Navigation Links
Tenfold boost in ability to pinpoint proteins in cancer cells
Date:3/19/2013

Better diagnosis and treatment of cancer could hinge on the ability to better understand a single cell at its molecular level. New research offers a more comprehensive way of analyzing one cell's unique behavior, using an array of colors to show patterns that could indicate why a cell will or won't become cancerous.

A University of Washington team has developed a new method for color-coding cells that allows them to illuminate 100 biomarkers, a ten-time increase from the current research standard, to help analyze individual cells from cultures or tissue biopsies. The work is published this week (March 19) in Nature Communications.

"Discovering this process is an unprecedented breakthrough for the field," said corresponding author Xiaohu Gao, a UW associate professor of bioengineering. "This technology opens up exciting opportunities for single-cell analysis and clinical diagnosis."

The research builds on current methods that use a smaller array of colors to point out a cell's biomarkers characteristics that indicate a special, and potentially abnormal or diseased, cell. Ideally, scientists would be able to test for a large number of biomarkers, then rely on the patterns that emerge from those tests to understand a cell's properties.

The UW research team has created a cycle process that allows scientists to test for up to 100 biomarkers in a single cell. Before, researchers could only test for 10 at a time.

The analysis uses quantum dots, which are fluorescent balls of semiconductor material. Quantum dots are the smaller version of the material found in many electronics, including smartphones and radios. These quantum dots are between 2 and 6 nanometers in diameter, and they vary on the color they emit depending on their size.

Cyclical testing hasn't been done before, though many quantum dot papers have tried to expand the number of biomarkers tested for in a single cell. This method essentially reuses the
'/>"/>

Contact: Michelle Ma
mcma@uw.edu
206-543-2580
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. New semiconductor research may extend integrated circuit battery life tenfold
2. Are Pros "Cheating" with Undetectable HGH Boosters?
3. Genuine Bio-Fuel Inc. Notes Sustainable Energy Gets A Much Needed Boost from the President Obama During 2013 Inaugural Address
4. Genedata Biologics 3.0 Boosts Efficiency Through Standardization
5. Tiny structure gives big boost to solar power
6. Nature Materials study: Boosting heat transfer with nanoglue
7. Industrial carbon management research gets $3.75 million boost
8. A 300 Million Euro Boost for Biomedicine in Berlin
9. Rice team boosts silicon-based batteries
10. LLSs Lead Therapy Acceleration Program in MDS Gets Boost from Major Industry Licensing Agreement
11. Spinach power gets a big boost
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tenfold boost in ability to pinpoint proteins in cancer cells
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... A study has been launched to test whether ... could help to tackle the problem of obesity.  This unique ... surgery based in Stowmarket) and academics at University Campus Suffolk ... technology, which is inspired by equipment used to collect data ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... (Nasdaq: FOLD ) today announced it plans to initiate ... drug in development for the treatment of Pompe Disease. ... pharmacokinetics of AT2220 in muscle tissue in healthy adult subjects. ... to Amicus, proposal for the Phase 1 study and subsequently ...
... PARIS, September 30 , ... to Achieve Similar, Well,Tolerated Glycemic Control Versus Lantus(R) , ... ) announced today results of a,head-to-head study providing further evidence ... [rDNA] injection) compared,to twice-daily insulin detemir. The study was presented ...
... John McPherson, Platform Leader, Cancer Genomics and High-Throughput Screening, ... Institute for Cancer Research (OICR) led a team of ... NEBNext(TM) DNA Sample Prep Reagents for use with OICR,s ... evaluation, "We are constantly striving for the best quality ...
Cached Biology Technology:Amicus Therapeutics Announces Plan to Initiate Phase 1 Study of AT2220 for Pompe Disease 2Amicus Therapeutics Announces Plan to Initiate Phase 1 Study of AT2220 for Pompe Disease 3Amicus Therapeutics Announces Plan to Initiate Phase 1 Study of AT2220 for Pompe Disease 4Superior Efficacy-dose Ratio for Lantus(R) Over detemir 2Superior Efficacy-dose Ratio for Lantus(R) Over detemir 3Superior Efficacy-dose Ratio for Lantus(R) Over detemir 4Superior Efficacy-dose Ratio for Lantus(R) Over detemir 5Ontario Institute for Cancer Research Validates NEBNext(TM) DNA Sample Preparation Reagents from New England Biolabs for use in Next Generation Sequencing 2
(Date:7/9/2014)... about the prevalence of antibiotic-resistant illness, Case Western ... to disabling disease: blocking bacteria,s access to iron ... bacterial siderophore, a small molecule, captures iron from ... as well as how the body launches ... findings appear in a recent edition of ...
(Date:7/9/2014)... may be able to cope with the rising salinity of ... Arctic today is best known for its tundra and polar ... to 38 million years ago during what is known as ... huge temperate forest with brackish water, home to a variety ... and giant tortoises. Much of what is known about the ...
(Date:7/9/2014)... but often can be defeated with antibiotics and then ... Now, scientists have built a new weapon against such pathogens ... journal ACS Applied Materials & Interfaces , their study ... them than medicine alone. , David Leong, Jianping Xie and ... undetectable in the human body or in places that antibiotics ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... compound found in green tea shows great promise for ... tumors and a deadly congenital disease. The discovery ... Dr. Thomas Smith at The Donald Danforth Plant Science ... Philadelphia. Their findings are published in the recent article, ...
... A research team led by St. Jude Children,s ... for treatment of the childhood eye tumor retinoblastoma. Their ... cancer,s cellular origins are as scrambled as the developmental ... cancers that resemble a particular type of cell, researchers ...
... New research suggests that blood stem cells can be involved ... caused by the abnormal proliferation of mature cells. The study, ... the journal Cancer Cell , may guide future strategies ... CLL is a cancer of a type of mature ...
Cached Biology News:Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors 2Childhood eye tumor made up of hybrid cells with jumbled development 2Childhood eye tumor made up of hybrid cells with jumbled development 3Stem cells central to pathogenesis of mature lymphoid tumors 2
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
Request Info...
... labware. Waterproof, moisture-proof film prevents sample ... be folded repeatedly and twisted around ... at 21C (70F), wrapping film increases ... removed, film only partially returns to ...
...
Biology Products: