Navigation Links
'Swine flu' breath test could reduce future vaccination shortages, research suggests

A novel breath test, measuring the immune response to the H1N1 flu virus, could help to ease future vaccine shortages by identifying the people who have already been infected with the flu virus.

In a study published today, 15 July 2011, in IOP Publishing's Journal of Breath Research, researchers have investigated an easy, non-invasive breath test to measure biomolecules that accumulate in response to the H1N1 strain.

Research published last month claimed that over half of the people in Glasgow vaccinated during the 2009 swine flu pandemic were already infected with the flu virus, meaning they were vaccinated unnecessarily. It is thought that similar patterns would have been found throughout the UK.

These vaccinations would not have harmed the people concerned, however local health authorities would have been affected as they attempted to administer the vaccine quickly and effectively on limited supplies.

A fast-acting, non-invasive test for the virus could therefore help to avoid unnecessary vaccinations and help prioritise the people who most need the vaccines.

The researchers, from Cleveland Clinic and Syft Technologies, enrolled 11 individuals on their study of which nine were given the live attenuated H1N1 vaccine and administered the breath test on each of the following seven days.

The breath test examined exhaled nitric oxide (NO) a biomolecule whose production has previously been linked to influenza and viral infection and has been speculated to play a beneficial role in viral clearance.

The results showed a peak in NO levels in all subjects on the third day after vaccination. There were no significant differences in NO levels on any other day.

Of the 11 other compounds examined in the study, only one compound isoprene - showed an elevated level, again on day three. Increased levels of isoprene, a compound produced within the body and a major constituent of exhaled breath, have been reported to reflect oxidative stress in the airways.

Previous findings show that the highest number, and severity, of symptoms related to a H1N1 infection occur on day three, suggesting, along with this research, that this is when an immune response is triggered in the body.

The H1N1 swine flu pandemic of 2009 affected over 214 countries and resulted in approximately 43󈟅 million illnesses and 8,870󈝾,449 deaths.

This study presents the first direct evidence of a potential test to diagnose H1N1 influenza using your breath, a concept which has already been used to diagnose and monitor asthma, check for transplant organ rejection, and to detect lung cancer and alcohol intoxication.

If a fast, easy, non-invasive breath test is to be mass-produced, the researchers state that further work will need to identify other compounds associated with an immune response that were only touched upon in this study, as well as identifying the exact mechanism underlying the increase in exhaled NO as a result of the live vaccine.

One of the study's authors Professor Raed Dweik said, "This study adds to the growing evidence for the utility of breath analysis in medical diagnostics. More work still needs to be done, however, to identify the specific compounds that change in response to vaccination and to find the biologic link between those compounds and the host response to the vaccine or the actual disease."


Contact: Michael Bishop
Institute of Physics

Related biology technology :

1. Neogen Named Supplier of Chr. Hansen Probiotics for Swine and Poultry
2. Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak
3. Biotechnology Company, Replikins Ltd., Provided Advance Warning of Mexican H1N1 Swine Flu Virus Outbreak
4. CEL-SCIs L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies
5. Antiviral Drugmaker Shares Soar as Swine Flu Spreads; Beacon Equity Issues Stock Alerts on: HEB, GNBT, BCRX, DVAX, NVAX, SVA
6. Medicago initiates work on Swine Flu strain
7. MMR Offers Free Surgical Masks to Call Attention to Importance of Personal Health Records in Preparing for Possible Swine Flu Pandemic
8. Swine Flu a Reminder: Using Hand Sanitizers Like Remi-D Helps Fight Infection
9. Sinovac Initiates Preparatory Activities for Swine Flu Vaccine
10. H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide
11. First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide
Post Your Comments:
(Date:11/24/2015)... India , November 24, 2015 ... a new market research report "Oligonucleotide Synthesis Market by ... Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, ... 2020", published by MarketsandMarkets, the market is expected to ... Million in 2015, at a CAGR of 10.1% during ...
(Date:11/24/2015)... 24, 2015 SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: ... 11,000 post-share consolidation (or 1,100,000 pre-share consolidation) Series ... Warrants") subject to the previously disclosed November 1, ... which will result in the issuance of 365,518 ... issuance of such shares, there will be approximately ...
(Date:11/24/2015)... ... ... InSphero AG, the leading supplier of easy-to-use solutions for production, culture, and ... as Chief Operating Officer. , Having joined InSphero in November 2013 as ... promoted to Head of InSphero Diagnostics in 2014. There she has built up ...
Breaking Biology Technology:
(Date:11/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), the leading ... into the automotive market with a comprehensive and dedicated ... consumer electronics human interface innovation. Synaptics, industry-leading touch controllers, ... automotive industry and will be implemented in numerous locations ... , Japan , and ...
(Date:10/29/2015)... Oct. 29, 2015  The J. Craig Venter Institute ... "DNA Synthesis and Biosecurity: Lessons Learned and Options for ... Health and Human Services guidance for synthetic biology providers ... --> --> Synthetic ... the potential to pose unique biosecurity threats. It now ...
(Date:10/29/2015)... NXTD ) ("NXT-ID" or ... the growing mobile commerce market and creator of ... leading marketplace to discover and buy innovative technology ... on StackSocial for this holiday season.   ... a biometric authentication company focused on the growing ...
Breaking Biology News(10 mins):