Navigation Links
The birth of new cardiac cells
Date:12/5/2012

Boston, MA Recent research has shown that there are new cells that develop in the heart, but how these cardiac cells are born and how frequently they are generated remains unclear. In new research from Brigham and Women's Hospital (BWH), researchers use a novel method to identify these new heart cells and describe their origins.

This research is published in Nature on December 5, 2012.

A sophisticated imaging system (MIMS) demonstrates cell division in the adult mammalian heart.

"The question about how often cardiac cells are born has been extremely difficult to answer because there was a need for new techniques to help us understand this process. We are especially excited about our findings because of the novel way in which were able to show new heart cells, using Multi-isotope Imaging Mass Spectrometry (MIMS). Our collaborator, Claude Lechene, MD, had developed this technology, and as a team we harnessed this for the cardiac regeneration question." said Richard T. Lee, MD, a physician and researcher in the Cardiovascular Division at BWH and senior author of the paper. "These data present one piece of the puzzle when it comes to the discussion around the generation of new cardiac cells."

The team of BWH researchers marked existing cardiac cells genetically to cause them to express a green fluorescent protein. Then they used Multi-isotope Imaging Mass Spectrometry (MIMS) to examine the development of new heart muscle cells, called cardiomyocytes, in a pre clinical model over a period of months. Researchers were surprised to find that new heart muscle cells primarily arose from existing heart muscle cells, rather than stem cells. Even in the setting of a heart attack, when stem cells are thought to be activated, most new heart cells were born from pre-existing heart cells.

"Our data show that adult cardiomyocytes are primarily responsible for the generation of new cardiomyocytes and that as we age, we lose some capacity to form new heart cells," said Dr. Lee. "This means that we are losing our potential to rebuild the heart in the latter half of life, just when most heart disease hits us. If we can unravel why this occurs, we may be able to unleash some heart regeneration potential."
'/>"/>

Contact: Lori J. Schroth
ljschroth@partners.org
617-534-1604
Brigham and Women's Hospital
Source:Eurekalert

Related biology technology :

1. FDA Advisory Committee Declines to Recommend Approval of Progesterone Vaginal Gel 8% for the Reduction of Risk of Preterm Birth in Women with Short Uterine Cervical Length
2. Are people with HIV/AIDS more prone to sudden cardiac death?
3. Are people with HIV/AIDS more prone to sudden cardiac death?
4. Hong Kong Department of Health to Combat Sudden Cardiac Arrest With Powerheart AEDs
5. On the hunt for rare cancer cells
6. Scientists demonstrate high-efficiency quantum dot solar cells
7. National Press Club Celebration of the Publication of "The Grace of Stem Cells" by Jeong Chan Ra, Chairman of RNL BIO
8. Precision motion tracking - Thousands of cells at a time
9. Precision motion tracking Thousands of cells at a time
10. Neuralstem Cells Induce Significant Functional Improvement In Permanent Rat Spinal Cord Injury, Cell Study Reports
11. AllCells Introduces Autoimmune Diseased Cells and Tissue Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
Breaking Biology Technology:
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
Breaking Biology News(10 mins):