Navigation Links
Symphogen Grants Exclusive Worldwide License of Phase II Oncology Drug Candidate Sym004 to Merck KGaA
Date:9/5/2012

option."

"Sym004 further strengthens our early development pipeline by adding a product that is thought to act via a proposed synergistic mechanism of action not previously studied, but more specifically, it has the potential to become a key asset complementing our already highly successful Erbitux franchise," commented Dr. Susan Jane Herbert, Head of Global Business Development and Strategy for Merck Serono. "This collaboration once again reflects our strong commitment to fighting cancer and to providing new treatment options to patients."

Sym004 is comprised of two antibodies that are not only designed to block ligand binding, receptor activation and downstream signaling but are also thought to elicit removal of the EGFR receptors from the cancer cell surface by inducing EGFR internalization and degradation.[1]

As of July 2012, 88 patients have been treated with Sym004 in clinical trials. The adverse events from the preliminary clinical data include diarrhea, skin rash, mucosal inflammation, nausea, infusion-related reaction and hypomagnesemia. Exposure data from the patients, after weekly repeated infusions, do not indicate an anti-drug antibody response.

References

1. Pedersen MW, et al. Cancer Res 2010;70:588-97.

Conference Call

Symphogen will host a conference call today (Thursday 6 September 2012) to discuss the announcement at 11:30 CET/ 10:30 BST.

Kirsten Drejer, Symphogen's Chief Executive Officer, will host the call to discuss the licence agreement with Merck KGaA for Sym004, followed by a Q&A session. The call will be conducted in English.  Please use the following dial-in details:

Denmark: 327-276-25

International: +44(0)1452-555-566

Please quote the following Conference ID: 28172177

An accompanying presentation will be released on Symphogen's website and available for download just before the start of the call and can be
'/>"/>

SOURCE Symphogen
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. The Leukemia & Lymphoma Society Awards $12 Million in Research Grants in Four Critical Areas of Unmet Medical Need
2. USPTO Grants Butamax a Further KARI Enzyme Patent
3. Enox Biopharma, Inc. Grants TTA LTD License To Wound Care Applications
4. FDA Grants Lexicon Orphan Drug Designation for Telotristat Etiprate for the Treatment of Carcinoid Syndrome
5. Heptares Grants Shire an Exclusive Worldwide Licence to Develop and Commercialise Novel Drug Candidate for CNS Disorders
6. NSF CAREER grants support ocean energy, microforming, computer planning
7. Maryland Stem Cell Research Commission Announces New Program for Pre-Clinical and Clinical Research Grants
8. Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries
9. Free Job Training: 55 Grants Available to Retrain Workers for Biofuels Industry
10. Pinnaclife, Inc., Announces NDC, Inc., to Exclusively Distribute the New Animal Health Product Line!
11. MO BIO Laboratories, Inc. Becomes Exclusive Sponsor Of Natures Human Microbiota Special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 Sigma-Aldrich Corporation (NASDAQ: ... under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) ... 22, 2014, thereby completing the U.S. HSR Act ... of the Company by Merck KGaA, Darmstadt, Germany.  ... condition to closing the transaction, which remains subject ...
(Date:12/22/2014)... Brussels (PRWEB) December 22, 2014 The ... the global leader of technical training across the life ... Clinical Data Management (SCDM) to provide the organization's ... certification programs —providing access to the more than 350 ... SCDM members with 10% off when registering for a ...
(Date:12/22/2014)... , Dec. 22, 2014  Alternative Energy ... that it has signed a letter of intent ... has developed and patented a nanotechnology-based development platform ... products that enable rapid on-site collection and testing ... and health issues in an immediate, non-invasive and ...
(Date:12/22/2014)... December 22, 2014 The ... publication of original research, reviews and editorials addressing ... clinical practice, today published a provocative article exploring ... development, progression and potential treatment of prostate cancer. ... research and proposes the possibility that there could ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3ALNE Announces Intention To Acquire BioTechPharma 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... 26, 2011 Mylan Inc. (Nasdaq: MYL ) today ... September 30, 2011. Financial Highlights ... 30 compared to $0.43 for the same prior year period; ... September 30 compared to $1.16 for the same prior year period; ...
... Calif., Oct. 25, 2011 Life Technologies Corporation ... Dx Genetic Analyzer has been approved by China,s State Food ... Dx is a capillary-based Sanger Sequencer intended for use in ... of genetic changes that may lead to disease presence or ...
... MENLO PARK, Calif. and IPSWICH, Mass., Oct. 25, 2011 ... of products and services for studying regulatory elements in ... New England Biolabs, Inc. (NEB) to create a new ... of SwitchGear,s LightSwitch™ Luciferase Assay System and NEB,s BioLux® ...
Cached Biology Technology:Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 2Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 3Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 4Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 5Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 6Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 7Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 8Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 9Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 10Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 11Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 12Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 13Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 14Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 15Mylan's Third Quarter 2011 Adjusted Diluted EPS Increases 28% to $0.55 16Life Technologies Launches 3500 Dx Series Genetic Analyzers for In Vitro Diagnostic Use in China 2Life Technologies Launches 3500 Dx Series Genetic Analyzers for In Vitro Diagnostic Use in China 3Life Technologies Launches 3500 Dx Series Genetic Analyzers for In Vitro Diagnostic Use in China 4SwitchGear Genomics and New England Biolabs Develop New Multiplex Reporter Assay System 2
(Date:12/5/2014)... Dec. 4, 2014  Tute Genomics, a leader in ... in Series A1 funding led by UK-based Eurovestech. Peak ... in the investment round. "We are at ... adopts next-generation sequencing and seeks new approaches for the ... Robison , MD MBA, and CEO of Tute Genomics. ...
(Date:11/21/2014)... 18, 2014 According to a ... Systems (Video, RFID, Access Control, Intrusion Detection, Parking Management, ... Government), Component Service Geography - Global Forecasts to 2020", ... projected to be around $25 Billion in 2014 and ... at a CAGR of 8.69%. Browse 116 ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014   Atmel® ... leader in microcontroller (MCU) and touch technology solutions, today ... temperature sensors with the widest V cc ... higher temperature accuracy and faster I 2 C bus ... and serial EEPROM memory making them ideal for consumer, ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... This news release is available in French . ... with today,s technology, it still takes both a male and a female ... raise that child? Many studies have outlined the value of a mother, ... New findings from the Research Institute of the McGill University Health Centre ...
... Dangerous Climate Change: Required Reductions of Carbon Emissions to ... Hansen and colleagues, and announces call for papers on ... assesses climate impacts of global warming using ongoing observations ... and simple representations of the global carbon cycle and ...
... Nov. 27, 2013 The mating roar of a male ... predator. Unfortunately for the seals, scientists have found evidence that ... present their work at the 166th Meeting of the Acoustical ... San Francisco, Calif. Previous research had shown mammal-eating killer ...
Cached Biology News:Dads: How important are they? 2Assessing dangerous climate change and call for climate change response papers 2Silent stalkers of dark ocean waters 2
A Highly Purified, Cost-Effective Taq DNA Polymerase...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
... SUPERaseIn RNase Inhibitor (patent pending) is a ... noncovalently binds and inhibits the most common ... C, 1 and T1. SUPERaseIn can be ... could be problematic. It is ideal for ...
... (Chemical Inkjet Printer) is a revolutionary ... and Protein Macroarray Analysis, developed in ... The strategy compliments established protocols in ... the proteins isoelectric point and apparent ...
Biology Products: