Navigation Links
The BioProcess International October Issue - Now Available in Print, Digital and Mobile App Editions
Date:10/31/2013

ent.

Challenging Protein A

Financial opportunities are driving many technology developers to try replacing protein A, but users are growing less motivated to implement alternatives that offer only incremental improvements. For an alternative technology to seriously challenge protein A’s dominance in the antibody-purification market, simple replacement will not be enough. As Pete Gagnon describes, it will need to offer a true paradigm shift. And a few such candidates are now emerging.

New Approaches to Process Validation

The new process validation guidance asks companies in the United States and Europe to adopt life-cycle approaches — beyond the traditional three-to-five lots run at the center point of proposed ranges for operating parameters. In this article, a consensus paper from the January 2013 CMC Strategy Forum addresses how companies can leverage product design and process development information to facilitate adapting the Quality by Design paradigm more closely — allowing for a science- and risk-based selection of critical process parameters, key process indicators, and appropriate specification criteria.

Also published this month as part of the BioProcess International Supplement Series - Vaccines: New Tools and Technologies for an Expanding Industry

Also Available Online-only in the BPI Extra section of BioProcessintl.com:

Ask the Expert: The Future of Protein A

BPI’s managing editor Maribel Rios talked with Karol Lacki (staff scientist at GE Healthcare Biosciences) about the use and future of protein A in bioprocessing. Its selectivity, robustness, and well-known ability to bind to a wide range of IgG molecules have made protein A a widely accepted affinity resin for current purification streams. Nonetheless, the industry has raised some concerns over cost, productivity, and other issues. That has led to the development of novel alternatives for purification that reportedly offer advantages o
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA
2. BioProcess International March 2013 Issue Published on the App Store Featuring App-only Exclusive Content
3. Life Technologies Acquires BAC BV, Expands Capabilities in Bioprocessing
4. BioProcess International December 2012 Issue Now Available on the App Store for iPad and iPhone
5. BioStorage Technologies Expands its Service Offering to Include Advanced Bioprocessing Solutions
6. Russias International Biotechnology Center Generium Signs Access Agreement to Elseviers ScienceDirect and Embase
7. BioTechniques: The International Journal of Life Science Methods Announces the Publication of the October 2013 Digital Edition Now Available Online and in the App Store
8. PAREXEL International Reports First Quarter Fiscal Year 2014 Results
9. CA BOTANA International New Peptide Formulations
10. The Zacks Analyst Blog Highlights: Eaton, Baxter International, Bio-Rad Laboratories, INSYS Therapeutics and Boston Scientific
11. Dr. Rongxiang Xu wird während seiner Auszeichnung mit dem internationalen Golden Biatec 2013 erklären, wie sich menschliche Organe selbst regenerieren können
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... 2014 Reportbuyer.com has added a new ... - A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds ... microelectronics to water treatment, but is graphene the ... the Graphene Opportunity Report, authored by Tim ...
(Date:8/27/2014)... 27, 2014 Research and Markets  has ... Ratio Mass Spectrometer Industry Report 2014" report to ... Ratio Mass Spectrometer Industry Report 2014 is a professional ... global isotope ratio mass spectrometer industry. The ... definitions, classifications, applications and industry chain structure. The isotope ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Riviera ... is announcing the creation of the Sancilio Scientific ... take the SCI’s philosophy of looking to nature ... and development actions are based on sound scientific ... Scientific Advisory Board provides a vehicle for SCI ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... a network of tiny sensors as small as dewdrops ... intruder. Scattered outdoors on rocks, fence posts and doorways, ... are a completely new and cost-effective system for safeguarding and ... his Tel Aviv University Faculty of Engineering team drew upon ...
... in key leadership expertise to strengthen its European business ... SIRO ClinPharm Pvt. Ltd., a leading multinational full ... of Scott L. Spector as President Strategic Operations Europe. ... office of Omega Mediation . Mr. Spector brings ...
... faced H1N1 Flu OutbreaksJAMAICA, N.Y., May 26 ... of SANYO North America, announces the donation of ... level of safe, healthy air for areas where ... The first recipients to receive the donated SANYO ...
Cached Biology Technology:Intruder alert: Tel Aviv University's 'Smart Dew' will find you! 2SIRO Group Appoints Scott L. Spector as President, Strategic Operations, for its European Business 2SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools 2SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools 3SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools 4
(Date:8/27/2014)... German . , ... disease affecting the peripheral nervous system. Researchers from the ... Experimental Medicine and University Medical Centre Gttingen have discovered ... rats with the disease. These cells enwrap the nerve ... facilitates the rapid transfer of electrical impulses. If Schwann ...
(Date:8/27/2014)... willing to pay a premium for fruits, vegetables and ... the label claims is another matter. Now scientists studying ... to make sure farms are labelling their produce appropriately. ... Agricultural and Food Chemistry , could help prevent organic ... Food Safety Authority and the Wuerzburg University note that ...
(Date:8/27/2014)... NY (June, 2014) Outstanding basic research, a ... a dedication to patient care have earned the ... University Medical Center (CUMC) and NewYork-Presbyterian Hospital an ... the National Cancer Institute (NCI). The grant renews ... NCI-designated Comprehensive Cancer Centers in New York City ...
Breaking Biology News(10 mins):Potential therapy for incurable Charcot-Marie-Tooth disease 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... 25-year non-stop research expeditioninto the deep ocean. Over the ... are completing the installation off the British Columbia coast of ... observatory. Using three ships and at least one ROV, ... 400 instruments and sensors to the seafloor where they are ...
... Van Andel Research Institute (VARI) investigators ... therapeutic target in the treatment of the most aggressive ... have few treatment options. "Breast cancer mortality rates ... to traditional treatments tend to be more aggressive and ...
... For the first time, an international group of researchers ... of DNA on chromosome 6. This is the ... The LSUHSC research team was led by Nancy Buccola, APRN, ... Sciences Center New Orleans, who also coordinated the ten clinical ...
Cached Biology News:World's largest ocean observatory takes shape 2World's largest ocean observatory takes shape 3Possible drug target found for one of the most aggressive breast cancers 2LSUHSC research helps link schizophrenia to specific DNA region 2
... Best: DASGIPs Process Control integrates Process ... comprehensive documentation for cultivation processes. A ... pH, dissolved oxygen, temperature and agitation ... Profiles, e.g. constant or scheduled media ...
... LC Sciences provides a genome-wide microRNA ... and proprietary probe design, which enable highly ... (1-3). We have standard arrays for mature ... latest version of the Sanger miRBase database ...
... synthetic peptide whose sequences are derived from mouse resistin protein. ... - S - M - P - L - C - ... - D - K - K - I - K - ... used for neutralization and control experiments with the polyclonal antibody that ...
... Imaging System, Basic Package Superior Protein ... Range: The ProXPRESS 2D Proteomic Imaging System ... for both proteomic and general life science ... enabling the use of all dyes in ...
Biology Products: