Navigation Links
The Medicines Patent Pool (MPP) Signs a Collaborative Agreement with the University of Liverpool to Develop HIV Nanomedicines
Date:11/30/2015

GENEVA, December 1, 2015 /PRNewswire/ --

Partnership includes an MPP licence for the university's Solid Drug Nanoparticle (SDN) Technology; Aims to support treatment scale-up through cost cuts of priority antiretrovirals (ARVs) 

The Medicines Patent Pool (MPP) today announced a collaboration with the University of Liverpool and a licence for the university's Solid Drug Nanoparticle (SDN) technology to accelerate the development of WHO-recommended antiretrovirals as nanomedicines. The agreement covers a territory of all 135 low- and middle-income countries and two high-income countries in Africa, where licensees based anywhere in the world will have the right to make, use and distribute lower cost ARVs based on SDN technology.

     (Logo: http://photos.prnewswire.com/prnh/20151026/280525LOGO)

"With the World Health Organization's "treat-all" recommendations, more than 20 million people are still in need of viable, sustainable treatment options," said Greg Perry, Executive Director of the MPP. "This partnership seeks to help meet new international HIV scale-up targets through the delivery of better-adapted low-dose medicines at a significant price reduction."

"We are thrilled the MPP has joined us to develop medicines based on SDN technology and to ensure that once developed, they will reach people who need them the most in developing countries," said the University of Liverpool's Vice Chancellor Janet Beer.

The University of Liverpool is one of the UK's leading research institutions with global leadership in the field of HIV and nanotechnology. Their nanotechnology programme aims to overcome some of the challenges of antiretroviral treatment today, including poor solubility and the need to administer large doses to ensure that enough of the drug is absorbed into the body to be effective. With an initial grant from the Research Council UK, University of Liverpool researchers have reformulated two HIV medicines to date and expect to conduct human trials of some of the first oral HIV nanomedicines this month. Currently, there are no HIV nanomedicines on the market.

Professor Andrew Owen from the University's Department of Pharmacology said, "dose reduction can lead to easier administration and potentially fewer side effects for people living with HIV. Smaller oral pills also facilitate lower production costs of active pharmaceutical ingredients which could slash treatment bills and allow health ministries to provide treatment to more people." Professor Steve Rannard from the University's Department of Chemistry added, "the university is proud of its interdisciplinary work in this area, which is a triumph of cross-faculty collaborative research."

Under the terms of the agreement, the University of Liverpool will develop nanoparticles of ARVs licensed to the MPP such as atazanavir, darunavir and lopinavir to improve their solubility and thus reduce dosage. The MPP and the University of Liverpool will engage with pharmaceutical partners for product development and industrial scale-up. The MPP will then sub-license the nano-formulated ARVs and facilitate competitive manufacturing to spur wide distribution of the new medicines in low- and middle-income countries.

"This collaboration marries the best of two leaders in the HIV medicines space - MPP with its tremendous record in licensing priority ARVs for adults and children of all ages and the University of Liverpool with the technology to revolutionise the way these ARVs are delivered," said Philippe Douste-Blazy, Chair of the Executive Board at UNITAID. "We are proud to back the MPP-University of Liverpool initiative."

About the University of Liverpool's Solid Drug Nanoparticle (SDN) Technology Programme  

Nanotechnology involves the reduction of matter to the scale of a billionth of a meter (1/800 of a human hair) and is widely used in fields such as electronics, cosmetics and energy. Nanomedicines have been approved for the treatment of cancers, hepatitis and other disease areas, but the application is relatively new to the area of HIV. The university's SDN technology allows the reformulation of poorly soluble and insoluble drugs into water dispersible formulations and can improve the delivery of drugs into the body.  This improved bioavailability allows reductions in the drug dosage and enables those drugs previously unsuitable for oral delivery to become orally bioavailable with therapeutically relevant pharmacokinetics.

About the Medicines Patent Pool 

The Medicines Patent Pool is a United Nations-back public health organisation working to increase access to HIV, viral hepatitis C and tuberculosis treatments in low- and middle-income countries. Through its innovative business model, the MPP partners with industry, civil society, international organisations, patient groups and other stakeholders to prioritise, forecast and license needed medicines and pool intellectual property to encourage generic manufacture and the development of new formulations. To date, the MPP has signed agreements with six patent holders for twelve HIV antiretrovirals and for one hepatitis C direct-acting antiviral. Its generic partners have distributed more than three billion doses of low-cost medicines to 117 countries. The MPP was founded and remains fully funded by UNITAID.



'/>"/>
SOURCE Medicines Patent Pool
Copyright©2015 PR Newswire.
All rights reserved


Related biology technology :

1. Clearing up inflammation with pro-resolving nanomedicines
2. Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets
3. Freeslate Collaborates with Medicines for Malaria Venture to Advance Therapeutic for Treating Malaria
4. Todays Research: Life Technologies, Opko Health, Medicines, and DaVita
5. Former Head of UK Medicines & Healthcare Products Regulatory Agency (MHRA) Sir Alasdair Breckenridge Joins NDA Partners
6. H3 Biomedicine and Selvita Announce Strategic Collaboration to Develop Precision Cancer Medicines
7. Fujitsu and ACRES Ally to Enhance Safety and Accelerate Medicines Development
8. Neumedicines Receives Award of $14 Million from BARDA for Continued Development of HemaMax™ as a Medical Countermeasure to Acute Radiation Exposure
9. Local Volunteers Play Valuable Role in Developing New Medicines in Croydon
10. Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd
11. Rx&D responds to PMPRB report: overall impact of medicines must always be considered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/16/2017)... Feb. 16, 2017  Rhythm, a biopharmaceutical ... deficiencies that result in life-threatening metabolic disorders, ... million mezzanine round of financing with existing ... Capital, New Enterprise Associates, Pfizer Venture Investments, ... healthcare investment fund. Rhythm will use the ...
(Date:2/16/2017)... ... February 16, 2017 , ... ... extended its industry leading Biochemistry Services specifically targeting the rapidly growing needs ... methods for the biochemical and biosimilar characterization , product-related impurity characterization, ...
(Date:2/15/2017)... ... February 15, 2017 , ... Park Systems , a leader in Atomic ... software that drastically boosts productivity with single click reliable nanoscale images, is now available ... setting up and taking the image once done manually by the operator producing high ...
(Date:2/15/2017)...  NASA provider SpaceX is scheduled to launch its ... Station  no earlier than 10:01 a.m. EST Saturday, Feb. ... 8:30 a.m. on NASA Television and the agency,s website. ... lift off on the company,s Falcon 9 rocket from ... Center in Florida , ...
Breaking Biology Technology:
(Date:2/2/2017)... Feb. 1, 2017  Central to its deep ... advances worldwide, The Japan Prize Foundation today announced ... have pushed the envelope in their respective fields ... Three scientists are being recognized with the 2017 ... not only contribute to the advancement of science ...
(Date:1/31/2017)... , Jan. 31, 2017  Spero Therapeutics, LLC, ... for the treatment of bacterial infections, today announced ... antibacterial candidates from Pro Bono Bio Ltd (PBB) ... of multi-drug resistant forms of Gram-negative bacteria.   The ... Infectives Ltd, a PBB group company. ...
(Date:1/26/2017)...  Crossmatch, a leading provider of security and identity ... combatting fraud, waste and abuse in assistance operations around ... on Disaster Relief conference in Panama City ... and foreign assistance organizations throughout Latin America ... a largely unacknowledged problem in the foreign assistance and ...
Breaking Biology News(10 mins):