Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cance...( PALO ALTO Calif. April 17 /- Teli...)

PALO ALTO, Calif., April 17 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK), a biopharmaceutical company focused on discovering and developing drugs to treat serious diseases, today announced that it made four preclinical data presentations at the 99th Annual Meeting of the American Association for Cancer Research (AACR) in San Diego, Calif. The abstracts highlighted results from Telik's Research and Development programs.

Identification and Characterization of Novel Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor Receptor 2 [Abstract # 1439]

Inhibition of the vascular endothelial growth factor receptor signaling

pathway with antibodies or small molecules has been proven effective as an

anti-cancer therapy. Through the use of Telik's Target-Related Affinity

Profiling (TRAP(R)) screening technology, novel inhibitors of VEGFR2

kinase were discovered. The inhibitors belong to nine structural classes,

among which E2B8 and EAAF are sub-micromolar inhibitors of the kinase.

Mechanism of Induction of Apoptosis by TLK199 (TELINTRA(R)) in Human Leukemia Cell Lines [Abstract # 2270]

Telik researchers conducted studies with data highlighting TLK199, a novel

glutathione analog inhibitor of the enzyme glutathione S-transferase P1-1,

which induces apoptosis, or programmed cell death, in human HL60

promyelocytic cells and TF-1 erythroleukemic cells. Treatment of the

leukemia cells with TLK199 also resulted in an increase of the

phosphorylation of eIF2alpha, a key signaling event in the integrated

stress response (ISR), and in induction of multiple genes implicated in

ISR. Telik currently has ongoing studies of T
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