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SuperGen Reports 2007 Fourth Quarter and Annual Financial Results
Date:3/3/2008

I-EORTC

International Conference, the Company announced the following: MP470, a

clinical-stage multi-targeted tyrosine kinase inhibitor, demonstrates

preclinical synergy with DNA damaging agents (Poster A173, Abstract

1026); S110, a decitabine-derived DNA demethylating agent, shows

improved pre-clinical activity due to increased drug delivery and

stability (Poster 140, Abstract 1038); and, the proprietary CLIMB(TM)

technology was successful in the lead development and design of small

molecule JAK2 and Pim kinase inhibitors (Posters C200, Abstract 907 and

C208, Abstract 985). Also, Dr. Peter A. Jones, Director of USC's Norris

Cancer Center, further discussed S110 in a plenary session on cancer

epigenetics.

-- The Company announced during an oral presentation at the American

Society for Therapeutic Radiology and Oncology's 49th Annual Meeting in

Los Angeles that MP470, a clinical-stage multi-targeted tyrosine kinase

inhibitor, is cytotoxic to glioblastoma multiforme cell lines (Abstract

178). Activity was also demonstrated in vivo in a glioblastoma

multiforme xenograft model. Evidence presented suggests that MP470

inhibits DNA damage repair through suppression of a critical DNA repair

protein, Rad51. Dr. James Welsh of the University of Arizona, who

conducted these pre-clinical studies, also revealed that the pre-

clinical activity of MP470 against glioblastoma multiforme cells is

synergistic with radiation.

December 2007:

-- As part of a series of presentations at the American Society of

Hematology's 49th Annual Meeting, the Company described how its

proprietary CLIMB technology was used in lead development and design of

small molecule Pim kinase inhibitors (Poster 845, Abstract 2655) and

how its novel decitabine dinucleotide
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SOURCE SuperGen Inc.
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