Navigation Links
Study puts troubling traits of H7N9 avian flu virus on display
Date:7/13/2013

MADISON, Wis. The emerging H7N9 avian influenza virus responsible for at least 37 deaths in China has qualities that could potentially spark a global outbreak of flu, according to a new study published today (July 10, 2013) in the journal Nature.

An international team led by Yoshihiro Kawaoka of the University of Wisconsin-Madison and the University of Tokyo conducted a comprehensive analysis of two of the first human isolates of the virus from patients in China. Their efforts revealed the H7N9 virus's ability to infect and replicate in several species of mammals, including ferrets and monkeys, and to transmit in ferrets data that suggests H7N9 viruses have the potential to become a worldwide threat to human health.

"H7N9 viruses have several features typically associated with human influenza viruses and therefore possess pandemic potential and need to be monitored closely," says Kawaoka, one of the world's leading experts on avian flu.

Normally, avian influenza viruses do not infect humans, with the exception of the highly pathogenic H5N1 strains. However, the H7N9 virus has so far infected at least 132 humans, killing more than 20 percent of those infected, and several instances of human-to-human infection are suspected.

The new study suggests that the ability of the H7N9 virus to infect and replicate in human cells may be due to just a few amino acid changes in the genetic sequence of the virus. "These two features are necessary, although not sufficient, to cause a pandemic," says Kawaoka, explaining that the influenza virus depends on host cells, which it hijacks to make new virus particles and sustain the chain of infection.

In monkeys, the H7N9 virus was shown to efficiently infect cells in both the upper and lower respiratory tract. Conventional human flu viruses are typically restricted to the upper airway of infected nonhuman primates.

"If H7N9 viruses acquire the ability to transmit ef
'/>"/>

Contact: Yoshihiro Kawaoka
kawaokay@svm.vetmed.wisc.edu
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology technology :

1. DOs and DON’Ts of Study Start-Up: Best Practices to Improve Efficiency and Meet/Exceed Timelines, New Life Science Webinar Hosted by Xtalks
2. Study Scavenger and JALR.org Announce Alliance Utilizing Smart Phone Capabilities to Bring Clinical Trials to Motivated Subjects
3. New Approaches in Immunogenicity Assessment Using the New SQiDlite™ System: Case Study Analysis, New Life Science Webinar Hosted by Xtalks
4. New Study Reveals that PEEK Polymer Spinal Cage Is Superior to Titanium in Surgical Treatment of Multilevel Cervical Spondylotic Myelopathy
5. Americord Applauds Study on Stem Cell Therapy for Congenital Heart Defects
6. Study Data Tabulation Model in Real Time, New Webinar Hosted by Xtalks
7. RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants
8. Lilly and Incyte Announce Baricitinib Efficacy and Safety Data from the Open-Label, Long-Term Extension of the Phase 2b JADA Study in Patients with Rheumatoid Arthritis
9. Are Root Canals Headed for Obscurity? Stem Cell Study Indicates Maybe So
10. Adult Acne Treatment Explains a New Upcoming Study that may Change the Acne Treatment Industry
11. Ambit Announces Presentation of Results from Phase 2 ACE Study of Quizartinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) at the Annual Meeting of the American Society of Clinical Oncology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... , 17 de septiembre de 2014 /PRNewswire/ ... principal proveedor mundial de soluciones logísticas avanzadas ... de la vida, anunció hoy la contratación ... global con sede en Rótterdam, Países Bajos, ... clientes Europa en rápido crecimiento. Según los ...
(Date:9/17/2014)... 2014 First antibacterial ... a truly novel class of anti-infective in ... a biopharmaceutical company developing a truly novel ... has secured £4.0m ($6.4m) to advance the ... a range of Gram-positive infections including  Clostridium ...
(Date:9/17/2014)... The Alliance for Clinical ... non-profit collaborative building a global system to enhance ... announced Phase 3 of its Site Accreditation and ... H. Kalali, Vice-President, Global Head, Neuroscience Center of ... and Quality Integration (CQI) Consulting will lead the ...
(Date:9/16/2014)... energy from jaw movements has been created by a ... that the device can generate electricity from eating, chewing ... or wearable electronic devices, such as hearing aids, cochlear ... first results of the device,s performance have been published ... Materials and Structures . , Jaw movements have proved ...
Breaking Biology Technology:Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4'Smart material' chin strap harvests energy from chewing 2
... United,Therapeutics Corporation (Nasdaq: UTHR ) announced today ... results before the open of market,on Thursday, May ... half-hour teleconference on Thursday,May 1, 2008, at 9:00 ... 1-800-603-1777, with international callers dialing 1-706-679-8129.,A rebroadcast of ...
... 2008 / b3c newswire / - Sloning BioTechnology ... on a project to synthesize a gene mutant library ... and controlled ratio at preselected positions within a given ... Slonomics™, a unique DNA engineering platform using defined sets ...
... Duke University chemists have found a way to grow ... very large numbers, removing a major roadblock in ... carbon nanotubes also follow parallel paths as they grow ... electronic performance, said Duke associate chemistry professor Jie Liu, ...
Cached Biology Technology:Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library 2Nanotubes grown straight in large numbers 2Nanotubes grown straight in large numbers 3
(Date:9/17/2014)... State,s Institute for the Arts and Humanities has received ... for a two-year project, "The Boundaries of the Human ... project will support a wide-ranging series of events aimed ... humanities. One involves artists and researchers who are exploring ... the idea of humanism, and the other involves the ...
(Date:9/17/2014)... (Sept. 17, 2014) A rare genetic disorder known as ... a recent joint investigation by researchers at San Diego ... In addition to suggesting better treatment options for people ... into the genetic underpinnings of autism., Jacobsen syndrome affects ... Institutes of Health. It occurs in a person when ...
(Date:9/17/2014)... the Copenhagen Centre for Social Evolution and Yale University ... birth weight and -length can partially predict the likelihood ... autism and schizophrenia later in life. The study analyzed ... hospital diagnoses for up to 30 years, and adjusted ... is published today in the Proceedings of the ...
Breaking Biology News(10 mins):Mellon Foundation awards grant for major project in the humanities and sciences 2A link between Jacobsen syndrome and autism 2Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3
... scientists has produced a new type of rice that ... rice crops. Professor Andy Pereira at the Virginia Bioinformatics ... Indonesia, Israel, Italy, Mexico and The Netherlands to identify, ... HARDY that improves key features of this important grain ...
... WI, Sept. 18, 2007 -- Recently, researchers at Iowa ... of a popular crop model. By zeroing in on ... they can help improve yield predictions across a variety ... findings in the September-October issue of Crop Science. ...
... Metagenomics is a revolutionary approach to study microbes. Rather ... is applied directly to environmental samples to obtain information ... a specific habitat studied. The ocean is an ideal ... whose biomass equals that of all other living organisms ...
Cached Biology News:HARDY rice: less water, more food 2HARDY rice: less water, more food 3Simulating kernel production influences maize model accuracy 2Metagenomics of the deep Mediterranean 2
Rabbit polyclonal to GABA A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Rabbit polyclonal to VPAC2 ( Abpromise for all tested applications). entrezGeneID: 7434 SwissProtID: P41587...
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
Biology Products: