Navigation Links
Technology brings new life to the study of diseases in old bones
Date:10/25/2012

A study led by The University of Manchester has demonstrated that new technology that can analyse millions of gene sequences in a matter of seconds is an effective way to quickly and accurately identify diseases in skeletons.

Professor Terry Brown, working in partnership with Professor Charlotte Roberts from Durham University, used a next generation sequencing approach, including hybridization capture technology, to identify tuberculosis genes in a 19th century female skeleton found in a crypt in Leeds.

Their study is part of wider research into the identification of strains of TB in skeletons dating from 100 AD to the late 19th century. It's hoped that understanding how the disease has evolved over time will help improve treatments and vaccines. TB rates have been increasing around the world, and it's estimated that one third of the world's population has latent TB. After HIV it kills more people than any other infectious disease.

Certain strains of TB affect the sufferer's bones, especially in the spine. The marks made by the disease remain evident on the bones long after the person's death. It's this evidence that Professor Roberts used to find suitable skeletons to screen for tuberculosis genes.

She sourced 500 skeletons from across Europe that showed evidence of TB dating from the Roman period to the 19th century. Bone samples from these skeletons were screened for TB DNA, and of those 100 were chosen for this particular study.

Professor Roberts explains: "So many skeletons were needed as it's very hard to tell if any DNA will have survived in the bones. You don't really know if there will be any present until you start screening and in the past that has been a lengthy process."

Professor Terry Brown then took on the search for TB DNA in the skeletons. Each small section of bone was ground up and placed in a solution. That was then put in a special machine which captured every gene sequence in the DNA
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. New HIV prevention technology shows promise
2. Tel Aviv University to spearhead groundbreaking nanotechnology consortium
3. Germany Prioritizes Medical Biotechnology with New Initiatives
4. New Report: "Innovations in Drug Delivery - Broad-based Proprietary Technology Platforms to Address Delivery Efficiency and Improve Patient Compliance" Now Available at Twease.org
5. Islet Sciences Announces Exclusive License Agreement with Winthrop University Hospital to Commercialize a Beta Cell Loss Measurement Technology in Diabetes
6. Algae.Tec Biofuels Technology to Feature at 2012 ILA Berlin Airshow
7. Indian Pharma MNC Piramal Investing in German Molecular Imaging Technology
8. Biomass characterization technology research highlighted in Industrial Biotechnology journal
9. Breakthrough in nanotechnology
10. Bolder BioTechnology Announces Publication of Data Demonstrating Utility of the Companys Long-Acting IL-11 Analog to Prevent Renal Ischemia Reperfusion Injury
11. Bode Technology Offers First Rapid DNA Service Delivering a DNA Profile from Evidentiary Samples in Under 90 Minutes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... 2014 The Alliance for Safe ... of European physicians at the "1 ST ... Therapies" at the Spanish Ministry of Health, Social ... and the Spanish Bioindustry Association (ASEBIO), included regulators ... Spanish oncology and rheumatology societies, representatives from a ...
(Date:11/26/2014)... November 26, 2014 The ETC ... award-winning technology innovation centers, announced today that applications ... on December 1st. “Do you have a big ... I want to know about it. AccelerateBaltimore helps ... to product in just 13 weeks.” Interested ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to ... County (New Jersey) Chamber of Commerce as a ... organization in the North Jersey area, offers Whitehouse ... key clients in the pharmaceutical and biotechnology areas ... Membership enables Whitehouse Laboratories a higher level of ...
(Date:11/26/2014)... Sunnyvale, CA (PRWEB) November 25, 2014 ... joins forces with RPM Alliance , provider ... and pharmaceutical companies. With the latest addition to its ... only free validated EDC system to India. , ... as a robust and customizable EDC platform which is ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2
... ... Ohio, just west of Cleveland, now offers reverse total shoulder replacement surgery. This innovative ... Until now, these individuals -- who are not candidates for traditional shoulder replacement -- ... ...
... Researchers have completed the first thorough, system-level assessment ... of microbes known as Shewanella. Microbes belonging to ... and cleaning up contaminated areas in the environment. ... Institute of Technology, Michigan State University and the ...
... 31 A high-tech device that expands the visual field ... in a walking simulator, according to scientists at Schepens Eye ... of Investigative Ophthalmology and Visual Science. The study found ... camera, pocket-sized computer and a transparent computer display on a ...
Cached Biology Technology:Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 2Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 3Robert Zanotti, MD, Is First Lorain County, Ohio Orthopedic Surgeon to Perform Reverse Total Shoulder Replacement 4Hidden diversity in key environmental cleanup microbes found by systems biology assessment 2Hidden diversity in key environmental cleanup microbes found by systems biology assessment 3New Vision Device Passes Virtual Collision Test for People with Tunnel Vision 2New Vision Device Passes Virtual Collision Test for People with Tunnel Vision 3
(Date:11/6/2014)... asset for a predator. Except when that predator runs so ... relative to its size, is the fastest creature on Earth. ... per second (at about five miles per hour). The fastest ... sprinting gold from the tiger beetle, a person would have ... beetle has a problem. At peak speeds, everything becomes a ...
(Date:11/5/2014)... his career to understanding the Earth,s climate and ... As deputy director and regional climatologist for the ... Institute, Redmond has more than three decades of ... climate data to the general public. , At ... on December 15-19, 2014 the American Geophysical Union ...
(Date:11/4/2014)... the right time might actually help boost a species, ... in understanding animal populations, pest control and managing fish ... journal Trends in Ecology and Evolution , a ... kind of positive population effect an overall species experiences ... the size and developmental stage of the creatures that ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2When less is more: Death in moderation boosts population density in nature 2
... which contain codeine may be risky for some,breastfeeding mothers, ... and the Hospital for Sick Children (SickKids) in Toronto.,Lead ... Clinical Pharmacology & Therapeutics which suggests that ... actually have harmful and even fatal results for infants ...
... that an interdisciplinary and coordinated research agenda can have ... a group of experts has developed a roadmap for ... marine ecosystem and into the fish we eat. ... group of 43 leading scientists, environmental regulators, and public ...
... But to do that they have to provide digital as ... led by William Maisel at Harvard Medical School demonstrated how ... communications from a pacemaker ( New Scientist, 22 March, ... adjust the implanted device, but a malicious hacker could reprogram ...
Cached Biology News:Codeine not safe for all breastfeeding moms and their babies 2Dartmouth workshop sets research agenda for environmental mercury 2How to stop a new type of heart attack 2
... system for fluorescent light due to small ... camera to detect low level light in ... disease research, gene expression, circadian rhythm, gels ... imager with a motor-driven camera inside the ...
Mouse polyclonal antibody raised against a partial recombinant TSEN2. NCBI Entrez Gene ID = 80746...
Mouse monoclonal antibody raised against a partial recombinant RAB11B. NCBI Entrez Gene ID = RAB11B...
...
Biology Products: