Navigation Links
Texas A&M chemical engineer's work could lead to improved DNA analysis
Date:9/9/2010

, he says. Because the fragment wants to return to its coiled shape, it quickly squeezes through the smaller pore so that it can enter a larger pore where there is enough room for it to return to its natural shape.

Harnessing this entropic trapping effect for separation through a hydrogel marks a significant advancement in DNA studies, Ugaz says.

Although it has long been predicted that entropic trapping effects can potentially benefit a wide variety of applications including separation technologies, actually figuring out how to use this phenomenon previously has been difficult in hydrogels because it has not been clear how this transport mechanism is linked to the gel's porous structure, Ugaz explains.

In other words, hydrogels need to have very specific properties such as pore size distribution, and prior to these findings, there has been no way to know how to choose the right hydrogel that has the right properties, Ugaz notes.

"You want to be able to detect the smallest possible difference in size between DNA fragments," Ugaz explains. "The size of the fragments may be very close, and you may need to detect a difference of one unit in size. To do this, you would want to be able to specifically construct a hydrogel with the necessary pore structure to achieve this."

Ugaz's research provided the "instructions on how to do just that.

"We have a better picture of how to do this than what has existed," Ugaz says. "We know what the gel needs to look like and how it needs to be prepared.

"We're able to understand how to construct a gel that would allow DNA to move via an entropic trapping method that enhances separation performance and in turn leads to more effective analysis. This finding could have enormous implications by helping remove current barriers to separation efficiency"


'/>"/>

Contact: Ryan Garcia
ryan.garcia99@tamu.edu
979-845-9237
Texas A&M University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences
2. Annual List of Best Doctors in Dallas Showcases Texas Institute for Surgery Physicians
3. Study From the University of Texas M.D. Anderson Cancer Center Demonstrates That AHCC(R) is Safe in Combination With Most Chemotherapeutic Agents
4. SpineSmith Partners Collaborates with University of Texas Biomedical Engineering Students to Develop Innovative Products
5. Self-powered devices possible, says Texas A&M researcher
6. NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas
7. Panda Ethanols Hereford, Texas Subsidiary Files Voluntary Chapter 11
8. WaferGen Biosystems, ImmuneRegen BioSciences and University of Texas Southwestern Medical Center to Collaborate on Novel Wound Healing Research
9. Z Therapy Is The First In North Texas To Offer Revolutionary Treatment Option For Neck Pain Sufferers
10. Solar cells, geological storage research receive DOE funding at the University of Texas at Austin
11. Dozens of New Clean Technology and Nanotech Products Unveiled at TechConnect World Expo in Houston, Texas, May 5-6
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading ... reproductive medicine. In his new role as treasurer, ... board and will have a voice in furthering the ... supported ASRM since 1984 when he joined while conducting ...
(Date:12/24/2014)... CA (PRWEB) December 23, 2014 Pipette.com ... where their Twitter followers can submit their #HolidayInTheLab pictures ... and their lab mates. , For those struggling to ... mates, the Pipette.com Holiday in the Lab Contest provides ... Pipette.com Twitter followers to send pictures of their ...
(Date:12/24/2014)... 2014 Vermillion, Inc. (Nasdaq:   VRML), ... announced today that investors including Oracle Investment Management, ... and several Vermillion directors have agreed to purchase ... common stock and warrants to purchase unregistered shares ... Under the terms of the ...
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich Corporation ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements ... expired on December 22, 2014, thereby completing the ... for the acquisition of the Company by Merck ... clearance satisfies another condition to closing the transaction, ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3
... Germany and MINNEAPOLIS, Minnesota, February 11, Bayer HealthCare ... Minneapolis, MN, (Nasdaq: POSS ), announced today ... pursuant to which,MEDRAD will acquire Possis Medical in ... or a total equity value of approximately US-Dollar ...
... Feb. 11 Replikins Ltd. announced that the,quantitative ... structure,predicts that the current H5N1 cycle is over. ... and high mortality characteristics,are expected to subside - ... or,another influenza virus strain begins., 140,000 virus ...
... Cryo-Cell,International, Inc. (OTC Bulletin Board Symbol: CCEL) (the ... family cord blood banks, today,announced results for fiscal ... ended November 30, 2007 were,approximately $17.5 million, up ... ended November 30, 2006. The Company reported a ...
Cached Biology Technology:Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 2Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 3Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 4Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 5Bayer HealthCare Affiliate MEDRAD and Possis Medical Sign Definitive Merger Agreement 6FluForecast(R) Replikin Count(TM) Predicts That the H5N1 Cycle Which Began in 1996 Is Now Over 2Cryo-Cell International, Inc. Reports Results for Fiscal 2007 2Cryo-Cell International, Inc. Reports Results for Fiscal 2007 3Cryo-Cell International, Inc. Reports Results for Fiscal 2007 4Cryo-Cell International, Inc. Reports Results for Fiscal 2007 5Cryo-Cell International, Inc. Reports Results for Fiscal 2007 6
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
(Date:12/10/2014)... YORK , Dec. 8, 2014 You,ve been ... banking account but can,t remember your password, site key or ... Who was your first grade teacher? Today, ... the app that will finally put an end ... – 1U TM . 1U leverages a user,s ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... (December 4, 2013) Mating with more than one male ... increase in risks. This is according to a new ... by behavioral ecologist John Hoogland, Professor at the University ... Mating entails significant costs such as increased susceptibility to ...
... Biological Sciences (AIBS) has selected three individuals as winners ... Contest. This is the third year AIBS has ... for members of the scientific community to showcase for ... including informing natural resources management, addressing climate change, improving ...
... and relatives comprise the megadiverse insect order ... on Earth, far surpassing the number of known ... of animals (beetles, butterflies, wasps, and true flies) ... metamorphosis, i.e. having a dormant pupa, jointly known ...
Cached Biology News:Multiple mates worth the risk for female prairie dogs 2AIBS announces winners of Faces of Biology photo competition 2Fossils clarify the origins of wasps and their kin: alderfly ancestors, snakefly cousins 2
... centrifuge design and manufacturing, Thermo IEC introduces ... (refrigerated) general purpose models provide new conveniences ... Sample Preparation , The CL3 series will ... and has speed and accuracies to the ...
... Large (Klenow) Fragment, Exonuclease Minus, is a ... 5´→3´ and the 3´→5´ exonuclease activities present ... (1,2). It is used for random primer ... (5). Klenow Fragment, Exonuclease Minus, will leave ...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Biology Products: