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Taksta™ (fusidic acid) Demonstrates Activity Against MRSA Isolated From Cystic Fibrosis Patients
Date:11/3/2011

diate their therapeutic effects.  Earlier work showed that pretreatment of primary human bronchial epithelial cultures with azithromycin prevented up-regulation of inflammatory and defense response genes generated by exposure to supernatant from mucopurulent material (SMM) from CF airways.  In this study, Ribeiro et al. (Abst. # 219) showed that pretreatment with solithromycin, along with azithromycin and telithromycin, inhibited SMM-induced expression of mRNA of inflammatory genes, particularly MUC5B (mucin-5B) and MUC5AC (mucin-5AC).  Because of chronic lung inflammation found in CF patients, the anti-inflammatory activity demonstrated in this study could provide a path for the development of new therapeutic agents for CF.

About Cempra Pharmaceuticals

Founded in 2006, Cempra Pharmaceuticals is a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical unmet medical needs in the treatment of bacterial infectious diseases, particularly respiratory tract infections and skin and skin structure infections. Our two lead product candidates have both completed oral Phase 2 clinical trials and seek to address the need for new treatments targeting drug-resistant bacterial infections in the hospital and in the community. The company also intends to use its proprietary macrolide library and chemistry technology to develop novel macrolides without antibacterial activity for non-antibiotic uses such as inflammatory and GI disorders. Additional information about Cempra can be found at www.cempra.com.

Contacts:

Robert E. Flamm, Ph.D.
Russo Partners, LLC
(212) 845-4226
Robert.flamm@russopartnersllc.com

Tony Russo, Ph.D.
Russo Partners, LLC
(212) 845-4251
Tony.russo@russopartnersllc.com

Prabhavathi Fernandes,
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