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Superior Efficacy-dose Ratio for Lantus(R) Over detemir
Date:9/30/2009

as similar with Lantus(R) and insulin detemir (-1.46 plus or minus1.09 and -1.54 plus or minus 1.11%; p=0.149), endpoint HbA1c levels were 7.2 plus or minus 0.9% and 7.1 plus or minus 0.9% respectively. Endpoint FBG was lower with Lantus(R) versus insulin detemir (108 plus or minus 24 vs 119 plus or minus 32mg/dL).

There was a lower rate of daytime symptomatic hypoglycaemia confirmed by PG less than or equal to 56 mg/dL (3.1 mmol/L) with Lantus(R) treatment vs. insulin detemir (1.06 plus or minus 3.13 vs. 1.64 plus or minus 5.42 events/patients-year, p=0.046). Frequencies of asymptomatic, overall symptomatic, nocturnal symptomatic and severe hypoglycaemia were comparable between treatment groups. Significantly more patients in the insulin detemir group terminated the study early (10.1 vs. 4.6%, p=0.001), which was mostly related to skin reactions. Limited weight gain in both groups, although compared with the glargine group, patients on insulin detemir experienced less weight gain (0.6 versus 1.4kg, difference 0.77kg p<0.001).

About Lantus(R)

Lantus(R) is indicated for once-daily subcutaneous administration in the treatment of adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycaemia and for adult and paediatric patients (6 years and older) with type 1 diabetes mellitus. Lantus(R) demonstrates a peakless and sustained concentration/time profile over 24h thus reducing the risk of hypoglycaemia and allowing a constant and high efficacy over 24h with one single day injection. Lantus(R) is the number one prescribed insulin worldwide.

About Diabetes

Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this num
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SOURCE Sanofi Aventis Groupe
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