Navigation Links
Tethered to chip, energy supply that drives sperm could power 'nanobot'
Date:12/3/2007

Washington, D.C. -- The biological pathway that powers sperm to swim long distances could be harnessed to nanotech devices, releasing drugs or performing mechanical functions inside the body, according to a presentation at the American Society for Cell Biologys 47th Annual meeting.

The work by researchers at Cornells Baker Institute of Animal Health may be the first demonstration of how multistep biological pathways can be assembled and function on a human-made device.

Mammalian sperm have to delivery energy to the long, thin, whip-like tails that power their swimming. Sperm meet the challenge, in part, by onsite power generation, modifying the enzymes of glycolysis so that they can attach themselves to a solid structure running the major length of the sperm tail. From that secure perch, glycolytic enzymes convert sugar into ATP, supplying energy all along the sperms bending and flexing tail.

Chinatsu Mukai, Alex Travis, and others at Cornells College of Veterinary Science looked at the early steps in the glycolysis pathway to see if they could move it from the thin fibrous sheath that covers the sperm tail to a solid inorganic substitutea nickel-NTA (nitrilotriacetic acid) chip.

First, the researchers replaced the sperm-specific targeting domain of hexokinase, the first enzyme of glycolysis, with a tag that binds to a special gold surface. Even when tethered, the enzyme remained functional. Next they tagged the second enzyme in the pathway, glucose-6-phosphate isomerase. This too was active when tethered. With both attached to the same support, the enzymes acted in series with the product of the first reaction serving as substrate for the second.

These are only the first steps in reproducing the full glycolytic pathway on an inorganic support, say Mukai and Travis. Mukai and Travis suggest that their work serves as proof of principle that the organization of the glycolytic pathway in sperm might provide a natural engineering solution of how to produce ATP locally on nano devices.


'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Related biology technology :

1. Verenium Corporation to Present at the Upcoming Cowen and Company Clean Energy Conference
2. China Technology Announces Entry to the Solar Energy Sector
3. BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy
4. NanoLogix Inc. Announces Historical First in Energy Generation With Bioreactor-Produced Hydrogen at Welchs
5. Nanotech could make solar energy as easy and cheap as growing grass
6. International Atomic Energy Agency and National Foundation for Cancer Research Launch Major Initiative to Improve Cancer Prevention and Treatments in Developing Countries
7. Nanowire generates power by harvesting energy from the environment
8. Biomaxx Systems Inc. Renews Membership With Bioenergy Australia
9. BioEnergy International Facility Opens in Bay State
10. Bioenergy Life Science and Integrative Therapeutics, Inc. Form Exclusive Co-Marketing Alliance
11. BioFuel Energy Announces Earnings Release and Shareholder Conference Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... Boston, MA (PRWEB) , ... January 17, 2017 ... ... of the completely re-engineered Drug Safety Technology Consortium™ (SafeTEC™), $3 million in investment ... be validating these new tools and assays, and their applicability in drug safety ...
(Date:1/17/2017)... 17, 2017  Protagonist Therapeutics, Inc. (NASDAQ: ... initiated a global Phase 2b induction study in ... targets alpha4beta7 integrin. The aim of this randomized, ... the safety/tolerability and efficacy of PTG-100 in approximately ... severe active disease. "We are ...
(Date:1/16/2017)...   Valentin A. Pavlov, PhD , associate investigator, ... CEO of The Feinstein Institute for Medical Research ... the nervous system regulates the immune system, which will ... devices to treat disease and injury. The analysis ... The paper examines various studies which further define ...
(Date:1/14/2017)... ... 14, 2017 , ... Seattle-based Phase Genomics has announced the ... researchers around the globe. Long considered a “holy grail” in biological research, ... of scientific questions. The announcement was made today at the Plant & ...
Breaking Biology Technology:
(Date:1/12/2017)... , Jan. 12, 2017  New research undertaken by ... of the future.  1,000 participants were simply asked which office ... which we may consider standard issue.  Insights on what ... were also gathered from futurists and industry leaders including ... James Canton .  Some of these ...
(Date:1/6/2017)... JOLLA, Calif. , Jan. 6, 2017 /PRNewswire/ ... 1 safety studies in healthy volunteers of a ... intended to treat acute pancreatitis. ... is typically a mild disorder, but can be ... organ failure and sepsis, where extended hospital stays, ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
Breaking Biology News(10 mins):