Navigation Links
Texas A&M veterinary researchers achieve cloning first
Date:6/15/2010

COLLEGE STATION, June 11, 2010 Researchers at Texas A&M University College of Veterinary Medicine & Biomedical Sciences have achieved another cloning first with the successful delivery of a foal using oocytes from a live mare, the first such clone in the world. The delivery of the foal highlights Texas A&M's long tradition of leading science in equine reproduction, and has been a great experience for the owner of the new foal.

"I've always liked having three horses to ride," said Kit Knotts, proud owner of Mouse, the foal that represents the successful cloning efforts and the latest in equine reproduction science at Texas A&M University College of Veterinary Medicine & Biomedical Sciences. "I called and emailed breeders to spread the word that I was looking. Everything I could turn up was too small, too young, too old, not quite sound, etc. I realized I didn't want just another horse to have another body in the barn, I wanted another Marc."

Knotts' efforts to find a horse that had the same qualities as her prized Lippizan stallion, Marc, (Pluto III Marcella) would lead her to Texas A&M University and equine reproduction expert, Dr. Katrin Hinrichs. "My local veterinarian, Dr. Brad Newman, mentioned that Texas A&M was cloning, but it was when Dr. Adam Eichelberger joined Newman Equine that we began to pursue the possibilities."

Dr. Hinrichs' lab is noted for achieving the first cloned foal in North America, and the third in the world with Paris Texas, who arrived in 2005. The lab has since produced twelve cloned foals. Currently there are only three labs in the world that have reported the successful birth of cloned horses Texas A&M University, Viagen (a commercial venture based in Texas), and the lab of Dr. Cesare Galli, in Italy.

"We have worked on this clone for about two years," said Hinrichs, a professor in the Department of Veterinary Physiology & Pharmacology. "This is actually our first foal produced using oocytes, or egg cells, from live mares. We recovered the oocytes from our herd of research mares using the same method used to recover eggs from women for in vitro fertilization. We used the oocytes for the cloning process, which made it difficult as we had very few to work with at any one time. During the cloning process, we tested a new technique that has been reported in mice to decrease birthing problems. Mrs. Knotts has been very supportive of our efforts to clone her horse, and has even named the foal 'Mouse' in honor of the research that produced him."

The process began with a biopsy of skin cells from Marc, the horse to be cloned. Through the cloning process using oocytes recovered from a live mare, viable embryos were developed and sent to Hartman Equine Reproduction Center, an embryo transfer facility in North Texas which works closely with Hinrichs' lab, for transfer into surrogate mares. Minnie, the mare carrying Mouse, stayed in North Texas for approximately 200 days, then was sent to her new home in Florida.

Minnie began to show signs of an early delivery, and was taken to the University of Florida College of Veterinary Medicine for observation and intervention. That's where Mouse arrived and was cared for by a team of neonatal experts that helped make sure he would make it through this critical time.

"Having Minnie with us for several months prior to foaling has been great," added Knotts. "The teamwork between Dr. Hinrichs and her colleagues at the University of Florida has been outstanding, frankly saving Mouse's life more than once before and after birth.

Hinrichs noted that while Mouse is truly an identical twin to the original horse, Marc, that there will be differences as the foal grows due to environmental influences.

"I have become really interested in the science involved," notes Knotts. "Dr. Hinrichs has been wonderful about keeping me up on what is going on in the lab and feeds my interest by explaining things in terms I can largely understand. I am very proud of the contributions our project has made to the body of knowledge about cloning, which benefits far more areas of equine reproduction than most realize."


'/>"/>

Contact: Katrin Hinrichs
khinrichs@cvm.tamu.edu
Texas A&M University
Source:Eurekalert

Related biology technology :

1. Texas Boy Receives Wheelchair From New Hampshire Couples Recently Deceased Granddaughter
2. For creating new field of science, Texas chemist wins international prize
3. Blue Cross and Blue Shield of Texas Launches an Integrated Medical-Dental Health Program
4. Texas Oncology-Baylor Sammons Cancer Center Recognized for Highest Commitment to Clinical Research at ASCO
5. LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences
6. Annual List of Best Doctors in Dallas Showcases Texas Institute for Surgery Physicians
7. Study From the University of Texas M.D. Anderson Cancer Center Demonstrates That AHCC(R) is Safe in Combination With Most Chemotherapeutic Agents
8. SpineSmith Partners Collaborates with University of Texas Biomedical Engineering Students to Develop Innovative Products
9. Self-powered devices possible, says Texas A&M researcher
10. NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas
11. Panda Ethanols Hereford, Texas Subsidiary Files Voluntary Chapter 11
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... , ... January 11, 2017 , ... ... scientific grants to ground-breaking microbiome studies. Its most recent microbiome impact grant award ... who will study the effect of long-term use of oral antibiotics, prescribed for ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... make all the difference when navigating the challenges young businesses face. With the ... the extensive expertise and experience of Geoff DiMasi, Founder and Principal of interactive ...
(Date:1/11/2017)... ... January 11, 2017 , ... Back pain relief technology is now available ... Surgery for positive back pain relief for WAR members. , This spinal restoration platform ... be life changing for millions suffering from chronic back pain. , What A ...
(Date:1/11/2017)... and BENGALURU, India , Jan. ... Biocon Ltd. (BSE code: 532523, NSE: BIOCON) today announced ... accepted Mylan,s biologics license application (BLA) for MYL-1401O, a ... This product is a proposed biosimilar to branded trastuzumab, ... The anticipated FDA goal date set under the Biosimilar ...
Breaking Biology Technology:
(Date:12/15/2016)... Dec 15, 2016 ... Research and Markets has announced the addition of ... The report forecasts the global military biometrics market to ... The report has been prepared based on an in-depth market analysis ... its growth prospects over the coming years. The report also includes a ...
(Date:12/15/2016)... "Increase in mobile transactions is driving the ... market is expected to grow from USD 4.03 billion ... a CAGR of 29.3% between 2016 and 2022. The ... demand for smart devices, government initiatives, and increasing penetration ... is expected to grow at a high rate during ...
(Date:12/8/2016)... 2016  Singulex, Inc., the leader in Next Generation ... a license and supply agreement with Thermo Fisher Scientific, ... Singulex access to Thermo Scientific BRAHMS PCT (Procalcitonin), a ... used to diagnose systemic bacterial infection and sepsis and ... aid in assessing the risk of critically ill patients ...
Breaking Biology News(10 mins):