Navigation Links
Symbiotic microbes induce profound genetic changes in their hosts
Date:7/28/2008

antage of a relatively simple host-bacterium relationship: the Hawaiian bobtail squid, a colorful critter less than two inches long that nurtures a single type of light-producing bacteria, called Vibrio fischeri. The bacteria take up residence in a specialized pouch on the squid's belly and produce light that the squid uses as anti-predator camouflage. In return, the bacteria receive easy access to nutrients from the squid.

In the new study, a team led by former UW-Madison graduate student Carlene Chun dissected the genetics of the squid host response, including a comparison with mutant bacteria unable to successfully colonize their host. They identified hundreds of genes affected by the establishment of a stable bacterial partnership, including some known to play a role in human responses to bacteria.

The involvement of several genes typically associated with responses to bacterial infection, such as members of common immune signaling pathways, suggests we may need to rethink our understanding of the main purpose of the immune system, McFall-Ngai says.

"We have thousands of bacteria that live with us, and yet there are only around 100 bacterial pathogens," she says. Given the numbers, "it seems like these pathways and these molecules are likely to be 'symbiosis' pathways more than 'anti-pathogen.'"

Her team also highlighted several genes corresponding to those previously implicated in establishing symbiotic relationships with gut bacteria in fish and mice, suggesting that the animal-bacteria conversation may be basically the same across evolution.

"All animals and plants evolved in the background of the presence of huge numbers of environmental bacteria These genes might be considered the core conserved responses of animals to interactions with bacteria" along tissue surfaces like intestine walls and skin, McFall-Ngai says. "The language is ancient and highly conserved."


'/>"/>

Contact: Margaret McFall-Ngai
mjmcfallngai@wisc.edu
608-262-2393
University of Wisconsin-Madison
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology technology :

1. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
2. Entry of Biogenerics and Decreasing Use of Amgens Epogen and Johnson & Johnsons Procrit Will Cause a $2.8 Billion Decline in the Drug Market for Chemotherapy-Induced Anemia by 2016
3. ProMetic reports continued positive data in PBI-1402 phase II trial in chemotherapy-induced anemia
4. New Therapy by Merck is Positioned to Earn Gold-Standard Status by 2011 in the Treatment of Chemotherapy-Induced Nausea and Vomiting
5. Oral PBI-1402 Demonstrates Significant Activity in Chemotherapy-Induced Anemia Phase II Clinical Trial
6. Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients
7. Two Year Study Confirms SUPPRELIN(R) LA Implant Maintains Profound Suppression of Hormones in Children With Premature Onset Puberty
8. Digital Unions RT1(TM) Software Creates Telegenetics Network for Region 3 Genetics Collaborative
9. Response Genetics Reports Second Quarter 2007 Financial Results
10. ZymoGenetics Will Hold Conference Call Today at 5:00 p.m. Eastern Time to Provide Update on rThrombin
11. Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... 23, 2013 PuraMed BioScience ® , ... of over-the-counter (OTC) medicinal and healthcare products, announced ... the company based on low market capitalization valuation. ... All Natural Product to Treat Migraine Headaches ... Prescription Competitor , Currently Available Nationwide at ...
(Date:5/23/2013)...  Saddleback Memorial Medical Center in Laguna ... on the West Coast to perform a hysterectomy using ... women with a state-of-the-art, minimally invasive approach to gynecological ... , M.D., a highly regarded Orange County ... minimally invasive surgery at Saddleback Memorial, led the surgical ...
(Date:5/23/2013)... , May 23, 2013 Northwest Biotherapeutics ... company developing DCVax ® personalized immune therapies for ... its exhibit at this year,s American Society Of Clinical ... to highlight its leadership role in immune therapy.  ... ASCO annual meeting is the pre-eminent conference focused on ...
(Date:5/23/2013)... BUSAN, South Korea , May 23, 2013 ... collaboration with SillaJen, Inc., a private biotherapeutics and ... of targeted biological products for cancer, announced today ... antibodies in patients treated with the oncolytic and ... This research was published in the ...
Breaking Biology Technology:PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3
... out that "free" services can be profitable after all. ... this month it would hit the elusive goal of ... of hooking up business contacts for free, LinkedIn last ... to $2,000 per year. Acceptance of these premium offerings ...
... big enough that no one is likely to see everything it ... during the marathon event that promises to draw around 20,000 people ... their responses: , , Sal Braico, COO of ConjuGon ... which is part of BIO. They have companies presenting and opportunities ...
... Ten $1,000 scholarships and a top prize of ... entrepreneurs in a business-plan competition sponsored by BizFilings , ... Foundation . , ,The contest, named Plan for the Future, ... May 31. They'll be judged by an independent panel. , ...
Cached Biology Technology:Free can be profitable 2Where will you be at BIO? 2
(Date:5/23/2013)... Science , Automated conserved noncoding ... promoter evolution among grasses , Within the genome ... DNA that undergo little change in position and sequence ... any proteins. Some of these evolutionarily stable sequences, so-called ... expression of other genes or the condensation of chromosomes, ...
(Date:5/23/2013)... said to be the world,s most popular fruit, can ... research with purple GM varieties. , "Working with ... by the addition of a specific compound, allows us ... said Professor Cathie Martin from the John Innes Centre. ... with better flavour, health and shelf life characteristics because ...
(Date:5/23/2013)... Wash. Pacific Northwest National Laboratory honored more ... commercialization of intellectual property at PNNL,s annual Intellectual ... , The Department of Energy national laboratory named ... for his work developing battery materials that can ... the electrical grid, and reduce the time it ...
Breaking Biology News(10 mins):Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3The world's favorite fruit only better-tasting and longer-lasting 2PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2
... Singapore,s Institute of Bioengineering and Nanotechnology (IBN) has ... unique surfactant template. This completely new porous structure ... In the current Nature Chemistry ... this novel material, named IBN-9 after the research ...
... 3 The General Services Administration (GSA) has ... provider of Personal Identity Verification (PIV) Enrollment and ... Security Presidential Directive 12 (HSPD-12). With this certification, ... 70 contract under the GSA SIN 132-62 as ...
... April 3, 2009 -- By identifying a novel compound that ... Laboratory and the University of Chicago may be on a ... in Science , a team that includes Tim Tschaplinski ... has a role in priming the immunity response in Arabidopsis, ...
Cached Biology News:First tri-continuous mesoporous Silica complex structure developed in Singapore 2ABBTECH Staffing Services Certified by GSA as an HSPD-12 Managed Service Provider 2Researchers discover primer to plant defense system 2
Request Info...
... Origami host strains are K-12 derivatives ... reductase (trxB) and glutathione reductase (gor) genes, ... the cytoplasm. Studies have shown that expression ... than in another host even though overall ...
Request Info...
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Biology Products: