Susan G. Komen for the Cure(R) Announces Largest Grants Slate Ever: $100 Million to Speed Delivery of Breast Cancer Discover...(/ -- A 2007 Komen for the Cure grant...)

-- A 2007 Komen for the Cure grant was awarded to Insoo Bae, Ph.D., of

Georgetown University to identify environmental agents that cause DNA

damage to BRCA1 defective breast cells, triggering the development of

cancerous tumors.

-- A Komen for the Cure grant is supporting the work of

Amy Trenthan-Dietz, Ph.D., of the University of Wisconsin-Madison as

she focuses on whether human exposure to a large number of chemicals

in the environment with estrogenic properties (called 'xenoestrogens')

is sufficient enough to increase breast cancer risk.

Dr. Trenthan-Dietz is making use of a new technique to measure total

xenoestrogen exposure burden -- the sum of estrogenic activity of all

xenoestrogens to when an individual is exposed. Findings could prove

instrumental in helping public health officials identify and target

potential sources of exposure.

-- Dr. Donald Lannin of Yale University is using Komen grant money to

study the intricacies of ductal carcinoma in situ (DCIS) in order to

determine more clearly which cases are likely to become invasive.

-- Komen for the Cure is enabling Dr. Michael A. Tainsky of Wayne State

University in Michigan to test a unique combination of techniques for

cancer detection, including robotics and computer-based informatics to

identify hundreds of potential biomarkers specific to DCIS and

determine which cases may become invasive.

-- A Komen for the Cure grant to support the development of experimental

model systems is helping Dr. Celeste Nelson at Princeton University to

develop a three-dimensional microlithography-based model system to

study what happens in and around breast cells as they undergo

malignant transformation. Looking at complex chains of events and

cellular cros
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