Navigation Links
Teriflunomide in Adjunct to Interferon Beta Significantly Improved Outcomes of Multiple Sclerosis Patients
Date:6/5/2010

PARIS, June 5, 2010 /PRNewswire-FirstCall/ --

- One-Year Phase II Data Presented at the 2010 ACTRIMS Meeting

Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) reported today new one-year data from a Phase II study with teriflunomide, a novel oral disease modifier being investigated for the treatment of relapsing multiple sclerosis (RMS). Study results demonstrated an improvement in outcomes, with a consistent safety profile with the data from a previous Phase II monotherapy study, in patients treated with interferon beta (IFN-[BETA]) - a standard therapy in RMS - and receiving teriflunomide 7mg or 14mg, compared with patients treated with IFN-[BETA] and receiving oral placebo.

The findings were the subject of the leading oral presentation at the American Committee for Treatment and Research in Multiple Sclerosis meeting (ACTRIMS) in San Antonio, TX, USA. This study is part of a comprehensive clinical development program for teriflunomide both in monotherapy and in adjunct therapy in MS patients.

Although this Phase II study (n=116) was not powered to test for efficacy, patients taking 7mg or 14mg teriflunomide in adjunct to stable dose IFN-[BETA] experienced a significant relative risk reduction (86%; p=0.0005 and 82.8%; p<0.0001 respectively) in the number of gadolinium enhancing T1 (T1-Gd) lesions on brain magnetic resonance imaging compared with patients taking stable dose IFN-[BETA] with placebo. No unexpected safety findings have been showed with teriflunomide during the one-year period of the study as compared to the initial six-month period. Discontinuations due to treatment-emergent adverse e
'/>"/>

SOURCE Sanofi-aventis
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. FDA Issues Complete Response Letter for RISPERDAL(R) CONSTA(R) for the Adjunctive Maintenance Treatment of Bipolar Disorder
2. Santaris Pharma Director Appointed Adjunct Professor in RNA Biology at the University of Aalborg, Denmark
3. Breast-Specific Gamma Imaging In Clinical Practice as an Adjunct Imaging Modality for Diagnosis of Breast Cancer
4. Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy
5. FDA Grants Priority Review for Schering-Ploughs Peginterferon Alfa-2b for the Adjuvant Treatment of Patients With Stage III Melanoma
6. Helix BioPharma Receives Approval to Initiate Phase II Pharmacokinetic Clinical Study of Topical Interferon Alpha-2b in Patients with Low-Grade Cervical Lesions
7. Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients
8. Web Resource for Interferon Research
9. Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
10. Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo
11. UCB Announces New Data Showing Investigational Drug Lacosamide Significantly Reduced Seizures in Refractory Epilepsy Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 Automated cell culture ... maintenance of cell culture. They allow production of optimum ... of researchers in drug discovery and industries and biopharmaceutical ... mAb production, iPSC research, cryobanking, cell-based assays, and cellular ... risk. , Analysts forecast the Global Cell Culture ...
(Date:7/22/2014)... 22, 2014 Two new members were ... Directors at its annual Shareholders Meeting on June 13: ... of The PFM Group, and Stephen T. Zarrilli, President ... announced the election of Michael A. DiPiano, Managing General ... and Richard P. Jaffe, Esq., of Duane Morris LLP, ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
(Date:7/22/2014)... SHENZHEN, China , July 22, 2014 /PRNewswire/ ... a subsidiary of BGI, the world,s largest genomics ... new human whole exome sequencing service based on ... includes in-depth bioinformatics analysis and SNP validation, and ... 2014. Complete Genomics, highly regarded ...
Breaking Biology Technology:Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3
... receive funding for technology development projects from the ... Grant program. , ,The TAG program provides grants ... companies to offset the cost of professional services. ... Automated Notification Systems, Inc. , Eau Claire; Micrablate, ...
... the balkanization of information technology in healthcare will take ... Digital Healthcare Conference 2006 . And vendors aren't necessarily ... customers. , ,Providers are facing that common IT problem: ... of vendors and systems with challenges agreeing to standards, ...
... a gathering of health professionals attending the eHealth Summit ... first state to have a fully integrated electronic medical ... barriers. , ,Speaking before a group of healthcare executives, ... state's eHealth Initiative, Doyle said those barriers include organizational ...
Cached Biology Technology:Being proactive with vendors helps healthcare improve IT 2Doyle asks health professionals to overcome barriers 2Doyle asks health professionals to overcome barriers 3
(Date:7/22/2014)... cells offer much promise for treating damaged organs and ... is poor, limiting their effectiveness. New methods are being ... their therapeutic function after transplantation, as described in a ... peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The ... Access website . , In the ...
(Date:7/22/2014)... July 22, 2014 BGI Tech Solutions Co., ... world,s largest genomics organization, announced today the global ... service based on Complete Genomics, industry-leading platform. This ... SNP validation, and is available at reduced prices ... highly regarded in the industry for providing proprietary ...
(Date:7/22/2014)... emerging as a world-famous vacation spot with natural tourism resources, ... island. The Korea Institute of Geoscience and Mineral Resources (KIGAM) ... recent volcanic eruption was evident 5,000 years ago. That is ... lava spewed out of a volcano 5,000 years ago in ... one the whole peninsula. , The research team led by ...
Breaking Biology News(10 mins):BGI Tech launches human whole exome sequencing service on complete genomics' advanced platform 2Jeju Island is a live volcano 2
... some amphibians possess a unique sensory capability in the ... "touch" objects in their surroundings without direct physical contact ... Hermmen and his team in the physics department of ... for this sensory system. What they discover might one ...
... A method to detect contaminants in municipal water supplies ... Laboratory researchers whose findings are published on line in ... demonstrates that the technology that uses algae as sentinels ... Miguel Rodriguez Jr. and Elias Greenbaum of the Department ...
... to the "hardwired for news" theory, people devote more ... test the theory, University of Missouri researchers examined the ... researchers found that news about local health threats increased ... distant, or non-local, health threats. "Although journalists ...
Cached Biology News:Mathematical keys to a sixth sense -- the lateral-line system 2Mathematical keys to a sixth sense -- the lateral-line system 3Mathematical keys to a sixth sense -- the lateral-line system 4ORNL scientists hone technique to safeguard water supplies 2Online news garners more attention from readers if it's negative and localized, MU study finds 2
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... is designed to purify double-stranded DNA (dsDNA) generated ... PCR. The process is simple and fast. DNA ... can be efficiently purified and concentrated. The DNAclear ... bound to the Microfilter Cartridge in the presence ...
Normal donkey serum collected from healthy normal donkeys....
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Biology Products: