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SuperGen Reports 2008 First Quarter Financial Results

erlotinib resistance on HER-family tyrosine kinases

by combination with MP-470, a multi-targeted TK inhibitor in

prostate and breast cancer," highlighted data indicating that the

combination of MP-470 and erlotinib inhibits the binding of the p85

subunit of PI3K. The poster outlined the enhanced impact of the

combination of MP-470 and erlotinib, compared to either agent alone

in reducing phosphorylation of Akt, ERK1/2, EGFR/HER1, HER2/Neu, and


-- S-110, a DNA methyltransferase inhibitor, demonstrated an improved

in vivo efficacy profile over decitabine (Abstract No. 2613). The

presentation entitled, "Decitabine administered as a Dinucleotide

prodrug increases its in vivo efficacy due to enhanced drug delivery

and stability," highlighted data indicating that S-110 showed robust

anti-tumor activity in prostate and cisplatin-resistant ovarian

carcinoma xenograft models. Additionally, S-110 restored sensitivity

to cisplatin in the ovarian cancer model. Reduced toxicity was

observed along with an increased half-life compared to decitabine.

Conference Call Information

SuperGen will host a conference call to discuss the results of the 2008 first quarter financial results today at 1:30 p.m. PT / 4:30 p.m. ET. A live webcast of the conference call is accessible via the investor relations section of the Company's web site at A webcast replay of the conference call will be available for 90 days.

About SuperGen

Based in Dublin, California, SuperGen, Inc. is a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies. SuperGen is developing a number of therapeutic anticancer products focused

SOURCE SuperGen Inc.
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