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Summary Letter to Hadasit Bio-Holdings Ltd. Shareholders
Date:10/26/2011

a peptide-based drug for the treatment of strokes, myocardial infarction, pulmonary embolism, and venous infarction – conditions that have large target markets evaluated at billions of dollars per year.  The drug is based on the research of Prof. Abd Higazi, from Hadassah Hospital and the University of Pennsylvania. In June 2011, Thrombotech announced the start of a Phase II trial in Israel and the plans to expand the trial to some six additional sites in Israel and around the world. A regulatory permit from India has been granted and the beginning of the trial in other Israeli sites in Europe and the US is expected in Q1 of 2012.

ProtAb Ltd.

ProtAb is focused on the development of drugs for the treatment of Rheumatoid Arthritis and other autoimmune diseases. The drug is based on research by Prof. Yaakov Naparstek, the Head of Internal Medicine at Hadassah Hospital.  After successfully producing humanized antibodies, the company is in the final stages of drug scale-up under GMP conditions, and is in preparation for Phase I/II clinical trials -- which are expected to commence at the beginning of 2012.

Enlivex Ltd.

Enlivex is developing cell therapy for autoimmune diseases, and is currently nearing the end of a Phase I/II clinical trial. From initial findings received from treatment groups, the treatment seems to be safe and effective in reducing graft-versus-host disease (GVHD) in patients receiving bone marrow transplants. The company believes that it can receive approval from the FDA for orphan drug recognition, a status that permits the speeding up of regulatory procedures and provides commercial advantages. There are ongoing negotiations with potential partners – financial and scientific alike.  

BioMarCare Technologies Ltd.

BioMarCare Technologies announced the receipt of a prestigious grant from the BIRD Fund ($900,000) for the support of a joint proj
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SOURCE Hadasit Bio-Holdings Ltd.
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