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SuperGen Reports 2007 Fourth Quarter and Annual Financial Results
Date:3/3/2008

compound, S110, activates an

important fetal hemoglobin biomarker in baboons, confirming the

product's ability to activate a specific silenced gene (Abstract 571).

An oral presentation by Donald Lavelle, Ph.D., of the University of

Illinois at Chicago, provided evidence that S110 increases fetal

hemoglobin and decreases DNA methylation in non-human primates and

cultured human erythroid progenitor cells (Poster 779). Finally the

prevention of cancer cell proliferation in non-clinical models, by the

Company's lead JAK2 kinase inhibitors was presented (Abstract 3560).

-- The Company announced that investigators dosed the first patient in a

multi-arm Phase 1b clinical trial of MP470, a novel, oral, multi-

targeted tyrosine kinase inhibitor (TKI). The trial will evaluate MP470

in combination with several standard of care chemotherapy regimens,

including carboplatin/paclitaxel, carboplatin/etoposide, docetaxel,

topotecan, and erlotinib. The trial is expected to enroll up to 105

patients at five study centers. The Phase 1b trial is an open label,

dose-escalation study designed to assess the safety and tolerability of

MP470 in combination with these standard of care chemotherapy regimens,

and to define the dose of MP470 to advance into Phase 2 combination

studies. Additionally, the Company will assess pharmacokinetic and

biomarker data from the study. The trial is open to chemotherapy naive

or treatment experienced patients with a variety of solid tumors

irrespective of previous lines of therapy.

Conference Call Information

SuperGen will host a conference call to discuss the results of the 2007 fourth quarter and annual financial results today at 1:30 p.m. PT / 4:30 p.m. ET. A live webcast of the conference call is accessible via the investor relations section of
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SOURCE SuperGen Inc.
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