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Synthetic Biologics Responds to Recent CDC Report on Threat of "Super Bugs"
Date:9/20/2013

f drug-resistant superbugs by threat level as encouragement from the CDC that they are considering elevating the call for – and investing in – new preventative and treatment options to combat them."

About SYN-004 – Synthetic Biologics' C. diff Preventative Biologic Candidate

Synthetic Biologics' lead anti-infective biologic candidate, SYN-004, is a novel point-of-care oral enzyme prevention for C. diff, designed to be co-administered with certain IV beta-lactam antibiotics and to neutralize the antibiotics in the gastrointestinal tract, therefore protecting the balance of the microbiome. Roughly 14.4 million patients are administered "SYN-004 target" IV beta-lactam antibiotics annually3, representing an estimated target market for SYN-004 of 117.6 million beta-lactam doses purchased by U.S. hospitals3. While the final dosing regimen for SYN-004 is yet to be determined, the addressable market is extremely significant. Currently there are no approved treatments designed to protect the microbiome from the damaging effects of IV antibiotics. This worldwide opportunity could represent a potential multi-billion dollar market.

About Synthetic Biologics, Inc.

Synthetic Biologics, Inc. (NYSE MKT: SYN) is a biotechnology company focused on the development of biologics for the prevention and treatment of serious infectious diseases. The Company is developing an oral enzyme for the prevention of C. difficile infections, and a series of monoclonal antibody therapies for the treatment of Pertussis and Acinetobacter infections. In addition, the Company is developing a drug candidate for the treatment of relapsing-remitting multiple sclerosis and cognitive dysfunction in multiple sclerosis. For more information, please visit Synthetic Biologics' website at www.syntheticbiologics.com.

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5. Synthetic DNA Deemed Patentable by US Supreme Court, Gene Synthesis and Codon Optimization Provide Potential Pathway to Patentability
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