to Albuferon(R) Development
7. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
8. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Thomas Weisel Partners Conference
9. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at BioCentury-Thomson Financial Investment Conference
10. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Bear Stearns Conference
11. Human Pheromone Sciences Enters Into Agreement to Reposition and Promote its Natural Attraction(R) Brand
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The closest look ever at native human tissue
(Date:8/28/2014)... (PRWEB) August 28, 2014 “This kit has ... to screen from 0 to 150 ppb,” said Mark Tess, ... a significant benefit to plant owners and USDA-GIPSA inspection agencies ... other commodities. Testing can take place in a matter of ... can the plant test the feed and grain before accepting ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... Whitehouse Laboratories is excited to announce that ... PTI Inspection Systems that will enable it to ... leak testing method development and validation programs using the ... part of this agreement, Whitehouse Labs has taken delivery ... developed and manufactured by PTI. The HVLD (high ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... 2011 ReportsnReports   ... & Recovery Solutions, Electric Vehicle, Telemedicine, NFC PoS Terminal, ... store Technoavio / Infiniti Research has ... geographies. Priced differently based on the market and geography ...
... a new way to develop straight carbon nanofibers on a ... in novel biomedical research tools, solar cells, water repellent coatings ... relies on ions to ensure the nanofibers are straight, rather ... the first time, that I know of, where someone has ...
... Elsevier, a world-leading provider of scientific, technical ... National University of Singapore (NUS), a leading global ... SgCodeJam24. This "Hackathon", a 24-hour programming competition, encourages ... advance the search and discovery process of scientific ...
Cached Biology Technology:ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 2ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 3ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 4ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 5Ions control shape of nanofibers grown on clear substrate 2Ions control shape of nanofibers grown on clear substrate 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 2Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 4Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 5
(Date:8/27/2014)... 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced ... offering of units of common stock and warrants at ... of $20 million, prior to deducting underwriting discounts and ... shares and warrants are immediately separable and will be ... the offering consists of 2,000 shares of common stock ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Law Enforcement ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html About Biometrics ... individuals on the basis of their physical or ... of both physiological traits such as fingerprints, face ...
(Date:8/27/2014)... cells to rearrange existing patterns of activity than when ... study of monkeys has found. The scientists explored the ... of brain cell networks. The study was partly funded ... into the brain and may have seen why it,s ... Batista, Ph.D., an assistant professor at the University of ...
Breaking Biology News(10 mins):WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Scientists plug into a learning brain 2Scientists plug into a learning brain 3
... University have determined that the buildup of sticky mucus found ... epithelial cell's ability to secrete fluid. This research appears ... issue of the Journal of Biological Chemistry, an American Society ... the most common, fatal genetic disease in the United States. ...
... of the materials that make up our bodies, nothing is ... structural protein in the body, reinforcing connective tissue, bones and ... forms sheets of tissue that support the skin and every ... that does not depend in some way on collagen. , ...
... Weizmann Institute of Science, led by Prof. Michal Schwartz ... findings that may have implications in delaying and slowing ... these developments is Schwartz's team's observations, published today in ... contribute to maintaining the brain's ability to maintain cognitive ...
Cached Biology News:Scientists discover basic defect in cystic fibrosis airway glands 2Wisconsin scientists find a way to make human collagen in the lab 2Wisconsin scientists find a way to make human collagen in the lab 3Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal 2Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal 3
... This product is designed to deparaffinize and ... formalin fixed paraffin-embedded tissue sections mounted on ... melting the paraffin at the high temperature ... with emulsification of the paraffin by detergent. ...
Chicken polyclonal to ytzF ( Abpromise for all tested applications). Antigen: Full length protein...
NEWBORN CALF SERUM AND PLASMA...
...
Biology Products: