Navigation Links
Telik Announces Top-Line Results From Assist-5 Trial of Telcyta(R) in Combination With Pegylated Liposomal Doxorubicin in Platinum Refractory and Resistant Ovarian Cancer
Date:10/29/2008

PALO ALTO, Calif., Oct. 29 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK) today announced top-line results from an interrupted Phase 3 randomized study of Telcyta (canfosfamide HCL) in combination with pegylated liposomal doxorubicin (PLD) versus PLD alone in second-line therapy in platinum refractory, primary platinum resistant or secondary platinum resistant ovarian cancer (definitions of platinum status are provided below).

On an intent-to-treat (ITT) basis for the 125 enrolled patients, the median progression-free survival (PFS) was 5.6 months on the Telcyta plus PLD arm compared to 3.7 months on the PLD control arm, p = 0.7243 and hazard ratio (HR) = 0.92. The study did not meet the statistical significance p less than or equal to 0.05. The overall response rate as measured by RECIST was 12%, including one complete response (CR) for the Telcyta plus PLD arm and 8% for the PLD control arm.

Of the 125 patients in the ITT population, a prespecified analysis was conducted for 75 patients with platinum refractory or primary platinum resistant disease, including 40 patients on the Telcyta plus PLD arm and 35 patients on the PLD control arm. The median PFS of these patients was 5.6 months for the Telcyta plus PLD arm compared to 2.9 months for the PLD control arm, p = 0.0425 and HR = 0.55. The response rate, as assessed by RECIST, was 15%, including one CR for the Telcyta plus PLD arm and 6% for the PLD control arm.

The initial trial design provided for the enrollment of 244 patients. The trial was interrupted by a brief clinical hold, followed by a partial clinical hold from June 2007 until October 2007. At the time of the clinical hold, 125 patients had been enrolled in the trial. Although enrollment was permitt
'/>"/>

SOURCE Telik, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Telik Announces 2008 Third Quarter Financial Release, Conference Call and Webcast
2. Telik Announces Receipt of Nasdaq Notice
3. Teliks Aurora Kinase-VEGFR Dual Inhibitor Program Meets a Preclinical Development Milestone
4. ReceptorBio Announces Diabetes License Agreement With Telik
5. Telik Announces Financial Results For 2008 Second Quarter
6. Telik Announces 2008 Second Quarter Financial Release, Conference Call and Webcast
7. Telik Announces Publication of Diabetes Research in Bioorganic & Medicinal Chemistry Letters
8. Telik Announces Presentation and Webcast at Needham Biotechnology Conference
9. Telik Announces First Quarter 2008 Financial Results
10. Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research
11. Telik Announces Fourth Quarter and 2007 Year End Financial Results and 2008 Guidance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The laboratory information management systems market is a rapidly ... advancements due to factors such as rising pressure to ... systems, and increasing government support for adoption of HCIT ... in the market focus on technological advancements to further ...
(Date:1/22/2015)... 22, 2015 zFlo Motion , a ... announce an exciting product from a new partner. STT-Systems ... over the past 15 years, with offerings in the optical-motion ... 3D IMU system (inertial measurement unit), iSen, is opening eyes ...
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... Sept. 14 BioSpecifics Technologies Corp. (Nasdaq: ... collagenase-based products, today announced that BioSpecifics, President, Tom Wegman, ... Conference on Monday, September 20, 2010, at 7:30am ET ... City. A live webcast of the presentation ...
... a leading domain name development company, will release a list ... off on September 16, at 1:30 pm at the ... domain auction is part of the inaugural Epik.com Domain ... live auction event is open to the public. ...
... N.J., Sept. 14 Innophos Holdings, Inc. (Nasdaq: ... announced that Randy Gress, Chief Executive Officer, will address the ... 30, 2010 at 8:00 a.m. (Eastern Time).   ... please go to www.innophos.com Investor Relations Events section. ...
Cached Biology Technology:DNASequencing.com and a Portfolio of 318 'Genetic' Domain Names to be Auctioned Off at Epik.com Domain Development Conference 2
(Date:1/22/2015)... 2015 , Europe,s ... The European Patent Office to present a video retrospective of the ... be featured: Christofer Toumazou and Sophie Wilson   ... winners of the Award   Starting on 22 January ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its launch in ... of people to eliminate the pain of trying to remember ... their own biometrics fused to their smartphones. To assist people ... Labs , the company that created 1U and focuses on ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 31U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... to rethink their fall tree plantings. Warming temperatures have ... planting guidelines obsolete, according to Dr. Nir Krakauer, assistant ... New York,s Grove School of Engineering. Professor ... in the United States that takes rapidly rising temperatures ...
... whales have the longest menopause of any non-human species - to ... and York and published in the journal Science (14 ... the death of his mother means an almost 14-fold-increase in the ... for the menopause remains one of nature,s great mysteries and very ...
... Research Careers) Program has announced the travel award recipients ... (ASBMR) Annual Meeting in Minneapolis, MN from October 12-16, ... entry of underrepresented minority students, postdoctorates and scientists into ... encourage the participation of young scientists at the 2012 ...
Cached Biology News:Warmer temperatures make new USDA plant zone map obsolete 2Long menopause allows killer whales to care for adult sons 2Long menopause allows killer whales to care for adult sons 3
... in your 35mm dish without transferring ... Chamber has separate openings for solution ... fluctuations of the liquid level in ... from entering the chamber. An adjustable ...
... Five cells (BTI-TN-5B1-4) derived from Trichoplusia ... shown to be capable of expressing ... proteins compared to other insect cells. ... features:- -Rapid doubling time as adherent cultures- Quick ...
... steadylite plus assay system offers ... sensitivity, Designed for batch-processing systems, ... higher density microplates such as ... free, Convenient storage conditions ( ...
... This kit consists of universal lysis buffer, ... primers for 100 25 l volume PCR ... of Gram negative or positive rod and ... Pneumoniae, Bacillus Cereus, Staphylococcus Aureus, Streptococcus Agalactiae, ...
Biology Products: