Navigation Links
Successful Phase I/II Clinical Trial Results From Cancer Patients Treated With Anti-Cancer Drug From Axelar AB
Date:5/6/2009

STOCKHOLM, May 6 /PRNewswire/ -- Axelar AB today announced successful completion of the single-day oral dosing part of its ongoing phase I/II clinical trial on cancer patients with its new anti-cancer drug AXL1717,an insulin-like growth factor-1 (IGF-1) receptor inhibitor which has no effects on the closely related insulin receptor. The study is conducted in Sweden on patients having terminal cancer disease. The results showed that a single-day dosing of AXL1717 could be successfully escalated with excellent tolerability. No dose-limiting toxicity was reported. The next part of the trial has now been approved, including a seven-day dosing BID regimen instead of single-day BID treatments. The first patients have already been treated with AXL1717 for seven days.

The ongoing phase I/II clinical trial is primarily designed to assess the safety, tolerability, and pharmacokinetics of the drug. As a secondary objective, anti-cancer effects are documented whenever possible.

"We are very pleased that high doses of AXL1717 could be administered to patients without significant side effects during the single-day treatments.", says Johan Harmenberg, CEO of Axelar AB. "Targeting cancer cells with AXL1717 instead of conventional cytotoxic chemotherapy may be a new and well-tolerated treatment alternative for cancer patients in the future."

The IGF-1 receptor is a promising target for the treatment of cancer, since the receptor is crucial for the survival and growth of malignant cells. In contrast, the IGF-1 receptor is not absolutely necessary for growth of normal cells.

AXL1717 is a small-molecule IGF-1 receptor inhibitor with no effect on the important and almost identical insulin receptor. Pre-clinical data show an extraordinary anti-tumor efficacy in animal models, including apparent complete tumor regression, for a wide range of human cancers such as breast cancer, prostate cancer, malig
'/>"/>

SOURCE Karolinska Development AB
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Symphony Medical Announces First Patient Successfully Treated With Novel Congestive Heart Failure Therapy
2. Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals
3. VeraSun Energy Selects Valero as Successful Bidder for Seven Facilities
4. Bavarian Nordic Has Essentially Agreed a Pathway for the Licensure of IMVAMUNE(R) With the FDA After Successful End of Phase II Meeting
5. EnWave Successfully Commercializes nutraREV(TM) Food Dehydration Technology
6. Endo Pharmaceuticals Successfully Completes Tender Offer for Shares of Indevus Pharmaceuticals and Announces Subsequent Offering Period
7. DiFUSION Technologies Completes Successful Testing of Antimicrobial Spinal Implant
8. WaferGens SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program
9. GlaxoSmithKline Successfully Completes Tender Offer for Shares of Genelabs Technologies, Inc.
10. Star Scientific Announces Successful Completion of Product Satisfaction Study - Results Show Potential for Development and Manufacturing of New Pharmaceutical Product for Smoking and Smokeless Tobacco Cessation
11. Strativa Pharmaceuticals Announces Successful Completion of Bioequivalence Studies for Ondansetron Thin Film
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... The  PROPEL Center  of the  iBIO Institute , dedicated ... life sciences companies in Illinois , ... help Illinois entrepreneurs attend ... Chicago .   AdvaMed 2014 is ... , bringing more than 1,000 companies together in ...
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
(Date:7/31/2014)... , July 31, 2014 Today BioSpace , the leading ... map campaign spotlighting the life sciences community in Illinois ... Kansas , Michigan , ... , Ohio and Wisconsin . ... 11 percent of all job postings on BioSpace originating in this region ...
(Date:7/31/2014)... at Johns Hopkins have mapped the sound-processing part of ... the proverbial forest and the trees in view. Their ... of brain activity within mice, and it enabled the ... "called" to each other. The results, which represent a ... language, appear online July 31 the journal Neuron ...
Breaking Biology Technology:iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Midwest Biotech Leaders Featured On BioSpace Map 2New mapping approach lets scientists zoom in and out as the brain processes sound 2
... Dec. 12 An Ohio-based company has,successfully grown ... soybeans,with significantly lower levels of harmful radioactive carbon-14 ... with safer, low radiocarbon,LifeBlocks(TM) foods will suffer tens ... By reducing genetic damage, risks of cancer and ...
... Osteotech, Inc.,(Nasdaq: OSTE ), a leader in ... today that its Board of Directors has,authorized a stock ... common stock may be acquired. Stock repurchases may ... through open-market and privately,negotiated transactions in such amounts as ...
... RADNOR, Pa., Dec. 11 The following statement was issued today ... , , Notice is hereby given that ... for the Southern District of New York on behalf of purchasers of ... or the "Company") between May 21, 2007 and October 21, 2008, inclusive ...
Cached Biology Technology:World's First Low Radiocarbon Food May Reduce Risks of Cancer and Birth Defects, and Possibly Even Slow the Aging Process 2Osteotech Announces Stock Repurchase Program 2Shareholder Class Action Filed Against Elan Corporation, plc by the Law Firm of Barroway Topaz Kessler Meltzer & Check, LLP 2
(Date:7/31/2014)... identify and treat those with fibromuscular dysplasia (FMD). FMD ... arteries in the body, which can restrict blood flow to ... report appearing in August 2014 issue of The ... may not be limited to the arteries as currently believed. ... and joints, as well as evidence that inflammation may be ...
(Date:7/31/2014)... Rim Fire was in full fury, raging swiftly from ... the backcountry of Yosemite National Park in California,s Sierra ... the battle began to turn, enacting a case study ... to fuel large, severe fires. , "When the Rim ... fire had been used as a management tool, rather ...
(Date:7/31/2014)... Most people are familiar with Hibiscus flowers- they ... where they are commonly planted in the landscape. ... - are endangered species. , Only a relatively ... aware of an equally beautiful and intriguing related ... literally "brother of Hibiscus". , Brother of Hibiscus ...
Breaking Biology News(10 mins):Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 3The Rim Fire 1 year later: A natural experiment in fire ecology and management 4The Rim Fire 1 year later: A natural experiment in fire ecology and management 5Brother of Hibiscus is found alive and well on Maui 2
... researchers have devised a way to use a brief burst ... gold launch pad. The technique could someday be used to ... implanted in the body. The method also may be useful ... small quantities of a material. , The technique was described ...
... the Neanderthal genome, scientists suggest an early human-Neanderthal split. ... authors, but do not share much else after evolving ... issue of Science, also finds no evidence of genetic ... to explain the evolutionary relationship between Homo sapiens and ...
... DNA may not hold the key to your origins ... access journal BMC Biology reveals that fewer than 10% ... matched to mitochondrial DNA from one single African ethnic ... use of mitochondrial DNA to trace maternal ancestries, and ...
Cached Biology News:Electric jolt triggers release of biomolecules, nanoparticles 2Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals 2Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals 3
... Polyclonal Antibody Description: ... polyclonal antibody. Detects 70 kDa YAP ... blotting and immunohistochemistry. ... Storage: -20C ...
Rabbit polyclonal to QKI...
Mouse polyclonal antibody to QPRT - quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))...
... ammonium sulfate are compatible with thermostable enzymes ... and AmpliThem™™ DNA polymerases. You can significantly ... one experiment by adding your own enzyme, ... supplied with the kit. This capability is ...
Biology Products: