Navigation Links
The Last Checkpoint to T Cell Fate
Date:7/1/2010

A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. Reported in Science this week, the discovery lends support to a new model for the development of blood cells lineages.

(PRWeb UK) July 1, 2010 -- A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. Reported in Science this week, the discovery lends support to a new model for the development of blood cells lineages.

While varying widely in function, all blood cells share a common origin in progenitors known as hematopoietic stem cells (HSC). In textbook theory, HSCs branch early on into two progenitor cell types, one of which, known as the common lymphoid progenitor (CLP), later differentiates into T and B cells. According to this model, T and B cells lose the potential to develop into non-lymphocytes (myeloid cells) once they pass the CLP branching point.

In a model put forth nearly ten years ago, the researchers proposed a radically different picture in which progenitor cells retain the potential to generate myeloid cells across all branches of development. In the current research, the researchers sought to substantiate this theory by pinpointing the moment at which T cell progenitors lose the potential to develop into myeloid cells, a key step in determining cell fate.

In experiments with mouse HSCs cultured on immobilized delta-like 4 proteins, the researchers found that progenitors developing toward T cells were arrested in the absence of so-called feeder cells, which support survival and growth. The arrested cells then entered a cycle of self-renewal in which they replicated but did not further develop. Testing of various conditions revealed that reduction of the cytokine interleukin-7 (IL-7), possibly corresponding to an environmental signal in the thymus, triggered resumption of development and differentiation into T cells.

Placing the final piece in the puzzle, the researchers discovered that T cell progenitors in the thymus from mice deficient in the gene Bcl11b exhibited the same halted development and self-renewal cycle, while further experiments connected up-regulation of the transcription factor encoded by this gene to IL-7 levels. Together, the findings identify Bcl11b as a “master gene” governing the final step toward differentiation into T cells, confirming the proposed model and heralding a paradigm shift in our understanding of blood cell lineages.

For more information, please contact:

Dr. Hiroshi Kawamoto
Laboratory for Lymphocyte Development
RIKEN Research Center for Allergy and Immunology (RCAI)
Tel: +81-(0)45-503-7010 / Fax: +81-(0)45-503-7009

Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-462-4715

###

Read the full story at http://www.prweb.com/releases/2010/07/prweb4217914.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The Last Checkpoint to T Cell Fate
(Date:8/16/2017)... 16, 2017  This year,s edition of the Inc. 5000 features a ... workforce solutions, has made the list for the third year in a ... fastest-growing private companies based on a set of quantitative metrics. In addition, ... fastest-growing companies in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... PA (PRWEB) , ... August 15, 2017 , ... ... one of the largest Asian exhibitions for analytical and scientific instruments. This year’s ... will be “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation ...
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its ... new website makes it easy to navigate through the site whether you’re in ... detailed product information, educational industry content and visit the company’s social media accounts, ...
(Date:8/11/2017)... ... , ... A staple in the community for more than 60 years, Bill ... including a new digital marketing strategy and updated logo. , As part of the ... with the South Texas Blood & Tissue Center for the month of August. ...
Breaking Biology Technology:
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):