Navigation Links
SuperGen Reports 2008 Second Quarter Financial Results
Date:8/4/2008

ion

in vitro. SGI-1776 induced significant tumor regression in MV-4-11

(AML) and MOLM-13 (AML) xenograft models.

-- MP-470, an early clinical-stage multi-targeted tyrosine kinase

inhibitor and Rad51 suppressor, was shown to be bioavailable and

well-tolerated in a first in human study (Abstract No. 4083). The

presentation entitled, "MP-470, a potent oral Rad51 suppressor is

safe and tolerable in first-in-human study," summarized the data

suggesting that MP-470 is well-tolerated when administered in doses

of up to 900 mg per day. Additionally, it was found that Rad51

expression is modulated in a dose-dependent manner. This is

consistent with pre-clinical studies where MP-470 was shown to

sensitize cancer cells to DNA damaging agents and radiation therapy

by suppressing Rad51, a protein responsible for repair of double

strand DNA breaks in cancer cells.

-- MP-470 was shown to effectively sensitize prostate and breast cancer

cells to erlotinib (Abstract No. 671). The presentation entitled,

"Inhibition of erlotinib resistance on HER-family tyrosine kinases

by combination with MP-470, a multi-targeted TK inhibitor in

prostate and breast cancer," highlighted data suggesting that the

combination of MP-470 and erlotinib inhibits the binding of the p85

subunit of PI3K. The poster outlined the enhanced impact of the

combination of MP-470 and erlotinib, compared to either agent alone

in reducing phosphorylation of Akt, ERK1/2, EGFR/HER1, HER2/Neu, and

HER3.

-- S-110, a DNA methyltransferase inhibitor, demonstrated an improved

in vivo activity profile over decitabine (Abstract No. 2613). The

presentation entitled, "Decitabine administered as a Dinucleotide'/>"/>

SOURCE SuperGen, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Dr. Audrey F. Jakubowski of SuperGen Retires as Chief Regulatory and Quality Officer
2. SuperGen to Present at Thomas Weisel Partners Healthcare Conference September 5th
3. SuperGen to Announce 2007 Fourth Quarter and Fiscal Year-End Financial Results March 3, 2008
4. SuperGen Reports 2007 Fourth Quarter and Annual Financial Results
5. SuperGen to Announce 2008 First Quarter Financial Results April 28, 2008
6. SuperGen to Webcast 3rd Annual Analyst Day on April 29, 2008
7. SuperGen Reports 2008 First Quarter Financial Results
8. SuperGen to Present at FBR Capital Markets 12th Annual Spring Investor Conference on May 29, 2008
9. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
10. QMed, Inc. Reports July Medicare SNP Enrollments
11. Phlo Affiliate Reports Expanded Coverage to Oregon Border
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... More than 5 million Americans are currently ... seniors will die with Alzheimer’s or another dementia, according ... shocked many Americans into looking for ways to improve ... age-related cognitive disorders. Jonathan Weisman, president of Biohack Pure, ...
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Inc. (NYSE Amex: PIP ) announced today ... its recombinant protective antigen (rPA) anthrax vaccine program.  PharmAthene ... process for the bulk drug substance of its vaccine ... US-based manufacturing facility at Diosynth RTP.   Activities to ...
... 2011 Caliper Life Sciences, Inc. (NASDAQ: ... Inc., an innovative sequencing service provider based in Gaithersburg, ... the 5500xl, SOLiD 4, and Ion Torrent Personal Genome ... will initially focus on sample preparation for exome, whole ...
... June 27, 2011 ,   ReportsnReports ... , Report in its store Browse the complete ... Report now! Search 75000+ Market Research,Reports ... Reports Report Summary Eliminate unnecessary ...
Cached Biology Technology:PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer 2PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer 3EdgeBio Selects Caliper's Sample Preparation Suite for High Throughput and Benchtop Sequencing Workflows 2ReportsnReports - Daptomycin - Comprehensive Patent Search 2ReportsnReports - Daptomycin - Comprehensive Patent Search 3ReportsnReports - Daptomycin - Comprehensive Patent Search 4ReportsnReports - Daptomycin - Comprehensive Patent Search 5
(Date:4/23/2014)... mammals, ravens form different types of social relationships ... also form strict dominance relations. From a cognitive perspective, ... ability in daily social life ("knowing who is nice ... have with each other sets the stage for "political" ... this study have been published in the scientific journal ...
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
(Date:4/22/2014)... secret to get your child to behave at the dinner ... Cornell study published in Eating Behaviors , found that ... bite with their front teeth such as drumsticks, whole apples, ... when these foods had been cut. "They were twice ... other kids," said Brian Wansink, Professor and Director of the ...
Breaking Biology News(10 mins):Ravens understand the relations among others 2Biting vs. chewing 2
... Animals that seem identical may belong to completely different species. ... Gothenburg, Sweden, who have used DNA analyses to discover that ... types of worm. The result is one of many suggesting ... considerably larger than we thought. ,"We could be talking about ...
... the University of Leeds have developed chemicals which kill ... including those resistant to existing drugs. , ... (DHODH) - essential to the growth of the parasite ... Says lead researcher Dr Glenn McConkey, from Leeds, Faculty ...
... Maine, government scientists have figured out how to measure snowfall ... the sun - all the while saving money, energy, and, ... energy-efficient ingenuity was the need to help the National Weather ... snowmelt. The problem was this: While the USGS has ...
Cached Biology News:Animals that seem identical may be completely different species 2New hope for advances in treating malaria 2Measuring snow with a bucket, a windmill, and the sun? 2
... polyclonal antibody raised against a ... Immunogen: K6HF (NP_004684, ... partial recombinant protein with GST ... Number: NM_004693 ...
... The binding specificity and signaling of the ... to be modified by alternative splicing--which has ... SpliceArrays you can perform a classical expression ... the different alternatively spliced forms of the ...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
...
Biology Products: