Navigation Links
TOPICA Pharmaceuticals Announces Sublicensing Agreement for Tinea Indication
Date:9/21/2010

PALO ALTO, Calif., Sept. 21 /PRNewswire/ -- TOPICA Pharmaceuticals, Inc. a privately-held biotechnology company, today announced that it has entered into a sublicense and purchase option agreement with an undisclosed partner to develop luliconazole exclusively for tinea infections of the skin in the Americas and Europe. By agreement, additional terms of the deal were not disclosed.

In conjunction with the sublicensing agreement, TOPICA Pharmaceuticals will now focus on developing luliconazole exclusively for the treatment of onychomycosis.  In February of 2010 the company's IND for onychomycosis was opened, paving the way for human clinical trials to begin later in 2010.  

"We are looking forward to the initiation of luliconazole's clinical development program this fall and validating the molecule's promising preclinical profile in onychomycosis.  If the molecule's preclinical profile is validated, luliconazole has the potential to be the first truly effective, safe and convenient topical therapy for onychomycosis; providing physicians and patients with a much needed alternative to currently available oral anti-fungal therapies that have risk of serious adverse events," said Greg Vontz, president & CEO of TOPICA Pharmaceuticals.  

"This is a unique and well aligned transaction that will help to maximize the future potential of the molecule by partnering luliconazole with a well resourced partner and then advancing the molecule in a dedicated effort focused on resolving a long-standing medical need by providing an effective and safe topical therapy for onychomycosis," said Alex Barkas, TOPICA board member and managing director of Prospect Venture Partners.  "We are pleased with the arrangement and the shareholder value we believe will result." TOPICA's existing investors will lead an additional financing for the onychomycosis company.

About Luliconazole

Luliconazole is one of the most potent and broad-spectrum topical antifungal agents. Going forward TOPICA Pharmaceuticals will be developing luliconazole for onychomycosis, which affects approximately 35 million people in the U.S. Currently approved therapies for onychomycosis are either marginally effective or are complicated by the potential of liver toxicity and require hepatic monitoring.  In numerous rigorous preclinical models of onychomycosis, luliconazole has demonstrated rapid penetration and therapeutically effective levels in the nail bed.  This preclinical profile suggests luliconazole has the potential to be the first highly effective and safe topical therapy for onychomycosis.   The potential annual U.S. market for onychomycosis treatment is estimated at approximately $3 billion.  

TOPICA has an exclusive license from Nihon Nohyaku Co., Ltd. to develop and market luliconazole for onychomycosis in the Americas and Europe.

About TOPICA Pharmaceuticals, Inc.

TOPICA Pharmaceuticals, Inc. is a privately-held specialty pharmaceutical company focused on licensing, developing and commercializing topical prescription products to treat the needs of patients with serious nail and skin conditions. Taking advantage of its established trans-Pacific network of scientific and industry contacts, TOPICA has in-licensed its lead product candidate, luliconazole, a topical antifungal agent that is already on the market in Japan. TOPICA has been developing luliconazole for the treatment of tinea pedis (athlete's foot) which will now be developed by an undisclosed partner pursuant to a sublicense agreement.  Going forward, TOPICA will be focused on onychomycosis (fungal infections of the nail). For more information, please visit http://www.topicapharma.com.


'/>"/>
SOURCE TOPICA Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Xenon Pharmaceuticals Initiates a Phase 2 Clinical Trial in Post Herpetic Neuralgia (PHN) for Topical XEN402.
2. Soligenix Announces Grant of Broad European Patent for Topically Active Steroids to Treat Inflammatory Gastrointestinal Disorders
3. Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds
4. Transdel Pharmaceuticals to Host Conference Call and Webcast on Tuesday, October 6, 2009 to Announce Top-Line Phase 3 Study Results for Lead Topical Pain Drug Ketotransdel(R)
5. Topical erectile dysfunction therapy shows promise
6. Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens
7. Innocoll Announces Provisional Findings From Its Three Phase 2 Clinical Trials Investigating CollaRx(R) GENTAMICIN TOPICAL for the Treatment and Prevention of Diabetic Foot Infections
8. Helix BioPharma Receives Approval to Initiate Phase II Pharmacokinetic Clinical Study of Topical Interferon Alpha-2b in Patients with Low-Grade Cervical Lesions
9. Cerimon Pharmaceuticals Initiates Phase III Clinical Studies to Evaluate Its Topical Diclofenac Sodium Patch for Mild-to-Moderate Pain
10. Pilot Study Finds Adding Topical Imiquimod To Laser Therapy Improves The Response Of Port Wine Stain Birthmarks
11. Sigma-Aldrich Signs Exclusive Agreement With IsoSciences, LLC, to Distribute Isotopically Labeled Bioactive Compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... Researchers from a new study are stating that if levels of ... cancer treatment, this indicates there is still remaining prostate cancer cells that are more likely ... test has always been an indicator of whether a man’s prostate cancer is growing ...
(Date:1/18/2017)... 2017 Shareholder rights law firm Johnson & ... board members of CoLucid Pharmaceuticals, Inc. (NASDAQ: ... the proposed sale of the Company to Eli Lilly ... small molecules for the acute treatment of migraines. ... signed a definitive merger agreement with Eli Lilly. Under ...
(Date:1/17/2017)... ... January 17, 2017 , ... LGC Maine ... its VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 evaluates Albumin, ... VALIDATE® SP2 kit is prepared using the CLSI recommended “equal delta” method for ...
(Date:1/17/2017)... , Jan. 17, 2017  Zimmer Biomet Holdings, Inc. ... and full-year 2016 sales and earnings conference call will ... 31, 2017, at 8 a.m. Eastern Time.  A news ... made available at 7:30 a.m. Eastern Time the morning ... webcast can be accessed via Zimmer Biomet,s Investor Relations ...
Breaking Biology Technology:
(Date:1/11/2017)... MOINES, Iowa , Jan. 11, 2017 ... industry first with the release of its patent-pending calibration ... quickly and reliably perform calibrations, securely upload data logs ... flexibility for the customer. "Fighting drunk driving ... only for the public at large, but also for ...
(Date:1/4/2017)... 2017  For the thousands of attendees at this year,s International Consumer ... health and biometric measurement devices and services, will be featuring its new ... in A&D Medical,s special CES Exhibit Suite , the new upper ... the company,s WellnessConnected product platform.  ... ...
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
Breaking Biology News(10 mins):