Navigation Links
SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy
Date:10/23/2008

DUBLIN, Calif., Oct. 23 /PRNewswire-FirstCall/ -- SuperGen, Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery and development of novel cancer therapies, today presented data on MP-470, its lead product candidate, and four additional posters, at the 20th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics" in Geneva, Switzerland. MP-470, an orally bio-available multi-targeted tyrosine kinase inhibitor, showed encouraging tumor regression results in the first two arms (paclitaxel/carboplatin and carboplatin/etoposide) of its current Phase 1b clinical trial examining MP-470 combined with five standard of care (SOC) anticancer treatments.

"We are extremely pleased to report a series of important clinical and scientific advances achieved by our Company," said James S. Manuso, Ph.D., SuperGen's President and Chief Executive Officer. "In addition to MP-470's progress in the clinic, before year-end, we expect to enter SGI-1776, our PIM kinase inhibitor, into Phase 1 clinical trials. This will be our second novel drug in clinical development."

In a poster presentation (Abstract #403) entitled, "Clinical responses of highly refractory solid tumor patients to oral MP-470, a multi-targeted tyrosine kinase inhibitor, in combination with standard of care chemotherapy regimens. Preliminary report from a multi-institutional phase 1b clinical trial," Dr. A. Tolcher, Director of Clinical Research at START (South Texas Accelerated Research Therapeutics) in San Antonio, Texas, highlighted data showing tumor regression in four patients in the two arms, indicating that MP-470 may sensitize/re-sensitize tumors to the anticancer effects of SOC regimens of DNA-damaging agents. Of note, MP-470 did not increase the types or severity of adverse events. However, a primary endpoint of the trial - determining the maximum tolerated dose of MP-470 co-administered with SOC regimens - has not been reached and dose escalation continues.

"These compelling results strengthen the rationale for combining MP-470 with DNA-damaging agents due to MP-470's purported ability to suppress the Rad51 DNA repair mechanism, which is important in various malignancies," said Dr. Gregory Berk, SuperGen's Chief Medical Officer. "We look forward to presenting updated results on MP-470 in combination with these platinum doublets, as well as the other three standard of care arms of the trial in the future."

Earlier this year, U.S. Food and Drug Administration granted orphan drug designation for MP-470 in the treatment of glioblastoma multiforme (GBM) after non-clinical studies showed more than two-fold effect of increased cell death when used synergistically with ionizing radiation. Orphan drug designation for GBM, an often fatal form of brain cancer, can entitle SuperGen to seven years of market exclusivity. SuperGen's lead product candidate has also shown promise in preclinical testing across a wide spectrum of cancers, including non-small cell lung cancer.

Furthermore, SuperGen presented four additional posters at the Symposium that reviewed clinical and non-clinical advances of the compounds MP-470, SGI-1776 and SGI-1252. These include:

Abstract 332: In vivo activity of SGI-1776, an orally active PIM kinase

inhibitor

Abstract 426: Effects of food on the single-dose pharmacokinetics of oral

MP-470 capsules

Abstract 480: MP-470, a novel multi-targeted tyrosine kinase inhibitor

targeting Rad51 is not toxic to human primary marrow stem cells at

clinically relevant concentrations

Abstract 571: Modulation of JAK2 signaling pathways in vitro and in vivo

Copies of the 20th EORTC-NCI-AACR Symposium poster presentations will be available in the pipeline section of SuperGen's Web site http://www.supergen.com.

About SuperGen

Based in Dublin, Calif., SuperGen, Inc. is a pharmaceutical company dedicated to the discovery and development of novel cancer therapies. SuperGen is developing a number of therapeutic anticancer products focused on kinase and cell signaling inhibitors and DNA methyltransferase inhibitors. For more information about SuperGen, please visit http://www.supergen.com.

Forward-Looking Statements

This news release contains certain "forward-looking" statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are typically preceded by words such as "believes," "expects," "anticipate," "intends," "will," "may," "should," or similar expressions. These forward-looking statements are not guarantees of future performance and involve a number of risks and uncertainties that may cause actual results to differ materially from the results discussed in these statements. Factors that might cause the company's results to differ materially from those expressed or implied by such forward-looking statements include, but are not limited to, the ability to discover, develop and move target compounds into clinical development and other risks and uncertainties detailed from time to time in the company's filings with the Securities and Exchange Commission including its most recently filed Form 10-Q and 10-K. SuperGen, Inc. undertakes no duty to update any of these forward-looking statements to conform them to actual results.

Contacts:

SuperGen, Inc. Dorland Global Public Relations

Timothy L. Enns Michael Beckerich (Media)

SVP, Corporate Communications Tel: (212) 677-7632

& Business Development mbeckerich@dorland.com

Tel: (925) 560-0100

Email: tenns@supergen.com

Mary M. Vegh

Manager, Investor Relations

Tel: (925) 560-2845

E-mail: mary.vegh@supergen.com


'/>"/>
SOURCE SuperGen, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. SAFC Hitech(TM) Successfully Demonstrates Device-Quality GST Precursors For Phase Change Memory Applications
2. Grid Dynamics Demonstrates Linear Scalability up to 512 Nodes with GridGain Software on Amazon EC2 Cloud
3. First semiconductor-based PET scanner demonstrates potential to aid in early diagnosis of disease
4. SemBioSys Demonstrates Functionality of its Safflower Produced Apo AI(Milano)
5. ASCO 2008: Tumor-Targeted Rexin-G Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Metastatic Pancreatic Cancer
6. Oral PBI-1402 Demonstrates Significant Activity in Chemotherapy-Induced Anemia Phase II Clinical Trial
7. ANX-530 Demonstrates Equivalent Pharmacokinetics to Navelbine(R) in a Registrational Bioequivalence Clinical Study
8. Bringing a New Rhythm to Cardiology Workflow: Siemens Demonstrates Answers to Cardiologys Toughest Questions
9. 960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotechs Novel 5-FU Central Venous Catheter
10. USGI Medical Demonstrates First System for Gastrotomy Closure in NOTES
11. Job-related stress: NIST demonstrates fatigue effects in silicon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
Breaking Biology Technology:
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
Breaking Biology News(10 mins):