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Synvista Therapeutics Announces Availability of Haptoglobin Genotyping Technology at The Annual Scientific Sessions of the American Heart Association
Date:11/10/2008

ur kit designed to detect Hp2-2 Diabetes, once it is cleared by the FDA, and its anticipated widespread availability bode well for its acceptance as an important tool in the detection of cardiovascular risk in diabetic patients. In turn, our test can help physicians make better treatment decisions for patients with Hp2-2 Diabetes."

At present, the haptoglobin genotype test is offered by ARUP Laboratories. A network of participating reference laboratories may forward samples to ARUP. Physicians interested in haptoglobin testing can call ARUP's 24 hour a day customer service line (800-522-2787) to obtain information on how to submit a blood sample for testing (Refer to ARUP test number 0040116).

About the Studies

In the prospective study called ICARE, 2,241 individuals with diabetes mellitus age 55 or over from 47 primary-care clinics in Israel underwent haptoglobin genotype testing and were followed for three years to track heart attack (myocardial infarction), stroke and death (cardiovascular and all cause). The study included 708 individuals with the Hp 2-2 genotype and 1,533 with one of the other two Hp genotypes (1-1 and 2-1). While baseline measurements showed no difference between the two groups in diabetes characteristics (HbA1c, duration), over the next three years, cardiovascular death was five-fold higher in the Hp 2-2 group (p=0.0001) and non-fatal MI increased by more than 50 percent (p=0.068). The differences in mortality were not affected by adjustment for diabetes characteristics or conventional cardiovascular risk factors.

The second study, another sub-study from ICARE, followed the results of tight glycemic control for a subgroup of patients during the three-year follow-up. After stratification of participants to those with an average HbA1c of above or below 7.0, results demonstrated that only those individuals who had the Hp2-2 genotype and who maintained strict glycemic control showed a reduction in the incidence of MI.
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SOURCE Synvista Therapeutics, Inc.
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