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Symphony Medical Announces First Patient Successfully Treated With Novel Congestive Heart Failure Therapy
Date:4/14/2009

rivately-held, venture-backed development stage company developing proprietary biotherapeutic products and tools to address the unmet clinical needs of millions of patients suffering from cardiac disorders. Headquartered in Orange County, California, the Company's products employ proprietary biocompatible polymers delivered into specific locations of the heart during either open chest surgery or via a minimally invasive procedure. The biopolymers are engineered to achieve clinical benefit by locally modifying cardiac physiology. Symphony's products are classified by the FDA as devices and have a clear regulatory pathway and clinical end points.

The Company has two products in its late-stage development pipeline - Algisyl-LVR(R) for the treatment to prevent or reverse the progression of chronic heart failure (CHF) and mitral valve regurgitation (MR), conditions affecting well over 5 million Americans. Symphony's approach involves implanting a space-occupying biocompatible polymer into strategic areas of the heart's left ventricle (LV) wall to affect LV shape and prevent or reverse LV enlargement. Reshaping and thickening the LV wall reduces wall stress, reduces mitral valve regurgitation and provides lasting improvement of cardiac function with an associated improvement in the patient's clinical status and quality of life. Algisyl-LVR has advanced to human clinical studies with a first-in-man study initiated in February 2009. Plexisyl-AF(R) a prophylactic method of preventing sustained post-operative atrial fibrillation (POAF), a common side effect of the approximately 1 million coronary bypass and cardiac valve replacement surgeries performed each year. Plexisyl has advanced to human clinical stage testing. A 32-patient safety study was completed in Europe in May 2008.

For more information on Symphony Medical please visit our website at www.symphonymed.com.

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