Navigation Links
Tethered to chip, energy supply that drives sperm could power 'nanobot'
Date:12/3/2007

Washington, D.C. -- The biological pathway that powers sperm to swim long distances could be harnessed to nanotech devices, releasing drugs or performing mechanical functions inside the body, according to a presentation at the American Society for Cell Biologys 47th Annual meeting.

The work by researchers at Cornells Baker Institute of Animal Health may be the first demonstration of how multistep biological pathways can be assembled and function on a human-made device.

Mammalian sperm have to delivery energy to the long, thin, whip-like tails that power their swimming. Sperm meet the challenge, in part, by onsite power generation, modifying the enzymes of glycolysis so that they can attach themselves to a solid structure running the major length of the sperm tail. From that secure perch, glycolytic enzymes convert sugar into ATP, supplying energy all along the sperms bending and flexing tail.

Chinatsu Mukai, Alex Travis, and others at Cornells College of Veterinary Science looked at the early steps in the glycolysis pathway to see if they could move it from the thin fibrous sheath that covers the sperm tail to a solid inorganic substitutea nickel-NTA (nitrilotriacetic acid) chip.

First, the researchers replaced the sperm-specific targeting domain of hexokinase, the first enzyme of glycolysis, with a tag that binds to a special gold surface. Even when tethered, the enzyme remained functional. Next they tagged the second enzyme in the pathway, glucose-6-phosphate isomerase. This too was active when tethered. With both attached to the same support, the enzymes acted in series with the product of the first reaction serving as substrate for the second.

These are only the first steps in reproducing the full glycolytic pathway on an inorganic support, say Mukai and Travis. Mukai and Travis suggest that their work serves as proof of principle that the organization of the glycolytic pathway in sperm might provide a natu
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference
2. China Technology Announces Entry to the Solar Energy Sector
3. BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy
4. NanoLogix Inc. Announces Historical First in Energy Generation With Bioreactor-Produced Hydrogen at Welchs
5. Nanotech could make solar energy as easy and cheap as growing grass
6. International Atomic Energy Agency and National Foundation for Cancer Research Launch Major Initiative to Improve Cancer Prevention and Treatments in Developing Countries
7. Nanowire generates power by harvesting energy from the environment
8. Biomaxx Systems Inc. Renews Membership With Bioenergy Australia
9. BioEnergy International Facility Opens in Bay State
10. Bioenergy Life Science and Integrative Therapeutics, Inc. Form Exclusive Co-Marketing Alliance
11. BioFuel Energy Announces Earnings Release and Shareholder Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2015)... Houston, Texas (PRWEB) April 23, 2015 ... patient’s True Flow (blood flow through the device) in ... provided by Numerex, the world’s leading provider of Machine ... IoT. , True Flow via VADLink.com ... if there is any drop in flow below a ...
(Date:4/22/2015)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ) today reported ... For the first quarter ended March 31, 2015, ... or $0.08 per share, compared to a net loss ... same period in 2014. As of March 31, 2015, ... interest receivable of $226.1 million. Revenues for ...
(Date:4/22/2015)... 22, 2015 Today, DuPont announced ... a leading microbiome discovery company. This acquisition will ... access in both seed and crop protection to ... globally. , “In 2014, the businesses in ... segments sold more than $1 billion in biological ...
(Date:4/22/2015)... Over the last five years, ... growth primarily due to growth in the ... increased nanotechnology R&D expenditure and increased international ... http://www.marketsandmarkets.com/requestCustomization.asp?id=65048077 , In this report, the ... on the basis of products and applications. ...
Breaking Biology Technology:Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8DuPont Acquires Taxon Biosciences, Inc. 2DuPont Acquires Taxon Biosciences, Inc. 3DuPont Acquires Taxon Biosciences, Inc. 4Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 2Nanotechnology-based Medical Devices Market to Reach Around $8.5 billion by 2019 - Published by MarketsandMarkets 3
... API Software, Inc. announced today ... implement the majority of APIs suite of labor ... The solution will include Payrollmation time and attendance, ... human resources software. , ,The hospital is adopting ...
... Network Health Plan , Affinity Health Systems health plan ... today the availability of new online services for NHPs ... Internet-based health management system. , ,NHP will launch the ... member portals. Starting this summer, NHPs providers will be ...
... swing a golf club with one arm, or to write a ... would you? Or, at the very least, progress would be painfully ... human embryonic stem cells, the bodys core cells that can grow ... of embryonic stem cell research have turned out to be much ...
Cached Biology Technology:Lifting federal limits on stem cell research would speed search for cures 2Lifting federal limits on stem cell research would speed search for cures 3
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... a landscape susceptible to invasion by alien plant species, ... contributing to the accelerating spread of exotic aquatic species, ... issue of BioScience. John A. Havel of Southwest Missouri ... Vander Zanden of the University of Wisconsin survey evidence ...
... multiple complex biological interactions in a yeast cell in ... the networks of interaction by which components of a ... Open Access journal Journal of Biology shows that such ... predictions about interactions that haven't been observed experimentally. , ...
... just can't tell where you might find love these ... and a social psychologist found love-related neurophysiological systems inside ... responses in the brains of 17 young men and ... madly in love. , The multidisciplinary team found that ...
Cached Biology News:Reservoirs may accelerate the spread of invasive aquatic species, researchers say 2Navigating an integrated yeast network 2Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 2Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 3Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 4Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 5Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive 6
Rabbit polyclonal to GABA A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Rabbit polyclonal to VPAC2 ( Abpromise for all tested applications). entrezGeneID: 7434 SwissProtID: P41587...
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
Biology Products: