Navigation Links
Tethered to chip, energy supply that drives sperm could power 'nanobot'
Date:12/3/2007

Washington, D.C. -- The biological pathway that powers sperm to swim long distances could be harnessed to nanotech devices, releasing drugs or performing mechanical functions inside the body, according to a presentation at the American Society for Cell Biologys 47th Annual meeting.

The work by researchers at Cornells Baker Institute of Animal Health may be the first demonstration of how multistep biological pathways can be assembled and function on a human-made device.

Mammalian sperm have to delivery energy to the long, thin, whip-like tails that power their swimming. Sperm meet the challenge, in part, by onsite power generation, modifying the enzymes of glycolysis so that they can attach themselves to a solid structure running the major length of the sperm tail. From that secure perch, glycolytic enzymes convert sugar into ATP, supplying energy all along the sperms bending and flexing tail.

Chinatsu Mukai, Alex Travis, and others at Cornells College of Veterinary Science looked at the early steps in the glycolysis pathway to see if they could move it from the thin fibrous sheath that covers the sperm tail to a solid inorganic substitutea nickel-NTA (nitrilotriacetic acid) chip.

First, the researchers replaced the sperm-specific targeting domain of hexokinase, the first enzyme of glycolysis, with a tag that binds to a special gold surface. Even when tethered, the enzyme remained functional. Next they tagged the second enzyme in the pathway, glucose-6-phosphate isomerase. This too was active when tethered. With both attached to the same support, the enzymes acted in series with the product of the first reaction serving as substrate for the second.

These are only the first steps in reproducing the full glycolytic pathway on an inorganic support, say Mukai and Travis. Mukai and Travis suggest that their work serves as proof of principle that the organization of the glycolytic pathway in sperm might provide a natural engineering solution of how to produce ATP locally on nano devices.


'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Related biology technology :

1. Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference
2. China Technology Announces Entry to the Solar Energy Sector
3. BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy
4. NanoLogix Inc. Announces Historical First in Energy Generation With Bioreactor-Produced Hydrogen at Welchs
5. Nanotech could make solar energy as easy and cheap as growing grass
6. International Atomic Energy Agency and National Foundation for Cancer Research Launch Major Initiative to Improve Cancer Prevention and Treatments in Developing Countries
7. Nanowire generates power by harvesting energy from the environment
8. Biomaxx Systems Inc. Renews Membership With Bioenergy Australia
9. BioEnergy International Facility Opens in Bay State
10. Bioenergy Life Science and Integrative Therapeutics, Inc. Form Exclusive Co-Marketing Alliance
11. BioFuel Energy Announces Earnings Release and Shareholder Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the ... major shareholders, Clean Technology Fund I, LP and Clean ... based venture capital funds which together hold approximately ... fully diluted, as converted basis), that they have entered ... equity holdings in Biorem to TUS Holdings Co. Ltd. ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a range ... place between the two entities said Poloz. Speaking ... Ottawa , he pointed to the country,s inflation ... federal government. "In ... "Both institutions have common economic goals, why not sit down ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in clinical ... Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits ... tips, tools, and strategies for clinical researchers. , “The landscape of how patients ...
Breaking Biology Technology:
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):