Navigation Links
Texas A&M chemical engineer's work could lead to improved DNA analysis
Date:9/9/2010

, he says. Because the fragment wants to return to its coiled shape, it quickly squeezes through the smaller pore so that it can enter a larger pore where there is enough room for it to return to its natural shape.

Harnessing this entropic trapping effect for separation through a hydrogel marks a significant advancement in DNA studies, Ugaz says.

Although it has long been predicted that entropic trapping effects can potentially benefit a wide variety of applications including separation technologies, actually figuring out how to use this phenomenon previously has been difficult in hydrogels because it has not been clear how this transport mechanism is linked to the gel's porous structure, Ugaz explains.

In other words, hydrogels need to have very specific properties such as pore size distribution, and prior to these findings, there has been no way to know how to choose the right hydrogel that has the right properties, Ugaz notes.

"You want to be able to detect the smallest possible difference in size between DNA fragments," Ugaz explains. "The size of the fragments may be very close, and you may need to detect a difference of one unit in size. To do this, you would want to be able to specifically construct a hydrogel with the necessary pore structure to achieve this."

Ugaz's research provided the "instructions on how to do just that.

"We have a better picture of how to do this than what has existed," Ugaz says. "We know what the gel needs to look like and how it needs to be prepared.

"We're able to understand how to construct a gel that would allow DNA to move via an entropic trapping method that enhances separation performance and in turn leads to more effective analysis. This finding could have enormous implications by helping remove current barriers to separation efficiency"


'/>"/>

Contact: Ryan Garcia
ryan.garcia99@tamu.edu
979-845-9237
Texas A&M University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences
2. Annual List of Best Doctors in Dallas Showcases Texas Institute for Surgery Physicians
3. Study From the University of Texas M.D. Anderson Cancer Center Demonstrates That AHCC(R) is Safe in Combination With Most Chemotherapeutic Agents
4. SpineSmith Partners Collaborates with University of Texas Biomedical Engineering Students to Develop Innovative Products
5. Self-powered devices possible, says Texas A&M researcher
6. NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas
7. Panda Ethanols Hereford, Texas Subsidiary Files Voluntary Chapter 11
8. WaferGen Biosystems, ImmuneRegen BioSciences and University of Texas Southwestern Medical Center to Collaborate on Novel Wound Healing Research
9. Z Therapy Is The First In North Texas To Offer Revolutionary Treatment Option For Neck Pain Sufferers
10. Solar cells, geological storage research receive DOE funding at the University of Texas at Austin
11. Dozens of New Clean Technology and Nanotech Products Unveiled at TechConnect World Expo in Houston, Texas, May 5-6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... SoundConnect , an award winning ... to announce the addition of Adobe Connects Learning ... tools to quickly deploy and manage online courses ... for desktop and mobile learning solutions. , Adobe ... online training solution, enabling organizations to deploy, measure, ...
(Date:7/31/2014)... July 31, 2014 Sales Horizons, a ... its online sales training course – Mastering the ... sales performance. , Drawn from proven sales training programs ... Mastering the Complex Sale online sales training course is ... who has face-to-face contact with customers, like technical support, ...
(Date:7/30/2014)... 30, 2014 W. R. Grace ... of the REVELERIS® Prep purification system , ... chromatographers, and other researchers to perform both flash ... unit. , With the REVELERIS® Prep purification system, ... chromatography modes with a simple touch of the ...
(Date:7/30/2014)... -- The Chicago Bears are excited to announce the team,s ... an effort to raise awareness of skin cancer. Through ... me™ skin cancer screenings at a preseason fan event ... SPOT me™ is an educational campaign designed to inform the ... skin cancer, and encourages people to get screened by ...
Breaking Biology Technology:SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Grace Launches New REVELERIS® Prep Purification System 2Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 2Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 4
... American Stock Exchange(R),(Amex(R)) today listed the common ... symbol RNN., Rexahn Pharmaceuticals is a ... discover, develop and commercialize,innovative treatments for cancer, ... unmet medical needs. Rexahn,s compounds are designed,to ...
... Judges for Nikon Small World, MELVILLE, N.Y., ... received a record number of entries for the ... by over 300,images. The oldest and most respected ... world,s best photomicrographers who create beautiful,imagery while showing ...
... Informed Medical Communications,(IMC), a leading provider of peer-to-peer ... appointment of Bert,Marchio to the position of Executive ... ), Marchio brings to IMC over 20 ... both the public and private sectors, with the ...
Cached Biology Technology:American Stock Exchange Lists the Common Stock of Rexahn Pharmaceuticals, Inc. 2Nikon Instruments Receives Record Number of Entries for Nikon Small World 2Informed Medical Communications Appoints New Chief Financial Officer 2
(Date:7/30/2014)... that David L. Kaplan, Ph.D., will head the brand-new, ... as editor-in-chief. With the first issue slated for publication ... research in the rapidly burgeoning field of biomaterials, the ... with living or biological systems. , "This new journal ... the field of biomaterials over the past decade and ...
(Date:7/30/2014)... Sciences Institute (SALSI), a joint venture between The University ... of Texas Health Science Center at San Antonio, has ... The winners, Emily Boice from UTSA and Lei Huang ... their project titled, "Novel engineered ferritins for tracking and ... and Huang,s research is focused on finding a treatment ...
(Date:7/30/2014)... could be as simple as inserting a medicated, disappearing ... Washington bioengineers have discovered a potentially faster way to ... HIV. Their method spins the drug into silk-like fibers ... higher doses of the drug than possible with other ... could offer women a potentially more effective, discreet way ...
Breaking Biology News(10 mins):ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... of human growth hormone (GH) by healthy elderly people found ... body composition but not in body weight or other clinically ... increased rates of unhealthy side effects such as soft tissue ... breast development. They were also somewhat more likely to ...
... to produce useful proteins could be an inexpensive ... the Flanders Interuniversity Institute for Biotechnology (VIB) at ... seeds proteins that have a very strong resemblance ... antibody variants are just as active as the ...
... of Warwick reveals that a Nobel Prize brings more than ... two years to your life. , The research by Professor ... Matthew Rablen, (a former Warwick postgraduate researcher now a government ... and Immortality". , The researchers carried out their study ...
Cached Biology News:Growth hormone is not the anti-aging bullet for healthy adults 2Growth hormone is not the anti-aging bullet for healthy adults 3Producing medicines in plant seeds 2Producing medicines in plant seeds 3New research says winning a Nobel Prize adds nearly 2 years to your lifespan 2
... Proliferator-Activated Receptor-gamma (PPAR) is a member ... ligand-activated transcription factors that heterodimerize with ... involved in the regulation of glucose ... (TZD) class of anti-diabetic agents called ...
... The Vibratome Company has joined forces with ... the Vibratome 411301 Tissue Chopper. This tissue ... sections of tissue for metabolic experiments and ... irregular specimens available at biopsy or from ...
...
... a fluorescence scanner with 1 or 2 ... Protein, CGH, ) spotted on standard slides ... InnoScan700 scanners include three different models:, ... simultaneous dual fluorescence scanner (635nm and 532nm). ...
Biology Products: