Navigation Links
Study offers clues as to why some patients get infections from cardiac implants
Date:10/24/2011

their own surface called fibronectin-binding protein A. To learn more about the bacterial protein, the scientists then sequenced the amino acids that make up fibronectin-binding protein A in each isolate they studied.

And this is where they found the single-nucleotide polymorphisms (or SNPs, pronounced "snips"), which were more common in the isolates collected from patients with infections related to their heart implants.

To further test the effects of these SNPs, the team used a supercomputer to simulate the formation of the bond between the bacterial and human proteins. When they plugged standard amino acid sequences from each protein into the supercomputer, the molecules maintained a distance from each other. When they altered the sequence of three amino acids in the bacterial surface protein and entered that data, hydrogen bonds formed between the bacterial and human proteins.

"We changed the amino acids to resemble the SNPs found in the Staph that came from cardiac device-infected patients," Lower said. "So the SNPs seem to have a relationship to whether a bond forms or not."

Fibronectin-binding protein A is just one of about 10 of these types of molecules on the Staph surface that can form bonds with proteins on host cells, Lower noted. And it's also possible that fibronectin, the human protein on the other side of the bond studied so far, might contain genetic variants that contribute to the problem as well.

What the scientists do know is that bacteria will do all they can to survive, so it won't be easy to outsmart them.

"Bacteria obey Charles Darwin's law of natural selection and can evolve genetic capabilities to allow them to live in the presence of antibiotics," Lower said. "Most physicists would tell you there are certain laws of physics that dictate what happens and when it happens, and you can't evade or evolve ways around those. If you understand the basic physics of it, can you exploit a fundame
'/>"/>

Contact: Steven Lower
lower.9@osu.edu
614-292-1571
Ohio State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology technology :

1. InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
2. RAND study finds increase in piracy and terrorism at sea
3. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist
4. Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure
5. Logical Therapeutics Inc. Announces Results of Phase 1b Clinical Study of its Naproxen Prodrug
6. Video: CSL Behring Provides $1.2M Grant for Worlds First Study of Postpartum Women with VWD, Common Bleeding Disorder
7. RainDance and Scripps to Collaborate on Targeted Sequencing for Wellderly Study
8. Preliminary Report of American Biotech Labs HIV Study Featured in Inaugural Issue of Journal of the Science of Healing Outcomes
9. Pharmasset Reports Preliminary Results of a 4-week Proof-of-Concept Combination Study of R7128 for the Treatment of Chronic Hepatitis C in Genotype 2 or 3 Non-Responders
10. ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications
11. Germicidal UVC Lights Improve Clinical Pregnancy Rates for IVF Lab, New Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study offers clues as to why some patients get infections from cardiac implants
(Date:2/25/2015)... 25, 2015 /CNW/ - Radient Technologies Inc. (TSX-V: RTI) (the ... results for the third quarter of its fiscal year ... Discussion and Analysis, and the CEO & CFO certifications ... 31, 2014 are available on www.SEDAR.com ... The Corporation is also pleased to announce the appointment ...
(Date:2/25/2015)... -- Today, BioMed Realty Trust, Inc. (NYSE: ... promotions and additions to its leadership team focused on ... returns through strategic investments in real estate at the ... innovation sector. The company also announced ... his role as President and Chief Operating Officer to ...
(Date:2/25/2015)... February 25, 2015 Market Publishers Ltd ... drawn up by 9Dimen Research have been recently uploaded ... Industry 2014 Market Research Report . This research report ... performance of the world adhesive mortar industry as well ... across the major regional markets. It focuses on the ...
(Date:2/25/2015)... 25, 2015 AnthroTronix ( http://www.atinc.com ... to optimizing the interaction between people and technology, ... Award Finalist by the internationally renowned Edison Awards™ ... can provide health professionals data within minutes to ... injury and can provide baseline data on brain ...
Breaking Biology Technology:Radient Technologies Inc. Releases Third Quarter Results and Appoints New Interim CFO 2BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 2BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 3BioMed Realty Announces Realignment To Leverage Depth Of Life Science Real Estate Expertise And Increase Shareholder Value 4New Research Studies by 9Dimen Research Now Available at MarketPublishers.com 2New Research Studies by 9Dimen Research Now Available at MarketPublishers.com 3New Research Studies by 9Dimen Research Now Available at MarketPublishers.com 4AnthroTronix Named Edison Awards Finalist for Brain Health Assessment Tool 2AnthroTronix Named Edison Awards Finalist for Brain Health Assessment Tool 3
... is Japan. In this column, I have covered different aspects ... 3/28/05). I had the good fortune to return to Japan ... a three-year hiatus. , ,My last visit there was ... sister city relationship, which had started in Chicago and culminated ...
... Wis. - GE Healthcare , the $15 billion ... U.S. Food and Drug Administration clearance for its heart-imaging ... 70 percent per scan. , ,The technology is based on ... multiple X-ray images together to create a three-dimensional image of ...
... Wis. - Cyber threats are becoming more sophisticated ... companies aren't acting on the threats, a panel of ... on the state of information security during the annual ... technology executives continued to emphasize the necessary balance between ...
Cached Biology Technology:Japan on the rebound: Implications for Midwest 2Japan on the rebound: Implications for Midwest 3Japan on the rebound: Implications for Midwest 4Japan on the rebound: Implications for Midwest 5Japan on the rebound: Implications for Midwest 6Japan on the rebound: Implications for Midwest 7Japan on the rebound: Implications for Midwest 8Japan on the rebound: Implications for Midwest 9FDA approves GE's heart-imaging technology 2Companies still neglect network security 2
(Date:2/5/2015)... Jan. 28, 2015 Research and Markets ... of the "Global Biometrics Market (2014-2020): Market ... Countries " report to their offering. , ... Asia-Pacific is anticipated to overtake ... to increasing government spending towards IT security, government ...
(Date:1/22/2015)... FindBiometrics, the leading source of biometrics industry news, interviews and ... "When we launched FindBiometrics 12 years ago the ... founder and CEO of FindBiometrics. "Now it,s maturing very quickly. ... players on a very broad scale.  We are known for ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... market, reports on the recent success of the Wocket™ smart wallet at ... Wocket smart wallet was named as one of the "11 Hot Products ... Best Products Launched At CES So Far" by Newseveryday.com and "The top ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... is available in German . ... In the wild Arabidopsis thaliana uses the same ... its size in half as found in semi-dwarf varieties of rice and ... various plant species apparently fall back on the same genes in their ...
... abdominal surgery may paradoxically prolong a patient,s suffering, doubling ... to recover from the surgical pain, according to researchers ... team from CU-Boulder,s Department of Psychology and Neuroscienceled by ... Galer, a professional research assistantwas able to identify the ...
... solar panels, wringing every drop of energy from as ... has sent chemistry, materials science and electronic engineering researchers ... photovoltaic devices, but existing techniques are now running up ... Now, researchers from the University of Pennsylvania ...
Cached Biology News:The secret of short stems 2The secret of short stems 3Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find 2Penn and Drexel team demonstrates new paradigm for solar cell construction 2Penn and Drexel team demonstrates new paradigm for solar cell construction 3Penn and Drexel team demonstrates new paradigm for solar cell construction 4Penn and Drexel team demonstrates new paradigm for solar cell construction 5
... is an enhanced form of Tobacco Etch ... highly active, and significantly more stable than ... AcTEV Protease specifically recognizes a seven amino ... making it useful for removing affinity tags ...
... a fully flexible quadrupole MS detector optimized ... HPLC, 1-D and 2-D LC, as well ... incorporates a drying gas system to create ... especially for low-to-medium polarity compounds, while providing ...
S-100A10 (H-80)...
Vapor phase risers are available in various heights to accomodate a variety of inventory solutions. Risers are used to creat a false bottom in which the tanks platform rests and Liquid nitrogen is s...
Biology Products: