Navigation Links
'Swine flu' breath test could reduce future vaccination shortages, research suggests
Date:7/14/2011

A novel breath test, measuring the immune response to the H1N1 flu virus, could help to ease future vaccine shortages by identifying the people who have already been infected with the flu virus.

In a study published today, 15 July 2011, in IOP Publishing's Journal of Breath Research, researchers have investigated an easy, non-invasive breath test to measure biomolecules that accumulate in response to the H1N1 strain.

Research published last month claimed that over half of the people in Glasgow vaccinated during the 2009 swine flu pandemic were already infected with the flu virus, meaning they were vaccinated unnecessarily. It is thought that similar patterns would have been found throughout the UK.

These vaccinations would not have harmed the people concerned, however local health authorities would have been affected as they attempted to administer the vaccine quickly and effectively on limited supplies.

A fast-acting, non-invasive test for the virus could therefore help to avoid unnecessary vaccinations and help prioritise the people who most need the vaccines.

The researchers, from Cleveland Clinic and Syft Technologies, enrolled 11 individuals on their study of which nine were given the live attenuated H1N1 vaccine and administered the breath test on each of the following seven days.

The breath test examined exhaled nitric oxide (NO) a biomolecule whose production has previously been linked to influenza and viral infection and has been speculated to play a beneficial role in viral clearance.

The results showed a peak in NO levels in all subjects on the third day after vaccination. There were no significant differences in NO levels on any other day.

Of the 11 other compounds examined in the study, only one compound isoprene - showed an elevated level, again on day three. Increased levels of isoprene, a compound produced within the body and a major constituent of exhaled breath, have been reported to reflect oxidative stress in the airways.

Previous findings show that the highest number, and severity, of symptoms related to a H1N1 infection occur on day three, suggesting, along with this research, that this is when an immune response is triggered in the body.

The H1N1 swine flu pandemic of 2009 affected over 214 countries and resulted in approximately 43󈟅 million illnesses and 8,870󈝾,449 deaths.

This study presents the first direct evidence of a potential test to diagnose H1N1 influenza using your breath, a concept which has already been used to diagnose and monitor asthma, check for transplant organ rejection, and to detect lung cancer and alcohol intoxication.

If a fast, easy, non-invasive breath test is to be mass-produced, the researchers state that further work will need to identify other compounds associated with an immune response that were only touched upon in this study, as well as identifying the exact mechanism underlying the increase in exhaled NO as a result of the live vaccine.

One of the study's authors Professor Raed Dweik said, "This study adds to the growing evidence for the utility of breath analysis in medical diagnostics. More work still needs to be done, however, to identify the specific compounds that change in response to vaccination and to find the biologic link between those compounds and the host response to the vaccine or the actual disease."


'/>"/>

Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics
Source:Eurekalert

Related biology technology :

1. Neogen Named Supplier of Chr. Hansen Probiotics for Swine and Poultry
2. Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak
3. Biotechnology Company, Replikins Ltd., Provided Advance Warning of Mexican H1N1 Swine Flu Virus Outbreak
4. CEL-SCIs L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies
5. Antiviral Drugmaker Shares Soar as Swine Flu Spreads; Beacon Equity Issues Stock Alerts on: HEB, GNBT, BCRX, DVAX, NVAX, SVA
6. Medicago initiates work on Swine Flu strain
7. MMR Offers Free Surgical Masks to Call Attention to Importance of Personal Health Records in Preparing for Possible Swine Flu Pandemic
8. Swine Flu a Reminder: Using Hand Sanitizers Like Remi-D Helps Fight Infection
9. Sinovac Initiates Preparatory Activities for Swine Flu Vaccine
10. H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide
11. First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
Breaking Biology Technology:
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):