Navigation Links
TELINTRA® Named One of the 10 Most Interesting Oncology Projects to Watch
Date:10/26/2010

PALO ALTO, Calif., Oct. 26 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) announced today that Telintra (Ezatiostat HCl), the company's lead therapeutic product candidate, has been selected by Windhover Information and its advisors as one of "The Top 10 Most Interesting Oncology Projects to Watch."  Windhover is a leading provider of business information to senior executives in the pharmaceutical, biotechnology, and medical device industries.  The company has been invited to present at Windhover's Therapeutic Area Partnerships conference on November 3, 2010 in Boston, MA.

Telintra is among the first therapeutic products in a novel class of small-molecule drug candidates which inhibit the enzyme glutathione S-transferase P1-1 for the treatment of malignancies, including myelodysplastic syndrome (MDS) and hematologic diseases characterized by cytopenias.  Telintra may induce apoptosis, or cellular death, in leukemia cells and cause differentiation and proliferation of normal bone marrow blood cell precursors, leading to an increase in platelets, red cells, and white cells.

Telintra has recently completed a positive Phase 2 study in patients with Low to Intermediate Risk-1 MDS and has shown evidence of clinical activity and tolerability in multiple Phase 1 and Phase 2 clinical studies.

About MDS and Telintra

The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis (blood cell production) involving one or more cell lineages (red blood cells, white blood cells, or platelets) and a variable risk of transformation to acute myeloid leukemia (AML).  MDS becomes more common with age.  It is estimated that MDS affects approximately 300,000 people worldwide.  According to the American Cancer Society, 10,000–20,000 new cases of MDS are diagnosed each year in the United States, with survival rates ranging from six months to six years.  MDS patients often require blood transfusions to manage their disease.

There remains a critical need for effective, well tolerated therapies for MDS.  Telintra has a novel mechanism of action that inhibits an enzyme called glutathione S-transferase P11 which may activate JNK kinase, a key regulator of cellular growth and differentiation of blood precursor cells.  Telintra has been shown to stimulate normal multilineage differentiation of blood stem cell precursors and induce cancer cell death, or apoptosis, in human leukemia cell lines.  Telintra is currently being evaluated in Phase 2 studies alone and in combination in patients with Low to Intermediate-1 Risk Myelodysplastic Syndrome and in Severe Chronic Neutropenia.

About Telik

Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer.  The company's most advanced drug candidates in clinical development are Telintra, a modified glutathione analog for the treatment of MDS and Severe Chronic Neutropenia (SCN), and Telcyta®, a cancer activated prodrug for the treatment of advanced non-small cell lung cancer and ovarian cancer.  Telik's product candidates were discovered using its proprietary drug discovery technology, TRAP®, which enables the rapid and efficient discovery of small molecule drug candidates.

This press release contains "forward looking" statements regarding the future development of Telintra, the effectiveness of Telintra in treating MDS alone and in combination with other drugs, the effectiveness of Telintra in treating Severe Chronic Neutropenia and other hematologic diseases, the effect of Telintra on leukemia cells and blood cell growth and differentiation, and the use of Telcyta for the treatment of advanced non-small cell lung cancer and ovarian cancer.  These forward looking statements are based upon Telik's current expectations.  Detailed information regarding factors that may cause actual results to differ materially from the results expressed or implied by statements in this press release may be found in Telik's periodic filings with the Securities and Exchange Commission, including the factors described in the section entitled "Risk Factors" in its quarterly report on Form 10-Q for the quarter ended June 30, 2010.  Telik does not undertake any obligation to update forward looking statements contained in this press release.

Telik, the Telik logo, TELINTRA, TELCYTA and TRAP are trademarks or registered trademarks of Telik, Inc.


'/>"/>
SOURCE Telik, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. William F. Prendergast Named One of the Top IP Lawyers in Nanotechnology
2. CV Therapeutics Announces Ranexa(R) Named Finalist for Prix Galien USA 2008 Award
3. Bill Pollock, President and CEO of Pharmagistics Group, Named to PharmaVOICE List of 100 Most Inspiring and Influential Leaders in the Life Sciences
4. Integrated Project Management Named to "Inc. 5000" for Second Year : One of the Top 100 Fastest-Growing Companies in Chicago Area
5. IDIS Opens New American Office in Response to Industrys Growing Need for Pre-Launch Named Patient Programs
6. Baxa Corporation Named to Inc. 5000 for Second Consecutive Year as One of the Fastest-Growing Private Companies in the US
7. Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc
8. Concentric Named Professional Agency of Record for Discovery Labs SURFAXIN(R)
9. Expression Genetics EGEN-001 Named One of 10 Most Promising Oncology Products by Windhover
10. Baxter Named to Dow Jones Sustainability Index for Tenth Consecutive Year
11. NovaVision CEO Named Presenter at the AdvaMed 2008 Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... , ... December 08, 2016 , ... ... to control cells — optogenetics — is key to exciting advances in the ... art, spatially patterned light projected via free-space optics stimulates small, transparent organisms and ...
(Date:12/8/2016)... 8, 2016 Oxford ... erweitert seine Palette an anpassbaren SureSeq™ NGS-Panels mit ... Panels, das ein schnelles und kostengünstiges Studium der ... bietet eine Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, ... einzigen kleinen Panel und ermöglicht eine individuelle Anpassung ...
(Date:12/8/2016)... 8, 2016  Anaconda BioMed S.L., a pre-clinical stage ... next generation neuro-thrombectomy system for the treatment of Acute ... Jovin, MD to join its Scientific Advisory Board (SAB). ... network of scientific and clinical experts to Anaconda BioMed ... ANCD BRAIN ® to its clinical phase. The ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... packaging for their exceptionally efficient human mesenchymal stem/stromal cell (hMSC) expansion medium. ... bioprocess media products engineered to radically streamline culture processes, minimize processing time, ...
Breaking Biology Technology:
(Date:11/30/2016)... -- higi SH llc (higi) announced today the launch ... industry thought-leaders and celebrity influencers looking to encourage, ... steps to live healthier, more active lives. ... built the largest self-screening health station network in ... have conducted over 185 million biometric screenings.  The ...
(Date:11/29/2016)... November 29, 2016 Nearly one billion matches per ... ... DERMALOG is ... an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint ...
(Date:11/22/2016)... According to the new market research report "Biometric System Market by ... Component (Hardware and Software), Function (Contact and Non-contact), Application, and Region - ... grow from USD 10.74 Billion in 2015 to reach USD 32.73 Billion ... Continue Reading ... ...
Breaking Biology News(10 mins):