There remains a critical need for effective, well tolerated therapies for MDS. Telintra has a novel mechanism of action that inhibits an enzyme called glutathione S-transferase P11 which may activate JNK kinase, a key regulator of cellular growth and differentiation of blood precursor cells. Telintra has been shown to stimulate normal multilineage differentiation of blood stem cell precursors and induce cancer cell death, or apoptosis, in human leukemia cell lines. Telintra is currently being evaluated in Phase 2 studies alone and in combination in patients with Low to Intermediate-1 Risk Myelodysplastic Syndrome and in Severe Chronic Neutropenia.
Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer. The company's most advanced drug candidates in clinical development are Telintra, a modified glutathione analog for the treatment of MDS and Severe Chronic Neutropenia (SCN), and Telcyta®, a cancer activated prodrug for the treatment of advanced non-small cell lung cancer and ovarian cancer. Telik's product candidates were discovered using its proprietary drug discovery technology, TRAP®, which enables the rapid and efficient discovery of small molecule drug candidates.
This press release contains "forward looking" statements regarding the future development of Telintra, the effectiveness of Telintra in treating MDS alone and in combination with other drugs, the effectiveness of Telintra in treating Severe Chronic Neutropenia and other hematologic diseases, the effect of Telintra on leukemia cells and blood cell growth and differentiation, and the use of Telcyta for the treatment of advanced non-small cell lung cancer
|SOURCE Telik, Inc.|
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